{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T23:06:11Z","timestamp":1774998371536,"version":"3.50.1"},"reference-count":73,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin intervent Radiol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endovascular therapy (EVT) has transformed acute ischemic stroke management, achieving successful vessel recanalization in approximately 70 to 80% of patients. Despite these advances, recommendations regarding medical management in the setting of EVT remain complex and variable across institutions. In keeping, this work presents a comprehensive overview of medical management in the setting of EVT is presented to provide direction and clarity regarding essential components of management, thus promoting positive outcomes and minimizing morbidity\/mortality. In the preprocedural setting, intravenous thrombolysis remains standard therapy for eligible patients, while periprocedural anticoagulation and antiplatelet therapies are generally discouraged due to increased risk of hemorrhage and lack of functional benefit, with select exceptions such as emergency stenting for tandem lesions. Postprocedural blood pressure management should be individualized, with consensus favoring systolic blood pressure targets below 160\u2009mm Hg after reperfusion, noting that higher targets (up to 180\u2009mm Hg) may be considered in cases of incomplete reperfusion, and excessively low targets (&lt;120\u2009mm Hg) may be detrimental to maintaining adequate cerebral perfusion. Ongoing research is refining optimal management strategies to improve outcomes in this population further.<\/jats:p>","DOI":"10.1055\/s-0045-1812856","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T23:38:56Z","timestamp":1762385936000},"page":"572-581","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacologic and Medical Management in the Setting of Endovascular Stroke Interventions: A Comprehensive Overview to Management"],"prefix":"10.1055","volume":"42","author":[{"given":"Vanessa","family":"Veltre","sequence":"additional","affiliation":[{"name":"Department of Radiology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Sozio","sequence":"additional","affiliation":[{"name":"Department of Radiology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Herrera","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Mensah","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Hoost","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emad","family":"Nourollah-Zadeh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudipta","family":"Roychowdhury","sequence":"additional","affiliation":[{"name":"Department of Radiology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sri H.","family":"Sundararajan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1161\/STR.0000000000000086","article-title":"Scientific rationale for the inclusion and exclusion criteria for intravenous alteplase in acute ischemic stroke: a statement for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"47","author":"B M Demaerschalk","year":"2016","journal-title":"Stroke"},{"issue":"08","key":"ref2","first-page":"e93","article-title":"Heart disease and stroke statistics-2023 update: a report from the American Heart Association","volume":"147","author":"C W Tsao","year":"2023","journal-title":"Circulation"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"e344","DOI":"10.1161\/STR.0000000000000211","article-title":"Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"50","author":"W J Powers","year":"2019","journal-title":"Stroke"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/S0140-6736(16)00163-X","article-title":"Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials","volume":"387","author":"M Goyal","year":"2016","journal-title":"Lancet"},{"issue":"08","key":"ref5","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart disease and stroke statistics-2021 update: a report from the American Heart Association","volume":"143","author":"S S Virani","year":"2021","journal-title":"Circulation"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1161\/01.STR.12.6.723","article-title":"Thresholds in cerebral ischemia - 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