{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T01:22:11Z","timestamp":1773969731056,"version":"3.50.1"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Radiol Imaging"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To investigate the added role of apparent diffusion coefficient (ADC) in differentiating benign from malignant pathologies.<\/jats:p>\n                  <jats:p>Hospital-based random sampling was done and all the females with clinical details suggestive of endometrial pathologies and abnormal ultrasound underwent contrast-enhanced magnetic resonance imaging (MRI). In addition to the routine sequences, imaging was done at different b-values and ADC was calculated. The higher the ADC value the more the chances of benignity. Dynamic contrast-enhanced imaging was also done. Two radiologists with 18 and 10 years of experience evaluated the imaging findings and interobserver agreement was also made. Imaging findings were correlated with diagnosis as made by endometrial aspirate biopsy, dilatation\u2013curettage, or postoperative histopathological examination.<\/jats:p>\n                  <jats:p>The addition of ADC value and dynamic contrast-enhanced MRI showed a significant role in differentiating benign from malignant conditions. The mean ADC measurement in malignant lesions was 0.88\u2009\u00d7\u200910\u22123\u2009\u00b1\u20090.27\u2009\u00d7\u200910\u22123, whereas the mean ADC measurement for benign lesions was 1.03\u2009\u00d7\u200910\u22123\u2009\u00b1\u20090.38\u2009\u00d7\u200910\u22123. The differences between the two were found to be significant (t-value: 2.754, p-value: 0.014). The cutoff of mean ADC and minimum ADC with the highest sensitivity and specificity were reported to be \u22641\u2009\u00d7\u200910\u22123 and \u22640.8\u2009\u00d7\u200910\u22123, respectively.<\/jats:p>\n                  <jats:p>Adding the ADC value with routine magnetic resonance sequences plays a significant role in differentiating between benign and malignant endometrial pathologies, especially in indeterminate cases<\/jats:p>","DOI":"10.1055\/s-0045-1809903","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T19:11:07Z","timestamp":1750792267000},"page":"239-246","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Apparent Diffusion Coefficient in Differentiating Benign and Malignant Endometrial Pathologies: A Prospective Single-Center Study"],"prefix":"10.1055","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6816-5018","authenticated-orcid":false,"given":"Poonam","family":"Sherwani","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences Rishikesh, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8627-2992","authenticated-orcid":false,"given":"Khanak","family":"Nandolia","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, All India Institute of Medical Sciences Rajkot, Rajkot, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-2105","authenticated-orcid":false,"given":"Latika","family":"Chawla","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences Rishikesh, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3614-6074","authenticated-orcid":false,"given":"Arvind","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences Rishikesh, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9064-2047","authenticated-orcid":false,"given":"Anjum","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, All India Institute of Medical Sciences Rishikesh, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7095-8965","authenticated-orcid":false,"given":"Ranjeeta","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, All India Institute of Medical Sciences Rishikesh, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"issue":"01","key":"ref1","first-page":"73","article-title":"Diffusion-weighted imaging in the benign-malignant differentiation of endometrial pathologies; effectiveness of visual evaluation","volume":"33","author":"I Basaran","year":"2023","journal-title":"J Coll Physicians Surg Pak"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1148\/rg.220070","article-title":"Update on MRI in evaluation and treatment of endometrial cancer","volume":"42","author":"E Maheshwari","year":"2022","journal-title":"Radiographics"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/jmri.20997","article-title":"Diffusion-weighted MR imaging of uterine endometrial cancer","volume":"26","author":"K Tamai","year":"2007","journal-title":"J Magn Reson Imaging"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.2214\/AJR.06.1403","article-title":"Diffusion-weighted MRI in the body: applications and challenges in oncology","volume":"188","author":"D M Koh","year":"2007","journal-title":"AJR Am J Roentgenol"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.ejrad.2013.11.030","article-title":"Utility of conventional and diffusion-weighted MRI features in distinguishing benign from malignant endometrial lesions","volume":"83","author":"A S Kierans","year":"2014","journal-title":"Eur J Radiol"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00330-007-0787-7","article-title":"The utility of diffusion-weighted MR imaging for differentiating uterine sarcomas from benign leiomyomas","volume":"18","author":"K Tamai","year":"2008","journal-title":"Eur Radiol"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/jmri.24534","article-title":"Correlation of apparent diffusion coefficient value with prognostic parameters of endometrioid carcinoma","volume":"41","author":"C Inoue","year":"2015","journal-title":"J Magn Reson Imaging"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/RCT.0b013e3181d0f666","article-title":"The value of the apparent diffusion coefficient in differentiating stage IA endometrial carcinoma from normal endometrium and benign diseases of the endometrium: initial study at 3-T magnetic resonance scanner","volume":"34","author":"J Wang","year":"2010","journal-title":"J Comput Assist Tomogr"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3390\/cancers14020384","article-title":"Staging of endometrial cancer using fusion T2-weighted images with diffusion-weighted images: a way to avoid gadolinium?","volume":"14","author":"T R Neves","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"05","key":"ref10","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1148\/rg.345130131","article-title":"Diffusion-weighted imaging of gynecologic tumors: diagnostic pearls and potential pitfalls","volume":"34","author":"S Dhanda","year":"2014","journal-title":"Radiographics"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/GRF.0b013e318196153c","article-title":"Imaging of endometrial pathology","volume":"52","author":"B F Lane","year":"2009","journal-title":"Clin Obstet Gynecol"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ejrnm.2017.02.008","article-title":"Efficiency of diffusion weighted magnetic resonance in differentiation between benign and malignant endometrial lesions","volume":"48","author":"A Elsammak","year":"2017","journal-title":"Egypt J Radiol Nucl Med"},{"issue":"1007","key":"ref13","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1259\/bjr\/14980811","article-title":"Diffusion-weighted imaging in the assessment of tumour grade in endometrial cancer","volume":"84","author":"N Bharwani","year":"2011","journal-title":"Br J Radiol"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2214\/AJR.07.2155","article-title":"Diffusion-weighted single-shot echo-planar imaging with parallel technique in assessment of endometrial cancer","volume":"190","author":"S H Shen","year":"2008","journal-title":"AJR Am J Roentgenol"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s40644-020-00346-7","article-title":"High resolution diffusion-weighted imaging with readout segmentation of long variable echo-trains for determining myometrial invasion in endometrial carcinoma","volume":"20","author":"M Xie","year":"2020","journal-title":"Cancer Imaging"}],"container-title":["Indian Journal of Radiology and Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0045-1809903.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T23:42:57Z","timestamp":1773963777000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0045-1809903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":15,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2026,3,19]]},"published-print":{"date-parts":[[2026,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0045-1809903","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0971-3026","1998-3808"],"issn-type":[{"value":"0971-3026","type":"print"},{"value":"1998-3808","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,24]]}}}