{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:22:16Z","timestamp":1788481336549,"version":"build-2803163510"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mechanical thrombectomy (MT) is a key therapy for acute ischemic stroke (AIS), improving survival and functional outcomes. However, the variability in results highlights the need for predictive markers to refine patient selection. Biomarkers reflecting inflammation and metabolic stress are gaining recognition for their role in AIS and MT outcomes.<\/jats:p>\n                  <jats:p>To systematically review and synthesize the evidence on biomarkers associated with clinical outcomes in AIS patients undergoing MT. Specific aims include evaluating their relationship with functional recovery (mRS), mortality, infarct volume, hemorrhagic transformation, and complications such as malignant brain edema (MBE) and delayed cerebral ischemia (DCI).<\/jats:p>\n                  <jats:p>A systematic review of the literature was conducted in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement to identify studies evaluating biomarkers in MT. The PubMed and Embase databases were searched using the following terms: (Marker OR biomarker*) AND (Mechanical Thrombectomy OR endovascular) AND Stroke.<\/jats:p>\n                  <jats:p>Of 2,834 articles identified, 86 met inclusion criteria. Several biomarkers, such as C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), adenosine deaminase (ADA), neuron-specific enolase (NSE), and matrix metalloproteinase-9 (MMP-9), were consistently associated with worse functional outcomes, increased mortality, and higher risk of complications including hemorrhagic transformation and MBE.<\/jats:p>\n                  <jats:p>Multiple biomarkers demonstrate prognostic value in AIS patients undergoing MT. These findings may support risk stratification and individualized care, though further prospective studies are needed to integrate these biomarkers into the clinical practice.<\/jats:p>","DOI":"10.1055\/s-0045-1812301","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T23:58:02Z","timestamp":1761955082000},"page":"001-007","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic biomarkers in ischemic stroke treated with mechanical thrombectomy: a systematic review"],"prefix":"10.1055","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1465-6265","authenticated-orcid":false,"given":"Rodrigo Fellipe","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Estrutural e Funcional, S\u00e3o Paulo, SP, Brazil."},{"name":"University of Toronto, Department of Neurosurgery, Division of Interventional Neuroradiology, St. Michael's Hospital, Toronto, ON, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3749-9218","authenticated-orcid":false,"given":"Raquel Cristina Trovo","family":"Hidalgo","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto, Departamento de Neurorradiologia Intervencionista, S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6861-0505","authenticated-orcid":false,"given":"Savio","family":"Batista","sequence":"additional","affiliation":[{"name":"Emory University, Department of Neurology, Atlanta, GA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3209-5733","authenticated-orcid":false,"given":"J\u00falia Belone","family":"Lopes","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto, Departamento de Oncologia Cl\u00ednica, S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil."},{"name":"University of Toronto, Department of Medical Oncology, Sunnybrook Health Science Centre, Toronto, ON, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3187-0220","authenticated-orcid":false,"given":"Gabriel Paulo","family":"Mantovani","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre, Departamento de Neurologia, Porto Alegre, RS, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2839-7828","authenticated-orcid":false,"given":"Pedro Henrique Matos","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica, Departamento de Medicina, Salvador, BA, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9835-9850","authenticated-orcid":false,"given":"Andr\u00e9","family":"Nishizima","sequence":"additional","affiliation":[{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica, Departamento de Medicina, Salvador, BA, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1148-7085","authenticated-orcid":false,"given":"Anderson Silva","family":"Corin","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas, Departamento de Medicina, Pelotas, RS, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8161-6430","authenticated-orcid":false,"given":"Lucas","family":"Macedo","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia, Departamento de Medicina, Bras\u00edlia, DF, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8359-6763","authenticated-orcid":false,"given":"Mariana Let\u00edcia de Bastos","family":"Maximiano","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Departamento de Medicina, Rio de Janeiro, RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1840-2953","authenticated-orcid":false,"given":"Pedro Lucas Machado","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Instituto de Educa\u00e7\u00e3o M\u00e9dica, Departamento de Medicina, Angra dos Reis, RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4847-2728","authenticated-orcid":false,"given":"Julia Camargo","family":"Ricci","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista \"J\u00falio de Mesquita Filho\", Instituto de Bioci\u00eancias, Letras e Ci\u00eancias Exatas, S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0918-2130","authenticated-orcid":false,"given":"Sonia Maria","family":"Oliani","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Estrutural e Funcional, S\u00e3o Paulo, SP, Brazil."},{"name":"Universidade Estadual Paulista \"J\u00falio de Mesquita Filho\", Instituto de Bioci\u00eancias, Letras e Ci\u00eancias Exatas, S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"publisher","first-page":"e000407","DOI":"10.1136\/bmjmed-2022-000407","article-title":"Advances in mechanical thrombectomy for acute ischaemic stroke","volume":"2","author":"O 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