{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:08:27Z","timestamp":1792004907131,"version":"4.4.0"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":50,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple sclerosis (MS) is the main cause of nontraumatic neurological disabilities in the population under 50 years of age.<\/jats:p><jats:p>To evaluate the most prevalent symptoms in a national sample of people with MS and to analyze their correlation with disease characteristics, demographics, quality of life, employment status, and use of social benefits.<\/jats:p><jats:p>Cross-sectional, online, self-reported survey, concerning demographic and clinical data, employment status, and use of social benefits.<\/jats:p><jats:p>A total of 466 patients answered the survey. The median age at onset was 30 years, the current age, of 39, and disease duration was 8 years. Furthermore, the median patient determined disease steps (PDDS) was 2, which indicates minor to moderate disability. The median MS impact and walking scale scores were 31 and 20%, which denotes minor to moderate quality of life and mobility compromise. Among the participants, 43% suffered fatigue and 51% reported not sleeping well. Unemployed patients had delayed diagnosis and higher disability rates. Furthermore, half of the unemployed patients are receiving some social benefit, compared with only 6.5% of the employed patients.<\/jats:p><jats:p>The current study presents symptom prevalence in a national sample of patients with MS and discloses that those with a diagnosis delay and more disability have higher rates of unemployment and use of social benefits. Strategies for earlier diagnosis and better treatment plans can not only reduce patient disability but, possibly, increase employment retention and reduce the use of social benefits.<\/jats:p>","DOI":"10.1055\/s-0045-1809400","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T22:58:51Z","timestamp":1750460331000},"page":"001-008","source":"Crossref","is-referenced-by-count":2,"title":["The impact of multiple sclerosis on wellbeing, productivity, and societal relations"],"prefix":"10.1055","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5149-2306","authenticated-orcid":false,"given":"Vinicius Eduardo","family":"Vergani","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3418-7603","authenticated-orcid":false,"given":"Bruna Rocha","family":"Silveira","sequence":"additional","affiliation":[{"name":"Amigos M\u00faltiplos pela Esclerose, Guarulhos SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6926-3392","authenticated-orcid":false,"given":"Gustavo San Martin Elexpe","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Amigos M\u00faltiplos pela Esclerose, Guarulhos SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2129-8251","authenticated-orcid":false,"given":"Jean","family":"Faber","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Disciplina de Neuroci\u00eancias, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4011-3734","authenticated-orcid":false,"given":"Denis Bernardi","family":"Bichuetti","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Disciplina de Neurologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"ref1","first-page":"37","article-title":"Esclerose M\u00faltipla","volume":"71","author":"G Bienes","year":"2014","journal-title":"Rev Bras Med"},{"issue":"S 01","key":"ref2","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1016\/j.msard.2016.07.003","article-title":"Brain health: time matters in multiple sclerosis","volume":"9","author":"G Giovannoni","year":"2016","journal-title":"Mult Scler Relat Disord"},{"issue":"10","key":"ref3","doi-asserted-by":"publisher","first-page":"936","DOI":"10.3109\/09638288.2015.1070295","article-title":"Work-related problems in multiple sclerosis: a literature review on its associates and determinants","volume":"38","author":"A Raggi","year":"2016","journal-title":"Disabil Rehabil"},{"issue":"17","key":"ref5","doi-asserted-by":"publisher","first-page":"e1641","DOI":"10.1212\/WNL.0000000000012726","article-title":"Effect of Changes in MS Diagnostic Criteria Over 25 Years on Time to Treatment and Prognosis in Patients With Clinically Isolated Syndrome","volume":"97","author":"M Tintore","year":"2021","journal-title":"Neurology"},{"issue":"08","key":"ref6","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1177\/1352458517694432","article-title":"New insights into the burden and costs of multiple sclerosis in Europe","volume":"23","author":"G Kobelt","year":"2017","journal-title":"Mult Scler"},{"issue":"01","key":"ref7","doi-asserted-by":"publisher","first-page":"e0208837","DOI":"10.1371\/journal.pone.0208837","article-title":"Burden and cost of multiple sclerosis in Brazil","volume":"14","author":"G Kobelt","year":"2019","journal-title":"PLoS One"},{"issue":"05","key":"ref8","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1474-4422(18)30499-X","article-title":"Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"GBD 2016 Neurology