{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:18:07Z","timestamp":1783034287396,"version":"3.54.6"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nucl Med"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Physiologic 18F-fluorodeoxyglucose (FDG) uptake in brown adipose tissue (BAT) is a recognized source of false-positive findings on positron emission tomography (PET) scans, typically presenting as symmetric, multifocal activity in fat-density tissue. We report a case of a 30-year-old woman with left-sided cervical swelling and unilateral, left-sided FDG uptake mimicking malignancy, but without corresponding computed tomography abnormalities. The patient's history included right-sided mediastinal ganglioneuroma resection in childhood, resulting in Horner syndrome. Hybrid PET\/magnetic resonance (MR) imaging with image fusion definitively localized the FDG activity to left-sided BAT, confirming the tissue origin and linking the unilaterality to sympathetic denervation from prior right stellate ganglion disruption. This case illustrates that hybrid PET\/MR can resolve diagnostic uncertainty in atypical BAT presentations and highlights the importance of recognizing altered BAT metabolism after sympathetic injury to avoid misinterpretation of PET findings.<\/jats:p>","DOI":"10.1055\/s-0045-1812308","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T23:08:46Z","timestamp":1761347326000},"page":"175-177","source":"Crossref","is-referenced-by-count":0,"title":["Unilateral Brown Fat FDG Uptake after Childhood Sympathectomy Mimicking Malignancy Resolved by Hybrid PET\/MR Image Fusion"],"prefix":"10.1055","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2538-3074","authenticated-orcid":false,"given":"Freimut Dankwart Eberhard","family":"Juengling","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3365-7946","authenticated-orcid":false,"given":"Judith","family":"Hafer","sequence":"additional","affiliation":[{"name":"Department of Oncology, University Hospital of Basel, Basel, Kanton Basel-Stadt, Basel-Stadt, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alin","family":"Chirindel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Basel, Kanton Basel-Stadt, Basel-Stadt, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s00259-002-0902-6","article-title":"Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region","volume":"29","author":"T F Hany","year":"2002","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"08","key":"ref2","first-page":"1267","article-title":"\u201cUSA-Fat\u201d: prevalence is related to ambient outdoor temperature-evaluation with 18F-FDG PET\/CT","volume":"44","author":"C Cohade","year":"2003","journal-title":"J Nucl Med"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1139\/y90-102","article-title":"Role of neural input in photoperiod-induced changes in hamster brown adipose tissue","volume":"68","author":"M Desautels","year":"1990","journal-title":"Can J Physiol Pharmacol"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1139\/y74-009","article-title":"Adrenergic innervation of brown adipose tissue from the ground squirrel (Citellus richardsonii)","volume":"52","author":"M K Cottle","year":"1974","journal-title":"Can J Physiol Pharmacol"},{"issue":"07","key":"ref5","first-page":"1189","article-title":"Intense (18)F-FDG uptake in brown fat can be reduced pharmacologically","volume":"45","author":"M Tatsumi","year":"2004","journal-title":"J Nucl Med"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/08880018.2017.1338806","article-title":"Pilot study of propranolol premedication to reduce FDG uptake in brown adipose tissue on PET scans of adolescent and young adult oncology patients","volume":"34","author":"A George","year":"2017","journal-title":"Pediatr Hematol Oncol"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2967\/jnumed.113.121327","article-title":"Propranolol inhibits glucose metabolism and 18F-FDG uptake of breast cancer through posttranscriptional downregulation of hexokinase-2","volume":"55","author":"F Kang","year":"2014","journal-title":"J Nucl Med"},{"key":"ref8","first-page":"E239","article-title":"Influence of subdiaphragmatic vagotomy and brown fat sympathectomy on thermogenesis in rats","volume":"249","author":"P L Andrews","year":"1985","journal-title":"Am J Physiol"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1097\/RLU.0b013e3181f49ff8","article-title":"Interesting image. Unilateral F-18 FDG uptake in the neck, in patients with sympathetic denervation","volume":"35","author":"L Lebron","year":"2010","journal-title":"Clin Nucl Med"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"653","DOI":"10.2170\/jjphysiol.42.653","article-title":"Importance of sympathetic nerves for the stimulatory effect of cold exposure on glucose utilization in brown adipose tissue","volume":"42","author":"A Takahashi","year":"1992","journal-title":"Jpn J Physiol"}],"container-title":["World Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0045-1812308.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:38:02Z","timestamp":1783031882000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0045-1812308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,24]]},"references-count":10,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2026,7,2]]},"published-print":{"date-parts":[[2026,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0045-1812308","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1450-1147","1607-3312"],"issn-type":[{"value":"1450-1147","type":"print"},{"value":"1607-3312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,24]]}}}