{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T09:22:44Z","timestamp":1772616164667,"version":"3.50.1"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":61,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sinonasal papilloma is the most common benign tumor of the nasal cavity, with the inverted subtype being the most frequent. Its etiology remains highly controversial, but Human Papillomavirus (HPV) is believed to be associated with its pathogenesis. In addition to being locally aggressive, this tumor is characterized by high recurrence rates and malignant transformation potential.<\/jats:p>\n                  <jats:p>To describe the clinical and epidemiological profile of patients diagnosed with sinonasal papilloma who underwent surgery at a University Hospital.<\/jats:p>\n                  <jats:p>A cross-sectional study was performed analyzing the profile of patients diagnosed with sinonasal papilloma who underwent surgical treatment between January 1, 2021, and December 31, 2023. Variables such as sociodemographic, symptoms, smoking history, tumor location, Krouse staging, surgical techniques, histological subtypes, recurrence, and malignant transformation were analyzed.<\/jats:p>\n                  <jats:p>A higher prevalence was observed among women (52.4%), with a mean age of 54.2\u2009\u00b1\u200912 years old, and without a history of smoking (61.9%). Nasal obstruction was the most reported symptom, with the left nasal cavity being more frequently affected. Most cases were classified as Krouse stage T3, and 85.7% of all analyzed cases were managed exclusively through endoscopic approaches. Inverted papilloma was the most common subtype (66.7%). Only 9.5% and 4.8% of patients experienced recurrence and malignant transformation, respectively.<\/jats:p>\n                  <jats:p>Sinonasal papilloma was more prevalent in middle-aged women with no history of smoking. The diagnosis and treatment of sinonasal papilloma remain delayed due to nonspecific symptoms and limited access to specialized healthcare in Brazil. Long-term follow-up is crucial for monitoring potential recurrence and malignant transformation.<\/jats:p>","DOI":"10.1055\/s-0045-1811638","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T05:26:46Z","timestamp":1772602006000},"page":"001-006","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Epidemiological Profile of Patients with Sinonasal Papilloma in a University Hospital"],"prefix":"10.1055","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1012-1127","authenticated-orcid":false,"given":"Sanderson Endrew Gomes","family":"Le\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Hospital Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4207-3390","authenticated-orcid":false,"given":"Michelle Queiroz Aguiar","family":"Brasil","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Hospital Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4328-0159","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Co\u00ealho Neto","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Hospital Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5264-6642","authenticated-orcid":false,"given":"Carolina Cincur\u00e1","family":"Barreto","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Hospital Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil"},{"name":"School of Medicine, Universidade Federal da Bahia, Salvador, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5003-0828","authenticated-orcid":false,"given":"Marcus Miranda","family":"Lessa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Hospital Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil"},{"name":"School of Medicine, Universidade Federal da Bahia, Salvador, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5038-7977","authenticated-orcid":false,"given":"Clara M\u00f4nica Figueredo de","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Hospital Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil"},{"name":"Department of Otorhinolaryngology, Universidade Federal do Sul da Bahia, Teixeira de Freitas, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"ref1","first-page":"991","volume-title":"Tratado de otorrinolaringologia","author":"S SN Pignatari","year":"2018","edition":"3rd ed."},{"issue":"02","key":"ref2","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1177\/014556130608500201","article-title":"World Health Organization classification of tumours: pathology and genetics of head and neck tumours","volume":"85","author":"L Thompson","year":"2006","journal-title":"Ear Nose Throat J"},{"issue":"06","key":"ref3","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1002\/lio2.308","article-title":"Sinonasal oncocytic papilloma - 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Gallega."},{"issue":"05","key":"ref14","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1097\/COC.0b013e318064c711","article-title":"Inverted papilloma of the nasal cavity and paranasal sinuses","volume":"30","author":"W M Mendenhall","year":"2007","journal-title":"Am J Clin Oncol"},{"issue":"01","key":"ref15","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.wjorl.2016.11.004","article-title":"Etiology of sinonasal inverted papilloma: A narrative review","volume":"3","author":"M J Wang","year":"2016","journal-title":"World J Otorhinolaryngol Head Neck Surg"},{"issue":"02","key":"ref16","doi-asserted-by":"publisher","first-page":"79","DOI":"10.2500\/ajra.2016.30.4272","article-title":"Smoking, not human papilloma virus infection, is a risk factor for recurrence of sinonasal inverted papilloma","volume":"30","author":"H J Roh","year":"2016","journal-title":"Am J Rhinol 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