{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:38:43Z","timestamp":1793140723851,"version":"4.5.0"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":49,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Levodopa-induced dyskinesia (LID) remains a significant motor complication in Parkinson's disease (PD), although opinions differ on its clinical relevance.<\/jats:p>\n                  <jats:p>To explore the current prevalence and impact of LID, we analyzed two cohorts from the Latin American Research Consortium on the Genetics of Parkinson's Disease from movement disorder clinics in the city of S\u00e3o Paulo, Brazil, recruited 10 years apart.<\/jats:p>\n                  <jats:p>The cohorts included 187 individuals diagnosed with PD in phase 1 (2007\u20132014) and 224 in phase 2 (2021\u20132022). The presence and functional impact of LID were measured using part IV (items 4.1 and 4.2 respectively) of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS).<\/jats:p>\n                  <jats:p>The analysis revealed that LID frequency increased from 34.7 in phase 1 to 54.9% in phase 2 (more recent), with functional impact rising from 25.1 to 38.8%.<\/jats:p>\n                  <jats:p>The findings suggest that LID remains a relevant clinical issue in clinics specialized in movement disorders in Brazil, with no reduction in prevalence throughout the last decade. Further studies from other regions and less specialized neurology centers may help understand this motor complication in Brazil and in other developing countries.<\/jats:p>","DOI":"10.1055\/s-0045-1806922","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T20:17:55Z","timestamp":1747772275000},"page":"001-005","source":"Crossref","is-referenced-by-count":10,"title":["Levodopa-induced dyskinesia is still a major clinical problem in Brazilian movement disorder clinics"],"prefix":"10.1055","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2402-2709","authenticated-orcid":false,"given":"Vitor","family":"Tumas","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina de Ribeir\u00e3o Preto, Departamento de Neuroci\u00eancias e Ci\u00eancias do Comportamento, Ribeir\u00e3o Preto SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2915-6637","authenticated-orcid":false,"given":"Manuelina Mariana Capellari Macruz","family":"Brito","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina de Ribeir\u00e3o Preto, Departamento de Neuroci\u00eancias e Ci\u00eancias do Comportamento, Ribeir\u00e3o Preto SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8723-2757","authenticated-orcid":false,"given":"Vanderci","family":"Borges","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Departamento de Neurologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3821-1407","authenticated-orcid":false,"given":"Henrique Ballalai","family":"Ferraz","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Departamento de Neurologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7739-4306","authenticated-orcid":false,"given":"Cyrus P.","family":"Zabetian","sequence":"additional","affiliation":[{"name":"Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, WA, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1198-0633","authenticated-orcid":false,"given":"Ignacio F.","family":"Mata","sequence":"additional","affiliation":[{"name":"Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland OH, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9321-5710","authenticated-orcid":false,"given":"Bruno Lopes","family":"Santos-Lobato","sequence":"additional","affiliation":[{"name":"Universidade Federal do Par\u00e1, Faculdade de Medicina, Laborat\u00f3rio de Neuropatologia Experimental, Bel\u00e9m PA, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1002\/ana.25364","article-title":"Levodopa-induced dyskinesia in Parkinson disease: Current and evolving concepts","volume":"84","author":"A J Espay","year":"2018","journal-title":"Ann Neurol"},{"issue":"04","key":"ref2","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1001\/archneur.1969.00480160015001","article-title":"Treatment of parkinsonism with levodopa","volume":"21","author":"M D Yahr","year":"1969","journal-title":"Arch Neurol"},{"issue":"01","key":"ref3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0733-8619(18)30372-4","article-title":"Pharmacokinetic and pharmacodynamic considerations in management of motor response fluctuations in Parkinson's disease","volume":"8","author":"J M Cedarbaum","year":"1990","journal-title":"Neurol Clin"},{"issue":"06","key":"ref4","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1002\/mds.27691","article-title":"Should there be less emphasis on levodopa-induced dyskinesia in Parkinson's disease?","volume":"34","author":"K R Chaudhuri","year":"2019","journal-title":"Mov Disord"},{"issue":"24","key":"ref5","doi-asserted-by":"publisher","first-page":"e2238","DOI":"10.1212\/WNL.0000000000006643","article-title":"Levodopa-induced dyskinesia in Parkinson disease: A population-based cohort study","volume":"91","author":"P Turcano","year":"2018","journal-title":"Neurology"},{"issue":"03","key":"ref6","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1002\/mds.27959","article-title":"Dyskinesia matters","volume":"35","author":"M A Cenci","year":"2020","journal-title":"Mov Disord"},{"issue":"04","key":"ref7","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1002\/mds.29335","article-title":"Cross-Cultural Differences in Patient Perceptions of Dyskinesia in Parkinson's Disease","volume":"38","author":"V Kaasinen","year":"2023","journal-title":"Mov Disord"},{"issue":"12","key":"ref8","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1002\/mds.27891","article-title":"Parkinson's disease-associated dyskinesia in countries with low access to levodopa-sparing regimens","volume":"34","author":"S P Reddy","year":"2019","journal-title":"Mov Disord"},{"issue":"07","key":"ref9","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1002\/mdc3.14056","article-title":"Levodopa-Induced Dyskinesias are Frequent and Impact Quality of Life in Parkinson's Disease: A 5-Year Follow-Up Study","volume":"11","author":"D Santos-Garc\u00eda","year":"2024","journal-title":"Mov Disord Clin Pract"},{"issue":"16","key":"ref10","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.1002\/mds.22341","article-title":"The Unified Dyskinesia Rating Scale: presentation and clinimetric profile","volume":"23","author":"C G Goetz","year":"2008","journal-title":"Mov Disord"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0045-1806922.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:30:17Z","timestamp":1761521417000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0045-1806922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":10,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2025,3,19]]},"published-print":{"date-parts":[[2025,4]]}},"alternative-id":["s00451806922"],"URL":"https:\/\/doi.org\/10.1055\/s-0045-1806922","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0004-282X","1678-4227"],"issn-type":[{"value":"0004-282X","type":"print"},{"value":"1678-4227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]}}}