{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:58:42Z","timestamp":1760151522690,"version":"build-2065373602"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Idiopathic normal-pressure hydrocephalus shows a typical clinical triad consisting of gait disturbance, dementia, and urinary incontinence, often combined with ventriculomegaly. Fortunately, these clinical manifestations are potentially reversible by adequate surgical treatment. Men affected by Klinefelter's syndrome can present cognitive problems. These include impairments in both verbal and nonverbal memory and in executive functions, which could be related to idiopathic normal-pressure hydrocephalus in these patients. In this study, we describe the case of a 62-year-old-man genetically diagnosed with Klinefelter's syndrome with a history of gait ataxia resulting in recurrent falls. Direct associations between idiopathic normal-pressure hydrocephalus and Klinefelter's syndrome and clinical pathophysiologic and potential molecular implications are discussed.<\/jats:p>","DOI":"10.1055\/s-0045-1810046","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T22:54:36Z","timestamp":1754434476000},"page":"591-595","source":"Crossref","is-referenced-by-count":0,"title":["Chromosomal Abnormalities and Hydrocephalus: Could There Be an Association between Klinefelter's Syndrome and Idiopathic Normal-Pressure Hydrocephalus?"],"prefix":"10.1055","volume":"86","author":[{"given":"Alessandro","family":"Pesce","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, Univerisity of Rome, Tor Vergata, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graziano","family":"Taddei","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Santa Maria Goretti Hospital, Latina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Palmieri","sequence":"additional","affiliation":[{"name":"Human Neurosciences Department, Neurosurgery Division, University Sapienza of Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Ciarlo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Santa Maria Goretti Hospital, Latina, Italy"},{"name":"School of Neurosurgery, University of Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Carnevale","sequence":"additional","affiliation":[{"name":"Nursing School, University Sapienza of Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Elia","sequence":"additional","affiliation":[{"name":"Nursing School, University Sapienza of Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Pompucci","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Santa Maria Goretti Hospital, Latina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianpaolo","family":"Petrella","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Santa Maria Goretti Hospital, Latina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJM196507152730301","article-title":"Symptomatic occult hydrocephalus with \u201cnormal\u201d cerebrospinal-fluid pressure. 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