{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:04:25Z","timestamp":1754161465378,"version":"3.41.2"},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Medication-overuse headache (MOH) was first described in 1951 with ergotamine overuse. Since then, much has been studied about its risk factors, pathophysiology, prevention, and treatment. Despite this, many people still suffer from this condition. Even for those who reach medical care, the path to maintaining significant improvement is neither short nor easy. Here, we propose the ubiquitous individualization of headache treatment. The more we study the condition, the more it becomes evident that different groups of patients benefit from different approaches: starting prophylactic medication immediately or postponing it, providing a bridge treatment or not, and advising patients to either stop medication overuse immediately or reduce it gradually.<\/jats:p>","DOI":"10.1055\/s-0045-1809333","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T22:49:03Z","timestamp":1753742943000},"page":"001-002","source":"Crossref","is-referenced-by-count":0,"title":["In the era of monoclonal antibodies targeting the calcitonin gene-related peptide pathway, is it still necessary to stop taking excessive pain medication?"],"prefix":"10.1055","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9780-4739","authenticated-orcid":false,"given":"Renata Gomes","family":"Londero","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre, Servi\u00e7o de Neurologia, Cl\u00ednica de Cefaleia, Porto Alegre RS, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"issue":"09","key":"ref1","first-page":"153","article-title":"Headache: with special reference to the excessive use of ergotamine preparations and withdrawal effects","volume":"26","author":"G A Peters","year":"1951","journal-title":"Proc Staff Meet Mayo Clin"},{"issue":"14","key":"ref2","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1212\/WNL.0000000000200252","article-title":"Patient-Centered Treatment of Chronic Migraine With Medication Overuse: More Is Not Always Better","volume":"98","author":"A I Scher","year":"2022","journal-title":"Neurology"},{"issue":"04","key":"ref3","doi-asserted-by":"publisher","first-page":"3331024231156922","DOI":"10.1177\/03331024231156922","article-title":"Randomized controlled studies evaluating Topiramate, Botulinum toxin type A, and mABs targeting CGRP in patients with chronic migraine and medication overuse headache: A systematic review and meta-analysis","volume":"43","author":"S Giri","year":"2023","journal-title":"Cephalalgia"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/s12883-014-0181-4","article-title":"Dependency-like behaviors and pain coping styles in subjects with chronic migraine and medication overuse: results from a 1-year follow-up study","volume":"14","author":"B Biagianti","year":"2014","journal-title":"BMC Neurol"},{"issue":"01","key":"ref5","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1468-2982.2004.00789.x","article-title":"Medication overuse headache: rates and predictors for relapse in a 4-year prospective study","volume":"25","author":"Z Katsarava","year":"2005","journal-title":"Cephalalgia"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"104943","DOI":"10.1016\/j.ebiom.2023.104943","article-title":"Resistant and refractory migraine: clinical presentation, pathophysiology, and management","volume":"99","author":"R Ornello","year":"2024","journal-title":"EBioMedicine"},{"issue":"03","key":"ref7","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/j.1468-2982.2009.01913.x","article-title":"Patterns of medication use by chronic and episodic headache sufferers in the general population: results from the frequent headache epidemiology study","volume":"30","author":"A I Scher","year":"2010","journal-title":"Cephalalgia"},{"issue":"09","key":"ref8","doi-asserted-by":"publisher","first-page":"4451","DOI":"10.1007\/s10072-024-07496-7","article-title":"The transition of medication overuse status by acute medication categories in episodic or chronic migraine patients to non-overuse status after receiving anti-CGRP monoclonal antibodies: a systematic review and meta-analysis of phase 3 randomized control trial","volume":"45","author":"C Sirilertmekasakul","year":"2024","journal-title":"Neurol Sci"},{"issue":"05","key":"ref9","doi-asserted-by":"publisher","first-page":"e367","DOI":"10.1016\/S2589-7500(24)00047-5","article-title":"Randomised controlled trials evaluating artificial intelligence in clinical practice: a scoping review","volume":"6","author":"R Han","year":"2024","journal-title":"Lancet Digit Health"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0045-1809333.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T22:49:04Z","timestamp":1753742944000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0045-1809333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":9,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2025,6,21]]},"published-print":{"date-parts":[[2025,9]]}},"alternative-id":["s00451809333"],"URL":"https:\/\/doi.org\/10.1055\/s-0045-1809333","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0004-282X","1678-4227"],"issn-type":[{"type":"print","value":"0004-282X"},{"type":"electronic","value":"1678-4227"}],"subject":[],"published":{"date-parts":[[2025,7,28]]}}}