{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:39:20Z","timestamp":1777927160341,"version":"3.51.4"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nucl Med"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an unstable expansion of CAG trinucleotide repeats that lead to progressive degeneration of postsynaptic striatal medium-spiny GABAergic neurons. We report a case of abnormal [123I] Ioflupane single-photon emission computed tomography\/computed tomography (DaTSCAN) and a subsequent genetic test confirming HD. A 68-year-old man presented with progressive memory difficulties, auditory hallucinations, nightmares, suicidal thoughts, low mood, and involuntary limb movements. DaTSCAN showed borderline reduced putaminal binding ratios bilaterally, more prominent on the left side, and a low putamen-to-caudate ratio suggesting degenerative parkinsonism. Genetic testing revealed one pathogenic expansion (40\/17 CAG repeats), confirming HD. Postsynaptic dopaminergic involvement has previously been documented in postmortem studies. However, an emerging in vivo research also suggests presynaptic dopaminergic involvement. While genetic testing remains the gold standard for diagnosis of HD, DaTSCAN may play a role in assessing dopamine transporter activity and tracking the progression of neurodegeneration in HD.<\/jats:p>","DOI":"10.1055\/s-0045-1812051","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:30:17Z","timestamp":1759617017000},"page":"046-050","source":"Crossref","is-referenced-by-count":0,"title":["Huntington's Disease with Parkinson-Like Symptoms and Abnormal [123I] Ioflupane SPECT-CT (DaTs): A Case Report and Literature Review"],"prefix":"10.1055","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3371-1576","authenticated-orcid":false,"given":"Sarah","family":"Amro","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Royal Sussex County Hospital, Brighton, United Kingdom"},{"name":"Department of Nuclear Medicine, University Hospitals Sussex NHS Foundation Trust, Brighton, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2407-5126","authenticated-orcid":false,"given":"Chamani","family":"Punchihewa","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospitals Sussex NHS Foundation Trust, Brighton, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edina","family":"Bravo","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospitals Sussex NHS Foundation Trust, Brighton, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Dizdarevic","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Royal Sussex County Hospital, Brighton, United Kingdom"},{"name":"Department of Nuclear Medicine, Brighton and Sussex Medical School, Brighton, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,10,4]]},"reference":[{"issue":"16","key":"ref1","doi-asserted-by":"crossref","first-page":"13021","DOI":"10.3390\/ijms241613021","article-title":"From pathogenesis to therapeutics: a review of 150 years of Huntington's disease research","volume":"24","author":"A Jiang","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1750-1172-5-40","article-title":"Huntington's disease: a clinical review","volume":"5","author":"R A Roos","year":"2010","journal-title":"Orphanet J Rare Dis"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"154","DOI":"10.2967\/jnumed.111.100784","article-title":"SNM practice guideline for dopamine transporter imaging with 123I-ioflupane SPECT 1.0","volume":"53","author":"D SW Djang","year":"2012","journal-title":"J Nucl Med"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1002\/jnr.24495","article-title":"Dysfunctional striatal dopamine signaling in Huntington's disease","volume":"97","author":"E T Koch","year":"2019","journal-title":"J Neurosci Res"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s40336-024-00646-z","article-title":"PET imaging of dopaminergic system and clinical applications","volume":"12","author":"I Sarikaya","year":"2024","journal-title":"Clin Transl Imaging"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1552-6569.2011.00671.x","article-title":"SPECT study of the nigrostriatal dopaminergic system in Huntington's disease","volume":"23","author":"W J Hwang","year":"2013","journal-title":"J Neuroimaging"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.clineuro.2010.07.014","article-title":"Does reduced [(123)I]-FP-CIT binding in Huntington's disease suggest pre-synaptic dopaminergic involvement?","volume":"112","author":"J Gamez","year":"2010","journal-title":"Clin Neurol Neurosurg"},{"issue":"09","key":"ref8","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.parkreldis.2013.05.005","article-title":"Nigral involvement and nigrostriatal dysfunction in Huntington's disease: evidences from an MRI and SPECT study","volume":"19","author":"L Kiferle","year":"2013","journal-title":"Parkinsonism Relat Disord"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"e227","DOI":"10.1097\/RLU.0b013e31828162cd","article-title":"Progressive presynaptic dopaminergic deterioration in Huntington disease: a [123I]-FP-CIT SPECT two-year follow-up study","volume":"39","author":"J Gamez","year":"2014","journal-title":"Clin Nucl Med"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1002\/acn3.51474","article-title":"The case of a 29-year-old man with psychiatric illness and parkinsonism","volume":"8","author":"D Larson","year":"2021","journal-title":"Ann Clin Transl Neurol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.parkreldis.2020.01.008","article-title":"Huntington disease like 2 (HDL-2) with parkinsonism and abnormal DAT-SPECT - a novel observation","volume":"71","author":"E Mulroy","year":"2020","journal-title":"Parkinsonism Relat Disord"},{"issue":"07","key":"ref12","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1016\/j.radcr.2022.03.109","article-title":"Dual phase 18F-FP CIT PET and 99mTc- ECD SPECT findings of Huntington's disease","volume":"17","author":"K Chun","year":"2022","journal-title":"Radiol Case Rep"},{"issue":"04","key":"ref13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3233\/JHD-150171","article-title":"PET imaging in Huntington's disease","volume":"4","author":"A A Roussakis","year":"2015","journal-title":"J Huntingtons Dis"},{"issue":"14","key":"ref14","doi-asserted-by":"crossref","first-page":"P3.031","DOI":"10.1212\/WNL.84.14_supplement.P3.031","article-title":"A movement disorders paradox: case report of a patient with gene-positive Huntington's disease who presented with DaTScan positive and levodopa responsive Parkinson's disease (P3.031)","volume":"84","author":"R Hadden","year":"2015","journal-title":"Neurology"}],"container-title":["World Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0045-1812051.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:36:31Z","timestamp":1777674991000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0045-1812051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,4]]},"references-count":14,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2026,5,1]]},"published-print":{"date-parts":[[2026,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0045-1812051","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1450-1147","1607-3312"],"issn-type":[{"value":"1450-1147","type":"print"},{"value":"1607-3312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,4]]}}}