{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:14:55Z","timestamp":1777853695289,"version":"3.51.4"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":47,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spinal cord injury (SCI) results in changes in autonomic function, impacting an individual's movement, sensory perception, and overall quality of life. Phyllanthin, a lignan from Phyllanthus amarus, is known for its neuronal protective effects.<\/jats:p><jats:p>To evaluate the potential of phyllanthin identified in P. amarus methanolic extract (PAME) against SCI in experimental rats.<\/jats:p><jats:p>The lignan was identified in PAME using high-performance liquid chromatography (HPLC). Spinal cord injury was induced in Sprague-Dawley rats using the laminectomy clip compression method. Rats received either a vehicle (distilled water) or methylprednisolone (30\u2009mg\/kg) or PAME (50, 100, and 200\u2009mg\/kg) orally for 4 weeks after SCI. Behavioral, histological, and molecular parameters were assessed to evaluate the neuroprotective effects of phyllanthin.<\/jats:p><jats:p>During the HPLC analysis of PAME, phyllanthin was present at a retention time of 25.30\u2009minutes with 75.22% weight per weight (w\/w). The administration of standardized PAME (100 and 200\u2009mg\/kg) effectively ameliorated the alterations induced by SCI in thermal and mechano-tactile hyperalgesia, locomotor activity, and nerve conduction velocity (p\u2009&lt;\u20090.05 each). The SCI-induced elevation in spinal interleukins (ILs: IL-1\u03b2 and IL-6) and tumor necrosis factor alpha (TNF-\u03b1) protein levels was also effectively (p\u2009&lt;\u20090.05) reduced by PAME. The PAME treatment markedly (p\u2009&lt;\u20090.05) ameliorated SCI-induced alterations in protein expressions of B-cell leukemia\/lymphoma 2 (Bcl-2), Bcl2-associated X protein (Bax), and caspase-3 in the spinal cord. Aberrations, such as inflammatory infiltration, edema, congestion, and necrosis induced in the spinal cord, were also effectively reduced by the PAME treatment (p\u2009&lt;\u20090.05).<\/jats:p><jats:p>Phyllanthin identified in P. amarus showed neuroprotective potential against SCI by moderating impairments in behavioral (allodynia, hyperalgesia, and nerve conduction velocity) parameters, elevated inflammatory mediators (IL-1\u03b2, IL-6, and TNF-\u03b1), and deactivating the apoptotic signaling (Bax\/caspase-3) pathway.<\/jats:p>","DOI":"10.1055\/s-0045-1809408","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T23:38:29Z","timestamp":1750203509000},"page":"001-009","source":"Crossref","is-referenced-by-count":1,"title":["Phyllanthin from Phyllanthus amarus exerts neuroprotective effects against spinal cord injury in experimental rats"],"prefix":"10.1055","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9490-7993","authenticated-orcid":false,"given":"Juan","family":"He","sequence":"additional","affiliation":[{"name":"Sichuan University, West China Hospital, West China School of Nursing, Department of Neurosurgery, Chengdu Sichuan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3204-1786","authenticated-orcid":false,"given":"Yang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Sichuan University, West China Hospital, West China School of Nursing, Department of Neurosurgery, Chengdu Sichuan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3146-496X","authenticated-orcid":false,"given":"Yuekun","family":"Yang","sequence":"additional","affiliation":[{"name":"Sichuan University, West China Hospital, West China School of Nursing, Department of Neurosurgery, Chengdu Sichuan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4428-4902","authenticated-orcid":false,"given":"Zhaofeng","family":"Fan","sequence":"additional","affiliation":[{"name":"Sichuan University, West China Hospital, West China School of Nursing, Department of Neurosurgery, Chengdu Sichuan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1007\/s11999-016-5133-4","article-title":"Classifications In Brief: American Spinal Injury Association (ASIA) Impairment Scale","volume":"475","author":"T T Roberts","year":"2017","journal-title":"Clin Orthop Relat Res"},{"issue":"06","key":"ref2","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1177\/21925682211031190","article-title":"Direct Cost of Illness for Spinal Cord Injury: A Systematic 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