{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:58:32Z","timestamp":1781179112874,"version":"3.54.1"},"reference-count":20,"publisher":"Scientific Scholar","issue":"04","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["South Asian J Cancer"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Transitional cell carcinoma of the urinary bladder is one of the most common malignancies affecting the urinary tract. Genomic instability is one of the most important common features of urothelial cancers of the bladder. Gene polymorphisms of the SLC14A1 gene are known to be related to carcinogenesis of the bladder in humans. Similarly, the use of tobacco products including chewing and smoking is an established risk factor for bladder cancer in both men and women. The primary aim of the study was to assess the relationship between bladder cancer and polymorphisms of the SLC14A1 gene (rs17674580) in our patients with image and histologically confirmed bladder cancer and secondarily to assess if use of tobacco products in these patients further accentuated the risk of bladder cancer.<\/jats:p>\n                  <jats:p>All patients aged \u226518 years with images (ultrasonography\/computed tomography) and histologically confirmed bladder cancer formed the study group. Age- and gender-matched individuals aged \u226518 years, genetically unrelated, formed the controls. A 2-mL blood sample was collected from patients as well as controls, for genotyping of SLC14A1C\/T gene polymorphisms. Demographic data were obtained from all the participants, and individuals who smoked once a day for more than 5 years were defined as smokers. Similarly, patients who chewed tobacco for more than 5 years were defined as tobacco users.<\/jats:p>\n                  <jats:p>During the study period, 107 patients (84 males and 23 females) with image and histologically confirmed bladder cancer formed the study group. The mean age of the patients with bladder cancer was 58.47\u2009\u00b1\u200914.5 years and that of the controls was 60.01\u2009\u00b1\u2009 12.5 years. Among patients with bladder cancer, 28 (26.2%) showed no polymorphisms (rs17674580) of the SLC14A1 gene, whereas 79 (73.8%) patients showed polymorphisms. Heterozygous variations (CT) were noted in 46 (42.9%) patients, whereas homozygous variations were noted in 33 (30.9%) patients with the odds ratio being 2.772 (1.459\u20133.247) and 3.349 (1.610\u20136.922), respectively. The use of tobacco (smoking\/chewing) was also found to modulate risks of bladder cancer in SLC14A1 variants.<\/jats:p>\n                  <jats:p>Gene polymorphisms of SLC14A1C\/T are associated with a high risk of bladder cancer in our group of patients in South India. Moreover, the use of tobacco, be it smoking or chewing, further increases the risk of bladder cancer in these patients.<\/jats:p>","DOI":"10.1055\/s-0045-1805081","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T18:54:11Z","timestamp":1741373651000},"page":"810-814","source":"Crossref","is-referenced-by-count":0,"title":["Association of SLC14A1C\/T Polymorphisms in Patients with Bladder Cancer in Comparison with Healthy Controls"],"prefix":"10.25259","volume":"14","author":[{"given":"Saziya","family":"Bidi","sequence":"additional","affiliation":[{"name":"Urinary Biomarkers Research Centre, KLES Dr. Prabhakar Kore Hospital & Medical Research Centre, Nehru Nagar, Belagavi, Karnataka, India"},{"name":"Department of Urology, JN Medical College, KLE Academy of Higher Education & Research (Deemed-to-be-University), JNMC Campus, Belagavi, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.B","family":"Nerli","sequence":"additional","affiliation":[{"name":"Urinary Biomarkers Research Centre, KLES Dr. Prabhakar Kore Hospital & Medical Research Centre, Nehru Nagar, Belagavi, Karnataka, India"},{"name":"Department of Urology, JN Medical College, KLE Academy of Higher Education & Research (Deemed-to-be-University), JNMC Campus, Belagavi, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadab","family":"Rangrez","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, JGMM Medical College, Hubballi, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shridhar C.","family":"Ghagane","sequence":"additional","affiliation":[{"name":"Urinary Biomarkers Research Centre, KLES Dr. Prabhakar Kore Hospital & Medical Research Centre, Nehru Nagar, Belagavi, Karnataka, India"},{"name":"KAHER's Dr. Prabhakar Kore Basic Science Research Center, KLE Academy of Higher Education & Research, JNMC Campus, Belagavi, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/S0140-6736(16)00561-4","article-title":"Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial","volume":"387","author":"J E Rosenberg","year":"2016","journal-title":"Lancet"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1158\/1078-0432.CCR-18-2039","article-title":"Clonal relatedness and mutational differences between upper tract and bladder urothelial carcinoma","volume":"25","author":"F Audenet","year":"2019","journal-title":"Clin Cancer Res"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s13193-018-0728-8","article-title":"Low-grade, multiple, Ta non-muscle-invasive bladder tumors: tumor recurrence and worsening progression","volume":"9","author":"R