{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:37:29Z","timestamp":1773326249651,"version":"3.50.1"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":69,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Herpes Zoster Oticus is etiologically associated with the reactivation of the Varicella-Zoster virus in the geniculate ganglion. Its primary manifestation includes pain, vesicles in the external auditory canal, and peripheral facial paralysis. The prognosis of the syndrome remains under scrutiny and debate, fluctuating based on symptom severity and clinical manifestation. The scarcity of articles accurately correlating clinical presentation and prognosis, coupled with individual factors and the syndrome's rarity, constrains more comprehensive analyses.<\/jats:p>\n                  <jats:p>To conduct a systematic review to determine whether it is possible to predict the prognosis of RHS based on clinical factors.<\/jats:p>\n                  <jats:p>This study identified a total of 6,464 articles within the databases, which were subsequently evaluated by two independent researchers. Sixty-two articles underwent full-text examinations, and following meticulous selection criteria, twelve articles were ultimately incorporated into this study. Factors such as age, onset of House-Brackmann degree, dizziness, hearing loss, time to treatment initiation, and comorbidities appear to exert influence on prognosis. The articles exhibit methodological limitations and discrepancies among them, stemming from variations in prognostic concepts, treatment protocols, evaluation timing, or reported outcomes. These variations hinder the possibility of conducting a methodologically sound comparison, regardless of how closely aligned the trials are with the theme.<\/jats:p>\n                  <jats:p>The review concludes that it is not possible to definitively assert the presence of a clinical parameter defining the prognosis in Herpes Zoster Oticus.<\/jats:p>","DOI":"10.1055\/s-0045-1810000","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:47:57Z","timestamp":1773276477000},"page":"001-009","source":"Crossref","is-referenced-by-count":0,"title":["Herpes Zoster Oticus: Systematic Review of Clinical Prognostic Factors"],"prefix":"10.1055","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9430-3074","authenticated-orcid":false,"given":"Arthur Justi","family":"Cassettari","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7335-4489","authenticated-orcid":false,"given":"Vagner Ant\u00f4nio Rodrigues","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3133-4356","authenticated-orcid":false,"given":"Agr\u00edcio Nubiato","family":"Crespo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"issue":"7465","key":"ref1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1136\/bmj.329.7465.553","article-title":"Recent developments in Bell's palsy","volume":"329","author":"N J Holland","year":"2004","journal-title":"BMJ"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/00016488109133259","article-title":"Electroneurography in the prognostication of Bell's palsy","volume":"92","author":"L Thomander","year":"1981","journal-title":"Acta Otolaryngol"},{"issue":"01","key":"ref3","first-page":"1","article-title":"Acute Bell's palsy: prognostic value of evoked electromyography, maximal stimulation, and other electrical tests","volume":"5","author":"M May","year":"1983","journal-title":"Am J Otol"},{"issue":"06","key":"ref4","first-page":"494","article-title":"Prognostic value of electrical tests in acute facial paralysis","volume":"5","author":"U Fisch","year":"1984","journal-title":"Am J Otol"},{"issue":"16","key":"ref5","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1056\/NEJMoa072006","article-title":"Early treatment with prednisolone or acyclovir in Bell's palsy","volume":"357","author":"F M Sullivan","year":"2007","journal-title":"N Engl J Med"},{"issue":"07","key":"ref6","doi-asserted-by":"crossref","first-page":"E283","DOI":"10.1002\/lary.24542","article-title":"Etiology, diagnosis, and management of facial palsy: 2000 patients at a facial nerve center","volume":"124","author":"M H Hohman","year":"2014","journal-title":"Laryngoscope"},{"issue":"549","key":"ref7","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1080\/000164802760370736","article-title":"Bell's palsy: the spontaneous course of 2,500 peripheral facial nerve palsies of different etiologies","author":"E Peitersen","year":"2002","journal-title":"Acta Otolaryngol Suppl"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1365-2273.1988.tb01134.x","article-title":"The natural history of facial paralysis in herpes zoster","volume":"13","author":"P P Devriese","year":"1988","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1177\/01945998860953P105","article-title":"Ramsay Hunt facial paralysis: clinical analyses of 185 patients","volume":"95","author":"R B Robillard","year":"1986","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00005053-190702000-00001","article-title":"On herpetic inflammations of the geniculate ganglion. 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