{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:23:02Z","timestamp":1792520582487,"version":"4.5.0"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":46,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2013\/07559-3"],"award-info":[{"award-number":["2013\/07559-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2021\/11820-5"],"award-info":[{"award-number":["2021\/11820-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003A prior study showed that people with temporal lobe epilepsy (TLE) with an active lifestyle present a better quality of life (QoL), but the influence of aerobic physical exercise (APE) in the QoL of these patients is still unclear. As pharmacoresistance is commonly associated with TLE, the possibility of seizures during the activities might prevent patients from benefiting from APE.<\/jats:p><jats:p>\n          Objective\u2003To analyze the influence of APE in the QoL of TLE patients and also focus on the seizure worry subitem of the QoL in epilepsy 31 (QoLIE-31) questionnaire.<\/jats:p><jats:p>\n          Methods\u2003We analyzed data from 25 individuals with TLE who participated in a 6-month APE program under the supervision of a board-certified physical trainer. TLE patients were divided into training (TLE-training) and control (TLE-control) groups. The TLE-training group underwent an APE program of 6 months, while the control group was oriented to keep their routine. We assessed all patients with the QoLIE-31 at baseline and after 6 months. We used a mixed-between-subjects ANOVA to assess the APE intervention compared with TLE-control pre- and postintervention on the QoL.<\/jats:p><jats:p>\n          Results\u2003We found a significant interaction between intervention groups and APE-time (p\u2009=\u20090.0005), showing that only patients in the TLE-training group presented higher QoL after the intervention (p\u2009=\u20090.001). We found no significant differences between groups for seizure worry (p\u2009=\u20090.50).<\/jats:p><jats:p>\n          Conclusion\u2003There was improvement in QoL due to APE, with no increase in seizure worry, which might be a feature of concern for both patients and healthcare practitioners. Further studies should focus on long-term interventions to evaluate the impact of APE in QoL.<\/jats:p>","DOI":"10.1055\/s-0045-1804919","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T23:58:52Z","timestamp":1742428732000},"page":"001-005","source":"Crossref","is-referenced-by-count":2,"title":["Aerobic physical exercise improves quality of life in temporal lobe epilepsy"],"prefix":"10.1055","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2334-5362","authenticated-orcid":false,"given":"Shai Oisiovici","family":"Laks","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Faculdade de Ci\u00eancias M\u00e9dicas, Campinas SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8991-6952","authenticated-orcid":false,"given":"Nathalia","family":"Volpato","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Faculdade de Ci\u00eancias M\u00e9dicas, Campinas SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3365-3209","authenticated-orcid":false,"given":"Nikolas","family":"Coelho","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Faculdade de Ci\u00eancias M\u00e9dicas, Campinas SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9085-6990","authenticated-orcid":false,"given":"Mateus Henrique","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Faculdade de Ci\u00eancias M\u00e9dicas, Campinas SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3789-8283","authenticated-orcid":false,"given":"Pamela Regina","family":"Henning","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Faculdade de Ci\u00eancias M\u00e9dicas, Campinas SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5016-2487","authenticated-orcid":false,"given":"Aline de Fatima","family":"Dias","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Faculdade de Ci\u00eancias M\u00e9dicas, Campinas SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9241-2928","authenticated-orcid":false,"given":"William Souza Martins","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Faculdade de Ci\u00eancias M\u00e9dicas, Campinas SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9084-7173","authenticated-orcid":false,"given":"Clarissa Lin","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Faculdade de Ci\u00eancias M\u00e9dicas, Campinas SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5045-9512","authenticated-orcid":false,"given":"Luciana Ramalho","family":"Pimentel-Silva","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Faculdade de Ci\u00eancias M\u00e9dicas, Campinas SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9336-9568","authenticated-orcid":false,"given":"Fernando","family":"Cendes","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Faculdade de Ci\u00eancias M\u00e9dicas, Campinas SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"ref1","first-page":"207","volume-title":"The psychopharmacology of epilepsy","author":"M 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