{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:24:59Z","timestamp":1793147099992,"version":"4.5.0"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nucl Med"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This article aims to assess the presence of skeletal and soft tissue infections before or after treatment and to assess treatment response in Ga-68 citrate positron emission tomography\/computed tomography (PET\/CT) scan positive patients.<\/jats:p>\n                  <jats:p>A prospective study was conducted for 43 patients. The eligibility criteria included those patients clinically suspected of infections who underwent a Ga-68 citrate PET\/CT. Exclusion criteria were pregnancy and lactation. Patients with suspicion of infection or treatment failure underwent a Ga-68 citrate PET\/CT between January 2020 and November 2021. Among these, eight patients underwent a follow-up scan posttreatment to assess their treatment response. The Institutional Review Board (IRB No.12511) approved the study.<\/jats:p>\n                  <jats:p>Forty-three patients underwent a diagnostic Ga-68 citrate PET\/CT scan. The scan interpretation was based on visual comparison of uptake of Ga-68 citrate in the region of interest, which was compared with the normal side\/adjacent soft tissue\/blood pool. The semiquantitative parameter maximum standardized uptake value was retrospectively analyzed as well. PET\/CT findings were correlated with tissue diagnosis, clinical symptoms, biochemical parameters like C-reactive protein (CRP), erythrocyte sedimentation rate, and total leukocyte count, and other imaging modalities with a statistically significant association with CRP (p\u2009=\u20090.001). Tissue diagnosis was considered the gold standard and out of the 43 patients included in the study, 27 had a tissue diagnosis. Sensitivity, specificity, negative predictive value, positive predictive value, and accuracy were calculated at 100, 87.5, 100, 95, and 96.3%, respectively.<\/jats:p>\n                  <jats:p>Ga-68 citrate is a promising tool to assess the presence of bone and soft tissue infections before or after treatment.<\/jats:p>","DOI":"10.1055\/s-0045-1807256","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T19:47:13Z","timestamp":1743536833000},"page":"305-318","source":"Crossref","is-referenced-by-count":6,"title":["Gallium-68 Citrate PET\/CT for Diagnosis and Treatment Response Assessment of Infections\u2014Prospective Study"],"prefix":"10.1055","volume":"24","author":[{"given":"Hanna Elizabeth","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Christian Medical College and Hospital, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saumya Sara","family":"Sunny","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Christian Medical College and Hospital, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Christian Medical College and Hospital, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regi","family":"Oommen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Christian Medical College and Hospital, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nylla","family":"Shanthly","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Christian Medical College and Hospital, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Rupali","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Christian Medical College and Hospital, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regi","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India"},{"name":"Department of ENT-1, Head & Neck Skull Base Surgery Unit, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Sundaresan","sequence":"additional","affiliation":[{"name":"Department of ENT-1, Head & Neck Skull Base Surgery Unit, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumant","family":"Samuel","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Christian Medical College and Hospital, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Oommen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Christian Medical College and Hospital, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesh","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Spinal Disorder Surgery, Christian Medical College and Hospital, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9917-3926","authenticated-orcid":false,"given":"Julie","family":"Hephzibah","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Christian Medical College 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