{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T23:30:17Z","timestamp":1781393417886,"version":"3.54.1"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic obstructive pulmonary disease (COPD) affects lung function, but its impact on vocal function remains understudied.<\/jats:p>\n                  <jats:p>To investigate the relationship involving COPD severity and vocal acoustic parameters and to assess the correlations regarding acoustic measures and pulmonary function tests in clinically stable COPD patients.<\/jats:p>\n                  <jats:p>The present observational study included 40 COPD patients diagnosed according to the 2023 guidelines of the Global Initiative for Chronic Obstructive Lung Disease (GOLD). All patients underwent spirometry, an otorhinolaryngological examination, and acoustic voice analysis, including fundamental frequency (F0), harmonics-to-noise ratio (HNR), jitter, and shimmer. The Arabic version of the Voice-Related Quality of Life (V-RQOL) questionnaire was used to assess voice-related impairment.<\/jats:p>\n                  <jats:p>The sample had a mean age of 65\u2009\u00b1\u20096 years, with 92.5% of male subjects. Dysphonia was observed in 57.5% of the patients. Laryngoscopic findings included Reinke's edema (42.5%), laryngitis (25%), polypoid degeneration (20%), and phonasthenia (12.5%). The acoustic analysis revealed significant negative correlations involving pulmonary function parameters and vocal measures. The regression analysis demonstrated forced expiratory volume in the first second (FEV1) and FEV1\/forced vital capacity (FVC) as significant predictors of mean pitch, jitter, and shimmer, with each unit increase in FEV1 associated with a decrease in these acoustic measures (p\u2009&lt;\u20090.001).<\/jats:p>\n                  <jats:p>The severity of COPD is significantly associated with acoustic voice alterations, with disease progression leading to measurable impairments in vocal function. These findings highlight the importance of voice assessment in COPD management.<\/jats:p>","DOI":"10.1055\/s-0045-1811696","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:08:54Z","timestamp":1762906134000},"page":"001-008","source":"Crossref","is-referenced-by-count":4,"title":["Study of the Impact of Chronic Obstructive Pulmonary Disease on Vocal Function"],"prefix":"10.1055","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3243-9582","authenticated-orcid":false,"given":"Omnia Zakaria","family":"Elshebl","sequence":"additional","affiliation":[{"name":"Department of Phoniatrics and Otorhinolaryngology, Faculty of Medicine, Benha University, Benha, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa Eldesouky","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Faculty of Medicine, Benha University, Benha, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salwa Ahmed Abdelhay","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Phoniatrics and Otorhinolaryngology, Faculty of Medicine, Benha University, Benha, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.ccm.2020.06.007","article-title":"Definition, Causes, Pathogenesis, and Consequences of Chronic Obstructive Pulmonary Disease Exacerbations","volume":"41","author":"A I Ritchie","year":"2020","journal-title":"Clin Chest Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1016\/s0140-6736(22)00470-6","article-title":"Chronic obstructive pulmonary disease","volume":"399","author":"S A Christenson","year":"2022","journal-title":"Lancet"},{"issue":"13","key":"ref3","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.3390\/jcm10132889","article-title":"Chronic Obstructive Pulmonary Disease: Epidemiology, Biomarkers, and Paving the Way to Lung Cancer","volume":"10","author":"K Szalontai","year":"2021","journal-title":"J Clin Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.ejcdt.2014.03.006","article-title":"Voice changes in patients with chronic obstructive pulmonary disease","volume":"63","author":"E E Mohamed","year":"2014","journal-title":"Egypt J Chest Dis Tuberc"},{"issue":"01","key":"ref6","doi-asserted-by":"publisher","first-page":"154","DOI":"10.21608\/MJMR.2022.222879","article-title":"Voice Problems in Patients with Chronic Obstructive Pulmonary Disease","volume":"30","author":"H M Mohamed","year":"2019","journal-title":"Minia J Med Res"},{"issue":"01","key":"ref7","doi-asserted-by":"publisher","first-page":"38","DOI":"10.4103\/lungindia.lungindia_145_18","article-title":"Physical signs in patients with chronic obstructive pulmonary disease","volume":"36","author":"M Sarkar","year":"2019","journal-title":"Lung India"},{"issue":"01","key":"ref8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1055\/s-0033-1358586","article-title":"Association between Lung Function and Vocal Affections Arising from Tobacco Consumption","volume":"18","author":"K W Santos","year":"2014","journal-title":"Int Arch Otorhinolaryngol"},{"issue":"04","key":"ref9","doi-asserted-by":"publisher","first-page":"2300239","DOI":"10.1183\/13993003.00239-2023","article-title":"Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary","volume":"61","author":"A Agust\u00ed","year":"2023","journal-title":"Eur Respir J"},{"issue":"08","key":"ref10","doi-asserted-by":"publisher","first-page":"e70","DOI":"10.1164\/rccm.201908-1590ST","article-title":"Standardization of Spirometry 2019 Update. 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