{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:06:06Z","timestamp":1765411566977,"version":"3.46.0"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":70,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ortop (Sao Paulo)"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To compare short-term complication rates of small-volume adipose tissue harvesting for micro-fragmented adipose tissue (mFAT) knee injections performed by orthopedic surgeons with those performed by plastic surgeons. Additionally, to evaluate the orthopedic surgeon's learning curve.<\/jats:p>\n                  <jats:p>The present case-control study enrolled patients with knee osteoarthritis. All patients underwent a single-stage procedure consisting of abdominal adipose tissue harvesting, processing of the extracted material using the Lipogems (Lipogems International SpA) device to obtain mFAT, which was then injected intra-articularly into the knee. The patients were divided into a test group, with harvesting being performed by a recently trained orthopedic surgeon, and a control group, in which the procedure was performed by an experienced plastic surgeon. Short-term adverse effects, minor and major complications related to harvesting, were assessed intraoperatively and at 7-day follow-up.<\/jats:p>\n                  <jats:p>No major complications (fat embolism, thromboembolic events, abdominal perforation, wound infection, dehiscence, or cosmetic changes) were observed in either group. Abdominal discomfort during harvesting, classified as a minor complication, showed no statistically significant difference between groups (p\u2009=\u20090.362). Postoperative adverse effects, such as abdominal ecchymosis (p\u2009=\u20090.362) and discomfort (p\u2009=\u20090.342), were equivalent in both groups and resolved within 7 days.<\/jats:p>\n                  <jats:p>The present pilot study suggests that, with adequate training, orthopedic surgeons can perform small-volume adipose tissue harvesting with low complication rates, comparable to those achieved by plastic surgeons experienced in liposuction.<\/jats:p>","DOI":"10.1055\/s-0045-1813003","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:01:42Z","timestamp":1765411302000},"page":"001-007","source":"Crossref","is-referenced-by-count":0,"title":["Fat Harvesting for Micro-Fragmented Adipose Tissue Injections: A Pilot Study Comparing Safety in Procedures Performed by Orthopedic and Plastic Surgeons"],"prefix":"10.1055","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-2712","authenticated-orcid":false,"given":"Bruno Butturi","family":"Varone","sequence":"additional","affiliation":[{"name":"Knee Group, Instituto de Ortopedia e Traumatologia, Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9818-4968","authenticated-orcid":false,"given":"Rodrigo Bernstein","family":"Conde","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Ciencia de la Salud Fundaci\u00f3n H. A. Barcel\u00f3, Facultad de Medicina, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8386-3121","authenticated-orcid":false,"given":"Chilan B. G.","family":"Leite","sequence":"additional","affiliation":[{"name":"Knee Group, Instituto de Ortopedia e Traumatologia, Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"},{"name":"Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5855-0975","authenticated-orcid":false,"given":"Pedro Nogueira","family":"Giglio","sequence":"additional","affiliation":[{"name":"Knee Group, Instituto de Ortopedia e Traumatologia, Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1715-4343","authenticated-orcid":false,"given":"Riccardo Gomes","family":"Gobbi","sequence":"additional","affiliation":[{"name":"Knee Group, Instituto de Ortopedia e Traumatologia, Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1999-9478","authenticated-orcid":false,"given":"Marco Kawamura","family":"Demange","sequence":"additional","affiliation":[{"name":"Knee Group, Instituto de Ortopedia e Traumatologia, Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"issue":"08","key":"ref1","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/acr2.11295","article-title":"The Prevalence of Knee Symptoms, Radiographic, and Symptomatic Osteoarthritis at Four Time Points: The Johnston County Osteoarthritis Project, 1999-2018","volume":"3","author":"A E Nelson","year":"2021","journal-title":"ACR Open Rheumatol"},{"issue":"03","key":"ref2","doi-asserted-by":"publisher","first-page":"504","DOI":"10.3390\/jpm13030504","article-title":"Intra-articular injection of autologous micro-fragmented adipose tissue for the treatment of knee osteoarthritis: a prospective interventional study","volume":"13","author":"Y Yu","year":"2023","journal-title":"J Pers