{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T23:12:50Z","timestamp":1788649970569,"version":"build-2803163510"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Reprod Med"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Radical trachelectomy has become an accepted fertility-sparing treatment for patients with early-stage cervical cancer. Despite its oncological safety, radical trachelectomy is associated with persistent sexual dysfunction and voiding issues, complicating long-term quality of life. Fertility outcomes demonstrate overall pregnancy rates ranging from 25.7-73%, with less radical procedures such as conization and simple trachelectomy reporting higher pregnancy rates compared with radical trachelectomy. Assisted reproductive treatments might be necessary due to complications such as cervical stenosis. During pregnancy, there is an elevated risk of miscarriage, preterm delivery, and premature rupture of membranes due to cervical shortening. However, less radical fertility-sparing procedures such as conization and simple trachelectomy demonstrate lower preterm delivery rates. Prophylactic cerclage, as well as close monitoring of cervical length during pregnancy, is essential, and cesarean section remains the recommended method of delivery. Recent studies suggest that less radical fertility-sparing procedures may provide comparable oncological safety while reducing complications, highlighting the need to reevaluate surgical approaches. This review provides an overview of reproductive and obstetrical outcomes in patients after treatment for early-stage cervical cancer with trachelectomy. This review additionally emphasizes the need for further research to refine fertility-sparing strategies.<\/jats:p>","DOI":"10.1055\/s-0045-1808092","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T19:21:16Z","timestamp":1744917676000},"page":"011-015","source":"Crossref","is-referenced-by-count":3,"title":["After Radical Trachelectomy: Reproductive and Obstetrical Outcomes of Fertility-Sparing Surgery for Cervical Cancer"],"prefix":"10.1055","volume":"43","author":[{"given":"Sinor","family":"Soltanizadeh","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel","family":"Rosendahl","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligita Paskeviciute","family":"Fr\u00f8ding","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe Frahm","family":"Bj\u00f8rn","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit Jul","family":"Mosgaard","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"H\u00f8gdall","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1002\/ijc.35081","article-title":"Cervical cancer incidence in Denmark: disentangling determinants of time trend","volume":"155","author":"E Lynge","year":"2024","journal-title":"Int J Cancer"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1016\/S2214-109X(19)30482-6","article-title":"Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis","volume":"8","author":"M Arbyn","year":"2020","journal-title":"Lancet Glob Health"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/S1470-2045(24)00523-0","article-title":"The current and future global burden of cancer among adolescents and young adults: a population-based study","volume":"25","author":"T Hughes","year":"2024","journal-title":"Lancet Oncol"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1136\/ijgc-2023-004429","article-title":"ESGO\/ESTRO\/ESP Guidelines for the management of patients with cervical cancer - update 2023","volume":"33","author":"D Cibula","year":"2023","journal-title":"Int J Gynecol Cancer"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1007\/s11912-022-01317-w","article-title":"Fertility-sparing and less radical surgery for cervical cancer","volume":"24","author":"S H Batman","year":"2022","journal-title":"Curr Oncol Rep"},{"issue":"08","key":"ref6","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/(SICI)1097-0142(20000415)88:8<1877::AID-CNCR17>3.0.CO;2-W","article-title":"Laparoscopic vaginal radical trachelectomy: a treatment to preserve the fertility of cervical carcinoma patients","volume":"88","author":"D Dargent","year":"2000","journal-title":"Cancer"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s11701-024-01982-y","article-title":"Surgical procedures and techniques in robot-assisted uterine artery-preserving radical trachelectomy","volume":"18","author":"S Han","year":"2024","journal-title":"J Robot Surg"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ygyno.2015.05.016","article-title":"Vaginal radical trachelectomy for early stage cervical cancer. results of the Danish National Single Center Strategy","volume":"138","author":"L Hauerberg","year":"2015","journal-title":"Gynecol Oncol"},{"issue":"13","key":"ref9","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.ejca.2015.05.012","article-title":"Incidence, risk factors and treatment of cervical stenosis after radical trachelectomy: a systematic review","volume":"51","author":"X Li","year":"2015","journal-title":"Eur J Cancer"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.ygyno.2021.12.029","article-title":"Long term oncologic and reproductive outcomes after robot-assisted radical trachelectomy for early-stage cervical cancer. 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