B Nerli","year":"2018","journal-title":"Indian J Surg Oncol"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4103\/iju.iju_132_21","article-title":"Detection of bladder cancer using voided urine sample and by targeting genomic VPAC receptors","volume":"37","author":"R B Nerli","year":"2021","journal-title":"Indian J Urol"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/gcc.2870120309","article-title":"Identification of gains and losses of DNA sequences in primary bladder cancer by comparative genomic hybridization","volume":"12","author":"A Kallioniemi","year":"1995","journal-title":"Genes Chromosomes Cancer"},{"issue":"02","key":"ref6","first-page":"363","article-title":"Incidence of bladder cancer at a tertiary care centre in north Karnataka","volume":"13","author":"S I Puranik","year":"2022","journal-title":"Middle East J Cancer"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.mam.2012.12.003","article-title":"The urea transporter family (SLC14): physiological, pathological and structural aspects","volume":"34","author":"C Shayakul","year":"2013","journal-title":"Mol Aspects Med"},{"issue":"21","key":"ref8","doi-asserted-by":"crossref","first-page":"4268","DOI":"10.1093\/hmg\/ddr303","article-title":"European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene","volume":"20","author":"T Rafnar","year":"2011","journal-title":"Hum Mol Genet"},{"issue":"21","key":"ref9","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1093\/hmg\/ddr342","article-title":"A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3","volume":"20","author":"M Garcia-Closas","year":"2011","journal-title":"Hum Mol Genet"},{"issue":"25","key":"ref10","doi-asserted-by":"crossref","first-page":"11775","DOI":"10.7150\/thno.51655","article-title":"SLC14A1 prevents oncometabolite accumulation and recruits HDAC1 to transrepress oncometabolite genes in urothelial carcinoma","volume":"10","author":"T C Chan","year":"2020","journal-title":"Theranostics"},{"key":"ref11","volume-title":"Tobacco Smoke and Involuntary Smoking","author":"IARC","year":"2004"},{"key":"ref12","first-page":"1101","volume-title":"Bladder cancer","author":"D T Silverman","year":"2006","edition":"3rd ed"},{"issue":"02","key":"ref13","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/ijc.23856","article-title":"The effect of smoking on the male excess of bladder cancer: a meta-analysis and geographical analyses","volume":"124","author":"M Hemelt","year":"2009","journal-title":"Int J Cancer"},{"issue":"01","key":"ref14","first-page":"1","article-title":"The relationship between the risk of smoking-related disease, inflammatory response and single-nucleotide polymorphisms","volume":"5","author":"J Biggerstaff","year":"2019","journal-title":"Microreviews Cell Molecular Biology"},{"issue":"02","key":"ref15","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3233\/BLC-170159","article-title":"Bladder cancer genetic susceptibility. A systematic review","volume":"4","author":"E L de Maturana","year":"2018","journal-title":"Bladder Cancer"},{"issue":"03","key":"ref16","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/1097-0142(20000801)89:3<630::AID-CNCR19>3.0.CO;2-Q","article-title":"The impact of characteristics of cigarette smoking on urinary tract cancer risk: a meta-analysis of epidemiologic studies","volume":"89","author":"M P Zeegers","year":"2000","journal-title":"Cancer"},{"issue":"01","key":"ref17","first-page":"485","article-title":"Risk factors for bladder cancer: results of a survey of hospital patients","volume":"9","author":"R Shadab","year":"2023","journal-title":"J Cancer Allied Spec"},{"issue":"03","key":"ref18","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/ije\/dyw044","article-title":"Quantified relations between exposure to tobacco smoking and bladder cancer risk: a meta-analysis of 89 observational studies","volume":"45","author":"F H van Osch","year":"2016","journal-title":"Int J Epidemiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1016\/S0140-6736(16)30512-8","article-title":"Bladder cancer","volume":"388","author":"A M Kamat","year":"2016","journal-title":"Lancet"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"e2244430","DOI":"10.1001\/jamanetworkopen.2022.44430","article-title":"Smoking behaviors and prognosis in patients with non-muscle-invasive bladder cancer in the be-well study","volume":"5","author":"M L Kwan","year":"2022","journal-title":"JAMA Netw Open"}],"container-title":["South Asian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0045-1805081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:13:21Z","timestamp":1781176401000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.sajc.org\/association-of-slc14a1c-t-polymorphisms-in-patients-with-bladder-cancer-in-comparison-with-healthy-controls\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,7]]},"references-count":20,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2025,12,29]]},"published-print":{"date-parts":[[2025,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0045-1805081","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2278-330X","2278-4306"],"issn-type":[{"value":"2278-330X","type":"print"},{"value":"2278-4306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,7]]}}}