{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T21:31:15Z","timestamp":1780695075054,"version":"3.54.1"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Neurosurg"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neurenteric cysts, also known as endodermal or enterogenous cysts, are uncommon benign congenital lesions of the central nervous system (CNS) characterized by an epithelial lining of endodermal origin. These cysts predominantly affect the spinal canal and cord. Intramedullary neurenteric cysts are exceptionally rare, with fewer than 100 reported isolated cases. Their distinct characteristics, clinical presentation, and challenges in diagnosis and treatment necessitate a detailed case analysis and review. We present the case of a 33-year-old male patient with an intriguing case of an isolated intramedullary cystic lesion in the cervicodorsal spinal cord, extending from the cervicobulbar junction to the D4 vertebra level. The patient's clinical presentation included a 6-month history of progressive weakness in the left upper limb, accompanied by pain and numbness. Neurological examination revealed muscle atrophy, reduced strength, spastic paraparesis, and sensory deficits. Radiological findings demonstrated an expansile cystic lesion with marked signal heterogeneity, intense enhancement, and the presence of a \u201ccap sign\u201d indicative of subacute hemorrhage. Diagnosis of spinal intramedullary neurenteric cysts is reliant on histopathology. Surgical removal remains the recommended treatment, as a conservative approach can lead to irreversible neurological deficits. However, complete resection may be challenging due to potential adhesions to surrounding structures. In such cases, a more conservative approach, avoiding cyst spillage into the subarachnoid space, is preferred. Vigilant radiological follow-up is crucial to monitor for potential cyst recurrence. These rare cases highlight the need for further scientific literature and improved diagnostic and therapeutic strategies.<\/jats:p>","DOI":"10.1055\/s-0045-1806727","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T20:29:36Z","timestamp":1742329776000},"page":"408-412","source":"Crossref","is-referenced-by-count":1,"title":["Isolated Intramedullary Spinal Neurenteric Cysts: Case Report and Literature Review"],"prefix":"10.1055","volume":"20","author":[{"given":"Sunil","family":"Buddappa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gauhati Medical College & Hospital, Guwahati, Assam, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh Kumar","family":"Barooah","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gauhati Medical College & Hospital, Guwahati, Assam, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.K.","family":"Baishya","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gauhati Medical College & Hospital, Guwahati, Assam, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazlallah","family":"Afshangian","sequence":"additional","affiliation":[{"name":"Department of Language and Linguistic, Shiraz Branch, Islamic Azad University, Shiraz, Iran"},{"name":"Department of Language, Rodaki Institute of Higher Education, Tonekabone, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6484-6775","authenticated-orcid":false,"given":"Daniel","family":"Encarnacion-Santos","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, People of Friendship Hospital, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9465-2506","authenticated-orcid":false,"given":"Gianluca","family":"Scalia","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, Highly Specialized Hospital and of National Importance \u201dGaribaldi,\u201d Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe E.","family":"Umana","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Trauma Centre, Gamma Knief Centre Cannizaro Hospital, Cannizaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bipin","family":"Chaurasia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Neurosurgery Clinic Birgunj, Birgunj, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1097\/00007632-199211000-00027","article-title":"Spinal neurenteric cyst. Report of two cases and review of forty-one cases reported in Japan","volume":"17","author":"Y Arai","year":"1992","journal-title":"Spine"},{"key":"ref2","first-page":"129","article-title":"Neurenteric cyst of the craniocervical junction. Report of three cases","volume":"94","author":"F L Filho","year":"2001","journal-title":"J Neurosurg"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3171\/jns.1993.78.5.0821","article-title":"Lumbosacral neurenteric cyst in an infant. Case report","volume":"78","author":"M S LeDoux","year":"1993","journal-title":"J