{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:12:46Z","timestamp":1780567966402,"version":"3.54.1"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":58,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Visual atrophy scales from the medial temporal region are auxiliary biomarkers of neurodegeneration in Alzheimer's disease (AD). Therefore, they may correlate with progression from cognitively unimpaired (CU) status to mild cognitive impairment (MCI) and AD, and they become a valuable tool for diagnostic accuracy.<\/jats:p><jats:p>\n          Objective\u2003To compare the medial temporal lobe atrophy (MTA) and entorhinal cortex atrophy (ERICA) scores measured through magnetic resonance image (MRI) scans as a useful method for probable AD diagnosis regarding clinical diagnosis and amyloid positron-emission tomography (PET).<\/jats:p><jats:p>\n          Methods\u2003Two neurologists blinded to the diagnoses classified 113 older adults (age\u2009&gt;\u200965 years) through the MTA and ERICA scores. We investigated the correlations involving these scores and sociodemographic data, amyloid brain cortical burden measured through PET imaging with (11)C-labeled Pittsburgh Compound-B (11C-PIB PET), and clinical cognitive status, in individuals diagnosed as CU (CU; N\u2009=\u200930), presenting mild cognitive impairment (MCI, N\u2009=\u200952), and AD patients (N\u2009=\u200931).<\/jats:p><jats:p>\n          Results\u2003The inter-rater reliability of the atrophy scales was excellent (0.8\u20131) according to the Cohen analysis. The CU group presented lower MTA scores (median value: 0) than ERICA (median value: 1) scores in both hemispheres. The 11C-PIB-PET was positive in 45% of the sample. In the MCI and AD groups, the ERICA score presented greater sensitivity, and the MTA score presented greater specificity. The accuracy of the clinical diagnosis was sufficient and no more than 70% for both scores in AD.<\/jats:p><jats:p>\n          Conclusion\u2003In the present study, we found moderate sensitivity for the ERICA score, which could be a better screening tool than the MTA score for the diagnosis of AD or MCI. However, none of the scores were useful imaging biomarkers in preclinical AD.<\/jats:p>","DOI":"10.1055\/s-0045-1802960","type":"journal-article","created":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:13:33Z","timestamp":1740788013000},"page":"001-007","source":"Crossref","is-referenced-by-count":2,"title":["Diagnosing preclinical and clinical Alzheimer's disease with visual atrophy scales in the clinical practice"],"prefix":"10.1055","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9585-4989","authenticated-orcid":false,"given":"Karen Luiza Ramos","family":"Socher","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Departamento de Neurologia, Grupo de Neurologia Cognitiva e do Comportamento, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2908-9569","authenticated-orcid":false,"given":"Douglas Mendes","family":"Nunes","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Instituto de Radiologia, Unidade de Neurorradiologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0883-2202","authenticated-orcid":false,"given":"Deborah Cristina P.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Departamento de Neurologia, Grupo de Neurologia Cognitiva e do Comportamento, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5555-4583","authenticated-orcid":false,"given":"Artur Martins Novaes","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Hospital das Cl\u00ednicas, Departamento de Radiologia e Oncologia, Laborat\u00f3rio de Medicina Nuclear (LIM\/43), S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1766-2786","authenticated-orcid":false,"given":"Daniele de Paula","family":"Faria","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Hospital das Cl\u00ednicas, Departamento de Radiologia e Oncologia, Laborat\u00f3rio de Medicina Nuclear (LIM\/43), S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5483-759X","authenticated-orcid":false,"given":"Paula","family":"Squarzoni","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Departamento de Psiquiatria, S\u00e3o Paulo SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4749-4602","authenticated-orcid":false,"given":"Geraldo","family":"Busatto Filho","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Departamento de Psiquiatria, S\u00e3o Paulo SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0956-2790","authenticated-orcid":false,"given":"Carlos Alberto","family":"Buchpiguel","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Hospital das Cl\u00ednicas, Departamento de Radiologia e Oncologia, Laborat\u00f3rio de Medicina Nuclear (LIM\/43), S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5721-1525","authenticated-orcid":false,"given":"Ricardo","family":"Nitrini","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Departamento de Neurologia, Grupo de Neurologia Cognitiva e do Comportamento, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8303-6732","authenticated-orcid":false,"given":"Sonia Maria Dozzi","family":"Brucki","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Departamento de Neurologia, Grupo de Neurologia Cognitiva e do Comportamento, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"issue":"03","key":"ref2","doi-asserted-by":"publisher","first-page":"154","DOI":"10.11606\/issn.1679-9836.v94i3p154-161","article-title":"Revis\u00e3o sistem\u00e1tica sobre preval\u00eancia de dem\u00eancia entre a popula\u00e7\u00e3o brasileira","volume":"94","author":"M S Boff","year":"2015","journal-title":"Rev Med (S\u00e3o 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