Collaborators","year":"2019","journal-title":"Lancet Neurol"},{"issue":"05","key":"ref9","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1590\/0004-282X20190051","article-title":"Employment status of people diagnosed with multiple sclerosis in Brazil","volume":"77","author":"C M Estrutti","year":"2019","journal-title":"Arq Neuro-Psiquiatr"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s12913-016-1352-3","article-title":"Cost analysis of multiple sclerosis in Brazil: a cross-sectional multicenter study","volume":"16","author":"NLd Silva","year":"2016","journal-title":"BMC Health Serv Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.msard.2019.02.022","article-title":"Validation of the Brazilian version of the patient-determined disease steps scale in persons with multiple sclerosis","volume":"30","author":"ACd David","year":"2019","journal-title":"Mult Scler Relat Disord"},{"issue":"03","key":"ref12","doi-asserted-by":"publisher","first-page":"433","DOI":"10.34024\/rnc.2011.v19.8349","article-title":"Adapta\u00e7\u00e3o Transcultural e Valida\u00e7\u00e3o da Escala de Impacto de Esclerose M\u00faltipla","volume":"19","author":"J Lopes","year":"2001","journal-title":"Rev Neurocienc"},{"issue":"12","key":"ref13","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1590\/s0004-282x2012001200004","article-title":"Cross-cultural adaptation and validation of the 12-item Multiple Sclerosis Walking Scale (MSWS-12) for the Brazilian population","volume":"70","author":"B E Marangoni","year":"2012","journal-title":"Arq Neuro-Psiquiatr"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"A339","DOI":"10.1016\/j.jval.2011.08.532","article-title":"PND66 Cross-cultural adaptation and validation version of the Fatigue Severity Scale (FSS)","volume":"14","author":"F O Toledo","year":"2011","journal-title":"Value Health"},{"key":"ref16","volume-title":"Adapta\u00e7\u00e3o e Valida\u00e7\u00e3o do \u00cdndice de Gravidade de Ins\u00e2nia (IGI): Caracteriza\u00e7\u00e3o Populacional, Valores Normativos e Aspectos Associados","author":"LdS Castro","year":"2011"},{"issue":"06","key":"ref18","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.msard.2015.08.004","article-title":"Prevalence of multiple sclerosis in Brazil: A systematic review","volume":"4","author":"ABdG Pereira","year":"2015","journal-title":"Mult Scler Relat Disord"},{"issue":"01","key":"ref20","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.dhjo.2017.04.008","article-title":"People with multiple sclerosis report significantly worse symptoms and health related quality of life than the US general population as measured by PROMIS and NeuroQoL outcome measures","volume":"11","author":"D Amtmann","year":"2018","journal-title":"Disabil Health J"},{"issue":"08","key":"ref21","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1136\/jnnp.2006.090365","article-title":"Costs and quality of life of patients with multiple sclerosis in Europe","volume":"77","author":"G Kobelt","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"13","key":"ref22","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1177\/1352458519877810","article-title":"The long-term outcomes of CIS patients in the Barcelona inception cohort: Looking back to recognize aggressive MS","volume":"26","author":"M Tintore","year":"2020","journal-title":"Mult Scler"},{"issue":"02","key":"ref23","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1177\/1352458517751049","article-title":"ECTRIMS\/EAN Guideline on the pharmacological treatment of people with multiple sclerosis","volume":"24","author":"X Montalban","year":"2018","journal-title":"Mult Scler"},{"issue":"17","key":"ref24","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1212\/WNL.0000000000005347","article-title":"Practice guideline recommendations summary: Disease-modifying therapies for adults with multiple sclerosis: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology","volume":"90","author":"A Rae-Grant","year":"2018","journal-title":"Neurology"},{"issue":"08","key":"ref25","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1590\/0004-282X20180078","article-title":"Brazilian Consensus for the Treatment of Multiple Sclerosis: Brazilian Academy of Neurology and Brazilian Committee on Treatment and Research in Multiple Sclerosis","volume":"76","author":"V D Marques","year":"2018","journal-title":"Arq Neuro-Psiquiatr"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0045-1809400.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T22:58:53Z","timestamp":1750460333000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0045-1809400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":21,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2025,5,9]]},"published-print":{"date-parts":[[2025,5]]}},"alternative-id":["s00451809400"],"URL":"https:\/\/doi.org\/10.1055\/s-0045-1809400","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0004-282X","1678-4227"],"issn-type":[{"value":"0004-282X","type":"print"},{"value":"1678-4227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]}}}