Neurosurg"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0303-8467(95)00076-3","article-title":"Craniospinal and spinal enterogenous cysts: report of three cases","volume":"98","author":"M B Rao","year":"1996","journal-title":"Clin Neurol Neurosurg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1001\/archneur.1964.00460190095007","article-title":"Teratomatous cysts of the spinal canal; with \u201csex chromatin\u201d studies","volume":"11","author":"N B Rewcastle","year":"1964","journal-title":"Arch Neurol"},{"issue":"09","key":"ref6","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/BF01411408","article-title":"Intramedullary neurenteric cyst without any associated malformation. One case evaluated by RMI and electron microscopic study","volume":"139","author":"M Rivi\u00e9rez","year":"1997","journal-title":"Acta Neurochir (Wien)"},{"key":"ref7","first-page":"305","article-title":"Intramedullary neurenteric cysts of the spine. Case report and review of the literature","volume":"94","author":"C R Lippman","year":"2001","journal-title":"J Neurosurg"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3171\/2014.11.SPINE14352","article-title":"Clinical presentation and surgical outcomes of intramedullary neurenteric cysts","volume":"23","author":"T Yang","year":"2015","journal-title":"J Neurosurg Spine"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4103\/2152-7806.98525","article-title":"Intramedullary neurenteric cyst associated with a tethered spinal cord: case report and literature review","volume":"3","author":"J A Vachhani","year":"2012","journal-title":"Surg Neurol Int"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4103\/0974-8237.65484","article-title":"Neurenteric cysts of the spine","volume":"1","author":"J J Savage","year":"2010","journal-title":"J Craniovertebr Junction Spine"},{"issue":"05","key":"ref11","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3171\/2012.1.PEDS11469","article-title":"Intramedullary spinal neurenteric cyst with fluid-fluid level","volume":"9","author":"S S Jhawar","year":"2012","journal-title":"J Neurosurg Pediatr"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"592.e9","DOI":"10.1016\/j.wneu.2015.03.015","article-title":"Spinal neurenteric cyst in association with Klippel-Feil syndrome: case report and literature review","volume":"84","author":"A Can","year":"2015","journal-title":"World Neurosurg"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4103\/0974-8237.85314","article-title":"Intramedullary enterogenous cyst of the conus medullaris presenting as lower limb pain","volume":"2","author":"S Balasubramaniam","year":"2011","journal-title":"J Craniovertebr Junction Spine"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.wneu.2018.07.027","article-title":"Giant craniospinal intramedullary neurenteric cyst in infant-case report and review of literature","volume":"118","author":"B Diyora","year":"2018","journal-title":"World Neurosurg"},{"issue":"06","key":"ref15","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1016\/j.spinee.2013.10.051","article-title":"Spinal intramedullary arachnoid cyst: case report and literature review","volume":"14","author":"F Novegno","year":"2014","journal-title":"Spine J"},{"issue":"02","key":"ref16","doi-asserted-by":"crossref","first-page":"290","DOI":"10.4103\/1793-5482.145557","article-title":"A rare case of solid calcified intramedullary neurenteric cyst: case report and technical note","volume":"12","author":"K C Joshi","year":"2017","journal-title":"Asian J Neurosurg"},{"issue":"03","key":"ref17","first-page":"302","article-title":"Intramedullary neurenteric cyst in mid thoracic spine in an adult: a case report","volume":"49","author":"B S Singhal","year":"2001","journal-title":"Neurol India"},{"issue":"04","key":"ref18","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1136\/jnnp.71.4.528","article-title":"Intramedullary enterogenous cyst presenting with spastic paraparesis during two consecutive pregnancies: a case report","volume":"71","author":"J W Reinders","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"02","key":"ref19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000065111","article-title":"Intramedullary neurenteric cyst presenting as infantile paraplegia: a case and review","volume":"37","author":"D Agrawal","year":"2002","journal-title":"Pediatr Neurosurg"},{"key":"ref20","first-page":"512","article-title":"Neurenteric cysts in children: 16 consecutive cases and review of the literature","volume":"103","author":"R S de Oliveira","year":"2005","journal-title":"J Neurosurg"},{"issue":"03","key":"ref21","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3171\/spi.2005.2.3.0372","article-title":"Intramedullary neurenteric cysts of the spine. 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