{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:48:13Z","timestamp":1774975693104,"version":"3.50.1"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Plast Surg"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Secondary lymphedema negatively impacts the quality of life. Lympho-venous anastomosis (LVA) has shown to attenuate lymphedema symptoms.<\/jats:p>\n                  <jats:p>The aim of the study is to evaluate the efficacy, patient satisfaction, and quality of life following LVA for breast cancer\u2013related lymphedema (BCRL) in the Indian setup.<\/jats:p>\n                  <jats:p>We conducted a prospective, nonrandomized, feasibility study at a single institute. Sixteen patients with BCRL undergoing secondary LVA between May 2020 and December 2021 were included in the study. Volumetry was done preoperatively and then 6, 12, and 18 months postoperatively. The Indian limb lymphedema scoring (ILLS) system questionnaire and satisfaction scoring were done 1 year postoperatively.<\/jats:p>\n                  <jats:p>Sixteen patients undergoing secondary LVA for BCRL were included in the study. The preoperative mean difference in limb circumference volume was 804.41\u2009\u00b1\u2009472.01. This was reduced to 471.81\u2009\u00b1\u2009292.216\u2009mL at the 6-month follow-up (t\u2009=\u2009\u20136.6323; p \u2264 0.00001), 448.58\u2009\u00b1\u2009255.93 (t\u2009=\u2009\u20135.5295; p\u2009=\u20090.00006) at 12 months, and 445.25\u2009\u00b1\u2009345.78 (t\u2009=\u2009\u20136.8957; p \u2264 0.00001) at 18 months of follow-up. The mean volume difference between the two limbs at 12 months post-LVA was 515.3144\u2009\u00b1\u2009284.2007\u2009mL (t\u2009=\u20091.9972; p\u2009=\u20090.1250) and 362.7957\u2009\u00b1\u2009201.9709\u2009mL (t\u2009=\u20090.1221; p\u2009=\u20090.4522). The number of LVAs did not show a statistically significant difference in outcome with a volume difference of 515.3144\u2009\u00b1\u2009284.2007 and 362.7957\u2009\u00b1\u2009201.9709\u2009mL in groups with less than four and more than four anastomosis and a p-value of 0.1250 and 0.4522, respectively. Similarly, body mass index (BMI) and duration of lymphedema did not show a statistically significant difference in outcome (p\u2009=\u20090.2648 and 0.2281, respectively). The mean total ILLS were 31.35 and 13.66 pre- and postoperatively, respectively, showing a statistically significant improvement in the quality of life, with a p-value of 0.00023.<\/jats:p>\n                  <jats:p>LVA significantly improves the quality of life and reduces limb volume, with stabilization occurring at 18 months, and the number of anastomoses, patient's BMI, and lymphedema duration did not affect volume reduction in our set of patients.<\/jats:p>","DOI":"10.1055\/s-0045-1806746","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T20:26:17Z","timestamp":1742329577000},"page":"343-350","source":"Crossref","is-referenced-by-count":2,"title":["Quality of Life Post Lympho-Venous Anastomosis in Breast Cancer\u2013Related Lymphedema in the Indian Population"],"prefix":"10.1055","volume":"58","author":[{"given":"Annika","family":"Marwah","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Manipal hospital, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8866-9910","authenticated-orcid":false,"given":"Ashok Basur","family":"Chandrappa","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Manipal hospital, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srikanth","family":"Vasudevan","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Manipal hospital, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ananteshwar","family":"Y.N","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Manipal hospital, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Jana","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Manipal hospital, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeet","family":"Radadia","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Manipal Hospital, Bangalore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pooja","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Manipal hospital, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"B.","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Manipal hospital, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"issue":"09","key":"ref1","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1001\/jamasurg.2019.1742","article-title":"Factors associated with lymphedema in women with node-positive breast cancer treated with neoadjuvant chemotherapy and axillary dissection","volume":"154","author":"J M Armer","year":"2019","journal-title":"JAMA Surg"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ejso.2012.10.011","article-title":"Complications of lymphadenectomy for gynecologic cancer","volume":"39","author":"A Achouri","year":"2013","journal-title":"Eur J Surg Oncol"},{"issue":"08","key":"ref3","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1097\/IGC.0000000000000226","article-title":"Swelling among women who need education about leg lymphedema: a descriptive study of lymphedema in women undergoing surgery for endometrial cancer","volume":"24","author":"R Salani","year":"2014","journal-title":"Int J Gynecol Cancer"},{"issue":"11","key":"ref4","first-page":"3063","article-title":"Lower limb lymphedema in gynecological cancer survivors: effect on daily life functioning","volume":"21","author":"G Dunberger","year":"2013","journal-title":"Support Care Cancer"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/iwj.12648","article-title":"The impact of lower limb chronic oedema on patients' quality of life","volume":"14","author":"A Greene","year":"2017","journal-title":"Int Wound J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ejogrb.2015.06.011","article-title":"Impact of lower limb lymphedema on quality of life in gynecologic cancer survivors after pelvic lymph node dissection","volume":"192","author":"S I Kim","year":"2015","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10354-013-0202-8","article-title":"M\u00f6glichkeiten der chirurgischen therapie des lymph\u00f6dems [Possibilities of surgical therapy of lymphedema]","volume":"163","author":"W D\u00f6ller","year":"2013","journal-title":"Wien Med Wochenschr"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF02096466","article-title":"Microsurgical anatomy in China","volume":"11","author":"S Z Zhong","year":"1989","journal-title":"Surg Radiol Anat"},{"issue":"04","key":"ref9","first-page":"312","article-title":"The treatment of lymphedema of the extremities with microsurgical lympho-venous anastomoses","volume":"7","author":"W L Olszewski","year":"1988","journal-title":"Int Angiol"},{"issue":"01","key":"ref10","first-page":"72","article-title":"Indocyanine green lymphography findings in limb lymphedema","volume":"32","author":"M Narushima","year":"2016","journal-title":"J Reconstr Microsurg"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/micr.20214","article-title":"Lymphatic microsurgery for the treatment of lymphedema","volume":"26","author":"C Campisi","year":"2006","journal-title":"Microsurgery"},{"issue":"13","key":"ref12","first-page":"653","article-title":"Diagnostiek en behandeling van lymfoedeem[Diagnosis and treatment of lymphedema]","volume":"139","author":"L H van Cruchten","year":"1995","journal-title":"Ned Tijdschr Geneeskd"},{"issue":"02","key":"ref13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10549-008-9932-5","article-title":"Lymphatic venous anastomosis (LVA) for treatment of secondary arm lymphedema. A prospective study of 11 LVA procedures in 10 patients with breast cancer related lymphedema and a critical review of the literature","volume":"113","author":"R J Damstra","year":"2009","journal-title":"Breast Cancer Res Treat"},{"issue":"08","key":"ref14","doi-asserted-by":"crossref","first-page":"651","DOI":"10.2340\/16501977-0232","article-title":"Impact of lymphoedema on arm function and health-related quality of life in women following breast cancer surgery","volume":"40","author":"D J Dawes","year":"2008","journal-title":"J Rehabil Med"}],"container-title":["Indian Journal of Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0045-1806746.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T23:30:31Z","timestamp":1761953431000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0045-1806746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,18]]},"references-count":14,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2025,10,31]]},"published-print":{"date-parts":[[2025,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0045-1806746","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0970-0358","1998-376X"],"issn-type":[{"value":"0970-0358","type":"print"},{"value":"1998-376X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,18]]}}}