{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:40:10Z","timestamp":1744418410825,"version":"3.40.4"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":69,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ortop (Sao Paulo)"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Resumo<\/jats:title><jats:p>\n          Objetivo\u2003Analisar, em met\u00e1stases de ossos longos, a incid\u00eancia de complica\u00e7\u00f5es e sobrevida p\u00f3s-operat\u00f3rias at\u00e9 um ano, e correlacion\u00e1-las com a raz\u00e3o neutr\u00f3filo-linf\u00f3cito (RNL) e a raz\u00e3o plaqueta-linf\u00f3cito (RPL).<\/jats:p><jats:p>\n          M\u00e9todos\u2003Revis\u00e3o de 160 prontu\u00e1rios de pacientes submetidos a cirurgias por met\u00e1stases \u00f3sseas no esqueleto apendicular. Al\u00e9m das caracter\u00edsticas epidemiol\u00f3gicas, foram determinados os valores da RNL e da RPL, que foram correlacionados com sobrevida e complica\u00e7\u00f5es.<\/jats:p><jats:p>\n          Resultados\u2003Mulheres representaram 64,5% da amostra, com tumor prim\u00e1rio na mama em 62,6%. O f\u00eamur proximal foi o osso mais acometido. A sobrevida m\u00e9dia foi de 13,2 meses, e a taxa de sobrevida em 1 ano, de 34,7%. Ressec\u00e7\u00e3o tumoral com endopr\u00f3tese foi o procedimento mais comum. A taxa de complica\u00e7\u00e3o p\u00f3s-operat\u00f3ria foi de 10%, e o tempo m\u00e9dio para a ocorr\u00eancia de complica\u00e7\u00f5es p\u00f3s-operat\u00f3rias foi de 27,9 (varia\u00e7\u00e3o: 0\u2013140) dias. Foi identificada uma associa\u00e7\u00e3o da vari\u00e1vel neutr\u00f3filos com as complica\u00e7\u00f5es p\u00f3s-operat\u00f3rias (p\u2009=\u20090,04): a cada 100 unidades a mais de neutr\u00f3filos, houve aumento de 1% nas chances de complica\u00e7\u00f5es p\u00f3s-cir\u00fargicas. Os valores m\u00e9dios da RNL e da RPL foram, respectivamente, de 5,3 (varia\u00e7\u00e3o: 0,2\u201330,7) e de 199,7 (varia\u00e7\u00e3o: 32,1\u2013676,7). Os pacientes com RNL \u2265 2 (p\u2009&lt;\u20090,001) apresentaram diminui\u00e7\u00e3o na sobrevida de 92,3 para 62,5% no terceiro m\u00eas, e de 61,5 para 31,3% em 1 ano. Aqueles com RPL \u2265 209 (p\u2009&lt;\u20090,001) apresentaram diminui\u00e7\u00e3o na sobrevida de 69 para 59,3% no terceiro m\u00eas, e de 40,2 para 25,9% em 1 ano.<\/jats:p><jats:p>\n          Conclus\u00e3o\u2003N\u00e3o houve associa\u00e7\u00e3o positiva entre RNL e RPL com complica\u00e7\u00f5es p\u00f3s-operat\u00f3rias, mas houve uma forte correla\u00e7\u00e3o da RNL e da RPL elevadas com a redu\u00e7\u00e3o da expectativa de vida dos pacientes a partir do terceiro m\u00eas de p\u00f3s-operat\u00f3rio.<\/jats:p>","DOI":"10.1055\/s-0045-1804497","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:25:35Z","timestamp":1744417535000},"page":"001-010","source":"Crossref","is-referenced-by-count":0,"title":["Correla\u00e7\u00e3o das raz\u00f5es neutr\u00f3filo-linf\u00f3cito e plaqueta-linf\u00f3cito com complica\u00e7\u00f5es e sobrevida p\u00f3s-operat\u00f3rias na cirurgia para met\u00e1stase \u00f3ssea do esqueleto 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