{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:02:23Z","timestamp":1792789343745,"version":"4.5.0"},"reference-count":79,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Reprod Med"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Borderline ovarian tumors (BOTs) are commonly diagnosed in women of reproductive age, raising concerns about the impact of surgical management on fertility. This review explores the role of fertility-sparing surgery (FSS) and fertility preservation (FP) strategies in young women diagnosed with BOTs. While FSS carries a slightly higher risk of recurrence compared to bilateral salpingo-oophorectomy, there is growing evidence supporting the safety of FSS, with no adverse effects on 10-year overall survival. In light of this, recent multidisciplinary guidelines recommend FSS for BOT at all stages. A significant proportion of women with BOTs report infertility prior to diagnosis, suggesting a possible pathophysiological link between reduced reproductive fitness and the development of BOT. The potential association between ovarian stimulation (OS) and an increased risk of BOT remains controversial, with current evidence failing to establish a definitive causal link. For women with recurrent stage I BOT and no evidence of peritoneal disease on imaging, OS followed by oocyte retrieval is a viable option before definitive surgery. Notably, a history of BOT does not significantly affect pregnancy outcomes following IVF. FP counseling is essential to tailor treatment plans that address both oncological and reproductive needs in patients undergoing FSS for BOT.<\/jats:p>","DOI":"10.1055\/s-0045-1810420","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:12:14Z","timestamp":1753315934000},"page":"023-031","source":"Crossref","is-referenced-by-count":3,"title":["Fertility Following Fertility-Sparing Surgery for Borderline Ovarian Tumors"],"prefix":"10.1055","volume":"43","author":[{"given":"Stefan","family":"Cosyns","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Oncology, Universitair Ziekenhuis Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5019-5924","authenticated-orcid":false,"given":"Michel","family":"De Vos","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium"},{"name":"Research Group Follicle Biology, Vrije Universiteit Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/ijc.23724","article-title":"Borderline ovarian tumors in Sweden 1960-2005: trends in incidence and age at diagnosis compared to ovarian cancer","volume":"123","author":"I Sk\u00edrnisd\u00f3ttir","year":"2008","journal-title":"Int J Cancer"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.bpobgyn.2011.12.006","article-title":"Borderline ovarian tumours","volume":"26","author":"C G Trop\u00e9","year":"2012","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"08","key":"ref4","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.humpath.2004.03.003","article-title":"Borderline ovarian tumors: key points and workshop summary","volume":"35","author":"S GBD Silverberg","year":"2004","journal-title":"Hum Pathol"},{"issue":"S 02","key":"ref5","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/S0893-3952(22)04457-X","article-title":"Borderline epithelial tumors of the ovary","volume":"18","author":"W R Hart","year":"2005","journal-title":"Mod Pathol"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.tjog.2016.04.005","article-title":"The feasibility of fertility-sparing surgery in treating advanced-stage borderline ovarian tumors: a meta-analysis","volume":"55","author":"Y Huang","year":"2016","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.fertnstert.2004.10.009","article-title":"Fertility after conservative treatment for borderline ovarian tumors: a French multicenter study","volume":"83","author":"R Fauvet","year":"2005","journal-title":"Fertil Steril"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1245\/s10434-011-2039-y","article-title":"Behavior of serous borderline ovarian tumors with and without micropapillary patterns: results of a French multicenter study","volume":"19","author":"R Fauvet","year":"2012","journal-title":"Ann Surg Oncol"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1016\/S1470-2045(11)70288-1","article-title":"Borderline ovarian tumour: pathological diagnostic dilemma and risk factors for invasive or lethal recurrence","volume":"13","author":"P Morice","year":"2012","journal-title":"Lancet Oncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bpobgyn.2016.08.007","article-title":"Pathology of borderline and invasive cancers","volume":"41","author":"J Prat","year":"2017","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"05","key":"ref11","first-page":"471","article-title":"Diagnosis and treatment of borderline ovarian neoplasms \u201cthe state of the art.\u201d","volume":"30","author":"C Trop\u00e9","year":"2009","journal-title":"Eur J Gynaecol Oncol"},{"issue":"06","key":"ref12","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s00404-016-4174-y","article-title":"Necessity of appendectomy for mucinous borderline ovarian tumors. 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