{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T23:58:15Z","timestamp":1761609495236,"version":"build-2065373602"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Intracranial germ cell tumors (iGCTs) often lead to endocrine-metabolic complications; however, their long-term effects are not well understood and characterized.<\/jats:p>\n                  <jats:p>To evaluate endocrine-metabolic dysfunction before and after iGCTs treatment.<\/jats:p>\n                  <jats:p>The present retrospective study included 99 patients with iGCTs treated at a tertiary hospital. Endocrine and metabolic parameters were assessed before and after treatment.<\/jats:p>\n                  <jats:p>A male sex predominance was observed (81.8%). The leading site was pineal (44.4%), and 67.7% of the tumors were classified as germinoma. Radiotherapy was performed in 82.8% of the cases (58.5% cranial and 41.5% craniospinal). At diagnosis, the incidences of gonadotropin-independent precocious puberty and diabetes insipidus were 15.2% and 48.2%, respectively. Significant endocrine-metabolic changes in patients with iGCTs were observed after treatment, as 72.3% of patients required hormone replacement, 60% had growth hormone deficiency, and dyslipidemia was observed in 49.2% of patients. Overweight increased from 24.2 to 35.4% after treatment, while obesity increased from 10.1 to 15.4%. There was an increase in growth hormone deficiency, hypothyroidism, and hypogonadism, while prolactin levels significantly decreased after treatment. An older age at diagnosis was associated with a lower risk of hypocortisolism (p\u2009=\u20090.005). Regarding sex, females had lower height Z-scores and a higher frequency of growth hormone deficiency compared with males. Tumor-related mortality was reported in 22.2% of patients, occurring on average 2.2 years postdiagnosis.<\/jats:p>\n                  <jats:p>The high prevalence of endocrine-metabolic complications following radiotherapy highlights the necessity of ongoing monitoring. The treatment demonstrated significant efficacy, as reflected by the notable survival rates. Early intervention is crucial for improving the long-term quality of life.<\/jats:p>","DOI":"10.1055\/s-0045-1812300","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T23:53:23Z","timestamp":1761609203000},"page":"001-008","source":"Crossref","is-referenced-by-count":0,"title":["Beyond the tumor: endocrine and metabolic dysregulation in intracranial germ cell tumors \u2013 a retrospective cohort study"],"prefix":"10.1055","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5697-6772","authenticated-orcid":false,"given":"Mayco Jos\u00e9 Reinaldi","family":"Serra","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo SP, Brazil."},{"name":"Universidade Lusiada, Santos SP, Brazil."},{"name":"Grupo de Apoio ao Adolescente e \u00e0 Crian\u00e7a com C\u00e2ncer, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1974-0925","authenticated-orcid":false,"given":"Angela Maria","family":"Spinola-Castro","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo SP, Brazil."},{"name":"Grupo de Apoio ao Adolescente e \u00e0 Crian\u00e7a com C\u00e2ncer, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7759-9125","authenticated-orcid":false,"given":"Nasjla Saba da","family":"Silva","sequence":"additional","affiliation":[{"name":"Grupo de Apoio ao Adolescente e \u00e0 Crian\u00e7a com C\u00e2ncer, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3818-8876","authenticated-orcid":false,"given":"Andrea","family":"Cappellano","sequence":"additional","affiliation":[{"name":"Grupo de Apoio ao Adolescente e \u00e0 Crian\u00e7a com C\u00e2ncer, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2055-3756","authenticated-orcid":false,"given":"Paola Matiko Martins","family":"Okuda","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3001-0184","authenticated-orcid":false,"given":"Adriana Aparecida","family":"Siviero-Miachon","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo SP, Brazil."},{"name":"Grupo de Apoio ao Adolescente e \u00e0 Crian\u00e7a com C\u00e2ncer, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"iii1","DOI":"10.1093\/neuonc\/noab200","article-title":"CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018","volume":"23","author":"Q T Ostrom","year":"2021","journal-title":"Neuro-oncol"},{"issue":"10","key":"ref2","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1002\/cncr.21430","article-title":"Primary pediatric brain tumors: statistics of Taipei VGH, Taiwan (1975-2004)","volume":"104","author":"T T Wong","year":"2005","journal-title":"Cancer"},{"issue":"04","key":"ref3","doi-asserted-by":"publisher","first-page":"e\u2013054051","DOI":"10.32635\/2176-9745.RBC.2023v69n4.4051","article-title":"Epidemiological, Clinical, and Pathological Analysis of Children with Central Nervous System Neoplasms Treated 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