{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:42:41Z","timestamp":1761522161310,"version":"build-2065373602"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":99,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ortop (Sao Paulo)"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Resumo<\/jats:title>\n                  <jats:p>Comparar a efic\u00e1cia e a seguran\u00e7a de interven\u00e7\u00f5es cir\u00fargicas e injet\u00e1veis para tratamento da contratura de Dupuytren (CD) por meio de revis\u00e3o sistem\u00e1tica e metodologia de metan\u00e1lise em rede.<\/jats:p>\n                  <jats:p>Este protocolo segue as diretrizes Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) e est\u00e1 registrado no banco de dados The International Prospective Register of Systematic Reviews (PROSPERO). Devem ser inclu\u00eddos estudos cl\u00ednicos randomizados com pacientes adultos com CD e submetidos a interven\u00e7\u00f5es cir\u00fargicas (ex.: fasciectomia e fasciotomia) ou injet\u00e1veis (ex.: colagenase e corticosteroides). Uma busca abrangente deve ser conduzida nas bases de dados MEDLINE, CENTRAL, EMBASE, LILACS, IBECS e registros de estudos cl\u00ednicos, sem restri\u00e7\u00f5es de idioma ou data. Dois revisores devem realizar a triagem, extra\u00e7\u00e3o de dados e avalia\u00e7\u00e3o de risco de vi\u00e9s (RoB2) de forma independente. Os desfechos prim\u00e1rios devem incluir melhora funcional e efeitos adversos. Os desfechos secund\u00e1rios devem incluir recidiva, amplitude de movimento e dor. A s\u00edntese de dados deve envolver metan\u00e1lises pareadas e de rede de efeitos aleat\u00f3rios e a certeza da evid\u00eancia deve ser avaliada de acordo com a abordagem Grading of Recommendation, Assessment, Development and Evaluation (GRADE). As an\u00e1lises de subgrupos devem explorar a heterogeneidade com base em vari\u00e1veis cl\u00ednicas e metodol\u00f3gicas.<\/jats:p>\n                  <jats:p>Esta proposta de revis\u00e3o pretende gerar estimativas comparativas de efic\u00e1cia e seguran\u00e7a em todas as interven\u00e7\u00f5es eleg\u00edveis, incorporando evid\u00eancias diretas e indiretas. Os desfechos funcionais devem ser sintetizados usando uma hierarquia predefinida de medidas de desfecho relatadas pelo paciente (PROMs, do ingl\u00eas patient-reported outcome measures) e os tratamentos devem ser classificados com base nos perfis de efic\u00e1cia e seguran\u00e7a.<\/jats:p>\n                  <jats:p>Esta revis\u00e3o sistem\u00e1tica visa preencher lacunas de evid\u00eancias atuais comparando todas as interven\u00e7\u00f5es relevantes para o tratamento da CD, apoiando a tomada de decis\u00e3o cl\u00ednica por meio de s\u00edntese robusta de resultados funcionais e de seguran\u00e7a.<\/jats:p>","DOI":"10.1055\/s-0045-1811596","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T23:09:26Z","timestamp":1757372966000},"page":"001-008","source":"Crossref","is-referenced-by-count":0,"title":["Interven\u00e7\u00f5es cir\u00fargicas e injet\u00e1veis na contratura de Dupuytren: protocolo de revis\u00e3o 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dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Disciplina de Cirurgia da M\u00e3o e Membro Superior, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1718-6281","authenticated-orcid":false,"given":"Vinicius Tassoni","family":"Civile","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Sa\u00fade Baseada em Evid\u00eancia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2168-8927","authenticated-orcid":false,"given":"Nelson","family":"Carvas Junior","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Sa\u00fade Baseada em Evid\u00eancia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, 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