{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:52:36Z","timestamp":1783597956499,"version":"3.55.0"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"07","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High-intensity focused ultrasound (HIFU) has emerged as a minimally invasive and incision-free alternative for managing tremors associated with essential tremor (ET) and Parkinson's disease (PD). Approved by the United States Food and Drug Administration (FDA) for unilateral and staged bilateral thalamotomy, HIFU also addresses cardinal PD symptoms such as rigidity and bradykinesia through pallidotomy. Tremor improvement rates range from 50 to 75% for ET and 60 to 90% for tremor-dominant PD, with long-term efficacy sustained up to 5 years posttreatment, including 73% tremor improvement in a recent controlled multicenter study. Unlike deep brain stimulation (DBS), HIFU eliminates hardware-related complications, such as infections and intracerebral hemorrhage, and minimizes postprocedural maintenance. Adverse events are primarily mild and transient, including temporary paresthesia and imbalance. Real-time magnetic resonance imaging (MRI) guidance enhances targeting precision, enabling patients to resume daily activities within 24\u2009hours. These attributes make HIFU a durable and effective treatment option.<\/jats:p>","DOI":"10.1055\/s-0045-1809660","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:11:46Z","timestamp":1752797506000},"page":"001-004","source":"Crossref","is-referenced-by-count":1,"title":["High-intensity focused ultrasound (HIFU) versus deep brain stimulation (DBS) for refractory tremor: team HIFU"],"prefix":"10.1055","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5306-6908","authenticated-orcid":false,"given":"Karina Silveira","family":"Massruh\u00e1","sequence":"additional","affiliation":[{"name":"Universidade de Sa\u0303o Paulo, Faculdade de Medicina, Departamento de Neurologia, Centro de Distu\u0301rbios do Movimento, Sa\u0303o Paulo SP, Brazil."},{"name":"Hospital Israelita Albert Einstein, Departamento de Neurologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5542-4527","authenticated-orcid":false,"given":"Ellison Fernando","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, Departamento de Imagem, S\u00e3o Paulo SP, Brazil."},{"name":"Universidade de Sa\u0303o Paulo, Faculdade de Medicina, Hospital das Cl\u00ednicas, Instituto de Radiologia, Se\u00e7\u00e3o de Neurorradiologia, Sa\u0303o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"issue":"07","key":"ref1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJMoa1300962","article-title":"A pilot study of focused ultrasound thalamotomy for essential tremor","volume":"369","author":"W J Elias","year":"2013","journal-title":"N Engl J 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