{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:46:41Z","timestamp":1767649601727,"version":"3.41.0"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Multiple sclerosis (MS) affects mainly young people of reproductive age with significant lifelong repercussions, among which sexual dysfunction (SD) is one of the most neglected during routine clinical care.<\/jats:p><jats:p>\n          Objective\u2003To evaluate SD in female patients diagnosed with relapsing-remitting MS (RRMS).<\/jats:p><jats:p>\n          Methods\u2003This cross-sectional analytic study was performed at the Santa Casa de S\u00e3o Paulo Hospital, Faculdade de Ci\u00eancias M\u00e9dicas, S\u00e3o Paulo, Brazil, between November 2020 and March 2022. The sample included 80 female patients diagnosed with RRMS and 106 healthy controls. Questionnaires probing sexual dysfunction (the Multiple Sclerosis Intimacy and Sexuality Questionnaire \u2013 MSISQ-19 and the Female Sexual Function Index \u2013 FSFI) and depression and anxiety (the Hospital Anxiety and Depression Scale \u2013 HADS, the Beck Depression Inventory \u2013 BDI; and the Beck Anxiety Inventory \u2013 BAI) were applied.<\/jats:p><jats:p>\n          Results\u2003A high prevalence of SD in both groups (43.4% and 38.8% for the RRMS and control groups, respectively) was identified by the FSFI analysis. A statistically higher prevalence (56.3%) of sexual dysfunction was detected in RRMS patients when using the MSISQ-19 tool to assess sexuality in this population compared with the FSFI scale (p\u2009=\u20090.016).<\/jats:p><jats:p>\n          Conclusion\u2003A high prevalence of SD was found in both MS patients and healthy controls as measured by the FSFI. However, the specific tool (MSISQ-19) revealed a higher prevalence of SD in MS patients. Thus, the use of MSISQ-19 for the diagnosis and management of SD in this patient group is recommended.<\/jats:p>","DOI":"10.1055\/s-0045-1806819","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:32:39Z","timestamp":1745368359000},"page":"001-008","source":"Crossref","is-referenced-by-count":1,"title":["Assessing female sexual dysfunction in patients with relapsing-remitting multiple sclerosis"],"prefix":"10.1055","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6448-8277","authenticated-orcid":false,"given":"Elisa Matias Vieira de","family":"Melo","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo, Faculdade de Ci\u00eancias M\u00e9dicas, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8381-0532","authenticated-orcid":false,"given":"Flavia Fairbanks Lima de Oliveira","family":"Ruano","sequence":"additional","affiliation":[{"name":"University of Miami, Department of Obstetrics Gynecology and Reproductive Sciences, Female Sexual Health Program, Coral Gables FL, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3983-6019","authenticated-orcid":false,"given":"Maria Fernanda","family":"Mendes","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo, Faculdade de Ci\u00eancias M\u00e9dicas, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2717-7522","authenticated-orcid":false,"given":"Guilherme Sciascia do","family":"Olival","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo, Faculdade de Ci\u00eancias M\u00e9dicas, S\u00e3o Paulo SP, 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