{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:40:38Z","timestamp":1770813638131,"version":"3.50.1"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dental caries is an infectious disease that develops through biofilm. Streptococcus mutans is a cariogenic bacterium that can be found in dental plaque. Streptococcus mutans regulates biofilm formation and communicate with other microbes through a process called quorum sensing. Dental caries prevention can be achieved by inhibiting quorum sensing. This study aimed to investigate the ability of Lactobacillus plantarum and Candida albicans to inhibit the formation of S. mutans polymicrobial biofilms.<\/jats:p>\n                  <jats:p>This study aims to investigate the ability of biofilm formation analyzed through the crystal violet (CV) assay and bacterial metabolic activity analyzed through the methylthiazol tetrazolium (MTT) assay. The bacteria used are S. mutans (serotype C), L. plantarum (FNCC 0020), and C. albicans.<\/jats:p>\n                  <jats:p>CV assay results show that in the presence of L. plantarum, biofilm formation in S. mutans decreases (9.5%). Meanwhile, the formation of S. mutans biofilms increased with the presence of C. albicans (28.8%). MTT assay results showed an increase in the metabolic activity of S. mutans in the presence of L. plantarum (20.2%) and C. albicans (19.4%).<\/jats:p>\n                  <jats:p>Lactobacillus plantarum can inhibit the formation of S. mutans biofilms, while C. albicans can increase S. mutans biofilms.<\/jats:p>","DOI":"10.1055\/s-0045-1806962","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T18:52:04Z","timestamp":1746211924000},"page":"183-187","source":"Crossref","is-referenced-by-count":0,"title":["Formation of Streptococcus mutans Polymicrobial Biofilms in the Presence of Lactobacillus plantarum and Candida albicans"],"prefix":"10.1055","volume":"20","author":[{"given":"Indah Listiana","family":"Kriswandini","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Khoswanto","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Luthfi","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinta Rahayuning","family":"Tyas","sequence":"additional","affiliation":[{"name":"Student of Dental Medicine Education Study Program, Faculty of Dental Medicine, Universitas Airlangga Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelheid Chrissanda","family":"Hermanto","sequence":"additional","affiliation":[{"name":"Student of Dental Medicine Education Study Program, Faculty of Dental Medicine, Universitas Airlangga Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6311-2534","authenticated-orcid":false,"given":"Mohammed Ahmed","family":"Aljunaid","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Faculty of Medicine, Taiz University, Taiz Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1007\/s42770-021-00624-x","article-title":"Microbial biofilm: formation, architecture, antibiotic resistance, and control strategies","volume":"52","author":"M A Rather","year":"2021","journal-title":"Braz J Microbiol"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femspd\/ftac010","article-title":"Polymicrobial interaction in biofilm: mechanistic insights","volume":"80","author":"A 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