{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:11:03Z","timestamp":1791288663504,"version":"4.3.0"},"reference-count":94,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Depressive disorders and suicidal behaviors represent major causes of health loss. Modifications of brain microvasculature, and specifically alterations of the blood\u2013brain barrier have been supposed to participate in the vulnerability to those disorders along with cognitive impairment, especially in the older adults. In this article, we addressed evidence linking blood\u2013brain barrier impairments with mood disorders and suicide. Secondly, we investigated their relationship with depression in old age, and with neurodegenerative processes. Particular attention was drawn toward the potential interactions between the coagulation processes and the blood\u2013brain barrier dysfunctions, as innovative treatment strategies may emerge from research in those fields. Overall, the studies reviewed highlight the implication of multiple dysfunctions of the blood\u2013brain barrier in mood disorders and suicide. Impairments of the blood\u2013brain barrier show relationships with altered expression of endothelial cell junction proteins. These modifications also implicate receptors of the extracellular matrix, the vascular endothelial growth factor, changes in perivascular astrocytes, and has links with local and systemic inflammatory processes. Dysfunctions of the blood\u2013brain barrier underly chronic stress and participate in psychiatric diathesis in old age. In addition, we outline that coagulation processes are likely to interact with the blood\u2013brain barrier and further contribute to neurodegenerative disorders. In conclusion, new pathophysiological models offer perspectives toward detecting new biomarkers in mood disorders and suicide. In parallel, these models open avenues for developing innovative therapeutic agents, although further considering their potential risks and eventual benefits is needed.<\/jats:p>","DOI":"10.1055\/s-0045-1804893","type":"journal-article","created":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T23:30:26Z","timestamp":1741563026000},"page":"457-464","source":"Crossref","is-referenced-by-count":2,"title":["Alterations in the Blood\u2013Brain Barrier in Mood Disorders and Neurodegenerative Diseases"],"prefix":"10.1055","volume":"51","author":[{"given":"Ismael","family":"Conejero","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, CHU N\u00eemes, University of Montpellier, N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Chea","sequence":"additional","affiliation":[{"name":"Department of Hematology, CHU N\u00eemes, N\u00eemes, France"},{"name":"UMR 1318 INSERM-Universit\u00e9 de Montpellier IDESP, France"},{"name":"Faculty of Pharmaceutical and Biological Sciences, University of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Courtet","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics (IGF), University of Montpellier, Montpellier, France"},{"name":"Department of Emergency Psychiatry & Acute Care, CHU Montpellier, University of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Bouvier","sequence":"additional","affiliation":[{"name":"Department of Hematology, CHU N\u00eemes, N\u00eemes, France"},{"name":"UMR 1318 INSERM-Universit\u00e9 de Montpellier IDESP, France"},{"name":"Faculty of Pharmaceutical and Biological Sciences, University of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabricio","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, CHU N\u00eemes, N\u00eemes, France"},{"name":"MIPA, University of N\u00eemes, N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,3,9]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"e729","DOI":"10.1016\/S2468-2667(21)00047-5","article-title":"Prevalence and variability of current depressive disorder in 27 European countries: a population-based study","volume":"6","author":"J Arias-de la Torre","year":"2021","journal-title":"Lancet Public Health"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1001\/jamapsychiatry.2017.4602","article-title":"Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United 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