{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:28:12Z","timestamp":1792621692163,"version":"4.5.0"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Plast Surg"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n               Background\u2003Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease affecting approximately 1% of young adults. Severe and refractory disease commonly requires surgical excision of the affected skin. To date, there is no consensus regarding the most appropriate reconstructive algorithm.<\/jats:p><jats:p>\n               Materials and Methods\u2003We conducted a retrospective cohort study including all HS patients who underwent surgical excision in the framework of our multidisciplinary clinic. Operative data and postoperative outcome measures were compared between patients who underwent immediate versus delayed reconstruction. Additionally, reconstructive methods were compared and risk factors for adverse postoperative outcome were identified.<\/jats:p><jats:p>\n               Results\u2003A total of 103 patients underwent 158 surgeries for HS excision. The overall complication rate was significantly higher in patients who underwent immediate versus delayed wound closure (31 vs. 16%, p\u2009=\u20090.039). Any intervention for wound closure (immediate or delayed) was associated with increased risk of postoperative complications in comparison to secondary healing (33 vs. 4%, p\u2009&lt;\u20090.001). With delayed closure, the average time to wound closure was 85.4 days with secondary healing only and 57 days with negative pressure wound therapy assisted closure.<\/jats:p><jats:p>\n               Conclusion\u2003Risk factors for adverse postoperative outcome in HS surgery are multifactorial and involve both timing and method of reconstruction in addition to various patient factors. The findings of this study strengthen the notion that delayed closure of post-HS excision wounds leads to the most uneventful course in regard to postoperative adverse events; however, this may take up to 3 months. Upon deciding on a reconstructive plan, the risk-to-benefit ratio should be assessed individually weighing the pros and cons of immediate closure and delayed secondary intention.<\/jats:p>","DOI":"10.1055\/s-0045-1802326","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T23:56:26Z","timestamp":1738367786000},"page":"191-198","source":"Crossref","is-referenced-by-count":2,"title":["Immediate versus Delayed Wound Closure in Hidradenitis Suppurativa Surgery: A Comparative Outcomes Study"],"prefix":"10.1055","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7930-3191","authenticated-orcid":false,"given":"Ehud","family":"Fliss","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Tel Aviv Sourasky Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gon","family":"Shoham","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Tel Aviv Sourasky Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Zoabi","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Tel Aviv Sourasky Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariela","family":"Hafner","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Tel Aviv Sourasky Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Meilik","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Tel Aviv Sourasky Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Manheim","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Tel Aviv Sourasky Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Kedar","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Tel Aviv Sourasky Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoav","family":"Barnea","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Tel Aviv Sourasky Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Gur","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Tel Aviv Sourasky Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Otremski","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Tel Aviv Sourasky Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1056\/NEJMcp1014163","article-title":"Clinical practice. 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Diagnosis, evaluation, and the use of complementary and procedural management","volume":"81","author":"A Alikhan","year":"2019","journal-title":"J Am Acad Dermatol"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.4103\/ijdvl.IJDVL_69_18","article-title":"Hidradenitis suppurativa: a systematic review and meta-analysis of therapeutic interventions","volume":"85","author":"H Tchero","year":"2019","journal-title":"Indian J Dermatol Venereol Leprol"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/jdv.16677","article-title":"Hidradenitis suppurativa: an update on epidemiology, phenotypes, diagnosis, pathogenesis, comorbidities and quality of life","volume":"35","author":"T V Nguyen","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41592-019-0686-2","article-title":"SciPy 1.0: fundamental algorithms for scientific computing in Python","volume":"17","author":"P Virtanen","year":"2020","journal-title":"Nat Methods"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1016\/j.jaad.2015.07.044","article-title":"Recurrence of hidradenitis suppurativa after surgical management: a systematic review and meta-analysis","volume":"73","author":"A Mehdizadeh","year":"2015","journal-title":"J Am Acad Dermatol"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/PRS.0000000000007677","article-title":"Plastic surgical management of hidradenitis suppurativa","volume":"147","author":"E M Taylor","year":"2021","journal-title":"Plast Reconstr Surg"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.bjps.2020.08.026","article-title":"Hidradenitis suppurativa: a review of post-operative outcomes","volume":"74","author":"J Elliott","year":"2021","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"05","key":"ref12","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1097\/PRS.0000000000009024","article-title":"Hidradenitis suppurativa: a comparison of institutional experience and the tracking operations and outcomes for plastic surgeons registry","volume":"149","author":"A W Steele","year":"2022","journal-title":"Plast Reconstr Surg"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.jaad.2020.03.008","article-title":"Surgery is an essential aspect of managing patients with hidradenitis suppurativa","volume":"83","author":"M DM Melendez Gonzalez","year":"2020","journal-title":"J Am Acad Dermatol"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/DSS.0000000000000942","article-title":"Patient satisfaction and quality of life following surgery for hidradenitis suppurativa","volume":"43","author":"J J Kohorst","year":"2017","journal-title":"Dermatol Surg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"219S","DOI":"10.1097\/PRS.0000000000002671","article-title":"What heals hidradenitis suppurativa: surgery, immunosuppression, or both?","volume":"138","author":"R A Falola","year":"2016","journal-title":"Plast Reconstr Surg"},{"issue":"02","key":"ref16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000462979","article-title":"Medical and surgical treatment of hidradenitis suppurativa: a review","volume":"3","author":"N Scuderi","year":"2017","journal-title":"Skin Appendage Disord"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"e4752","DOI":"10.1097\/GOX.0000000000004752","article-title":"Surgical management of hidradenitis suppurativa: factors associated with postoperative complications and disease recurrence","volume":"11","author":"R Skorochod","year":"2023","journal-title":"Plast Reconstr Surg Glob Open"}],"container-title":["Indian Journal of Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0045-1802326.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T23:05:34Z","timestamp":1751411134000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0045-1802326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,31]]},"references-count":17,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2025,7,1]]},"published-print":{"date-parts":[[2025,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0045-1802326","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0970-0358","1998-376X"],"issn-type":[{"value":"0970-0358","type":"print"},{"value":"1998-376X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,31]]}}}