Med"},{"issue":"08","key":"ref3","doi-asserted-by":"publisher","first-page":"3079","DOI":"10.1007\/s00167-022-07101-4","article-title":"Micro-fragmented adipose tissue (mFAT) associated with arthroscopic debridement provides functional improvement in knee osteoarthritis: a randomized controlled trial","volume":"31","author":"M Ulivi","year":"2023","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"03","key":"ref4","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2217\/rme-2018-0161","article-title":"Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial","volume":"14","author":"J Freitag","year":"2019","journal-title":"Regen Med"},{"issue":"05","key":"ref5","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1007\/s00264-018-4099-0","article-title":"Intra-articular injection of autologous adipose-derived stromal vascular fractions for knee osteoarthritis: a double-blind randomized self-controlled trial","volume":"43","author":"Z Hong","year":"2019","journal-title":"Int Orthop"},{"issue":"12","key":"ref6","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.3390\/genes10121051","article-title":"A 24-Month Follow-Up Study of the Effect of Intra-Articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis","volume":"10","author":"I Bori\u0107","year":"2019","journal-title":"Genes (Basel)"},{"issue":"12","key":"ref7","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.4252\/wjsc.v15.i12.1063","article-title":"Mid-term outcomes of microfragmented adipose tissue plus arthroscopic surgery for knee osteoarthritis: A randomized, active-control, multicenter clinical trial","volume":"15","author":"C Z Wu","year":"2023","journal-title":"World J Stem Cells"},{"issue":"02","key":"ref8","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.arthro.2024.08.037","article-title":"Microfragmented Adipose Tissue Injection Reduced Pain Compared With a Saline Control Among Patients With Symptomatic Osteoarthritis of the Knee During 1-Year Follow-Up: A Randomized Controlled Trial","volume":"41","author":"D L Richter","year":"2025","journal-title":"Arthroscopy"},{"issue":"06","key":"ref9","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3949\/ccjm.87a.19097","article-title":"Liposuction: Concepts, safety, and techniques in body-contouring surgery","volume":"87","author":"S Wu","year":"2020","journal-title":"Cleve Clin J Med"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3390\/genes8100270","article-title":"The Effect of Intra-articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis","volume":"8","author":"D Hudetz","year":"2017","journal-title":"Genes (Basel)"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3325\/cmj.2019.60.227","article-title":"Early results of intra-articular micro-fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study","volume":"60","author":"D Hudetz","year":"2019","journal-title":"Croat Med J"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0733-8635(18)30474-1","article-title":"The tumescent technique. Anesthesia and modified liposuction technique","volume":"8","author":"J A Klein","year":"1990","journal-title":"Dermatol Clin"},{"issue":"01","key":"ref13","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jcot.2018.10.021","article-title":"Microfragmented adipose injections in the treatment of knee osteoarthritis","volume":"10","author":"G A Malanga","year":"2019","journal-title":"J Clin Orthop Trauma"},{"issue":"03","key":"ref14","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s40778-016-0053-5","article-title":"Adipose Tissue and Mesenchymal Stem Cells: State of the Art and Lipogems\u00ae Technology Development","volume":"2","author":"C Tremolada","year":"2016","journal-title":"Curr Stem Cell Rep"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/22925503221078693","article-title":"Complications of Aesthetic Liposuction Performed in Isolation: A Systematic Literature Review and Meta-Analysis","volume":"32","author":"A Aljerian","year":"2024","journal-title":"Plast Surg (Oakv)"},{"issue":"03","key":"ref16","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/PRS.0000000000001498","article-title":"Is There a Safe Lipoaspirate Volume? A Risk Assessment Model of Liposuction Volume as a Function of Body Mass Index","volume":"136","author":"I Chow","year":"2015","journal-title":"Plast Reconstr Surg"},{"issue":"03","key":"ref17","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/j.1524-4725.1990.tb03961.x","article-title":"Tumescent technique for regional anesthesia permits lidocaine doses of 35\u2009mg\/kg for liposuction","volume":"16","author":"J A Klein","year":"1990","journal-title":"J Dermatol Surg Oncol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"75","DOI":"10.23750\/abm.v90i1-S.8084","article-title":"Mesenchymal Stem Cells injection in hip osteoarthritis: preliminary results","volume":"90","author":"C Dall'Oca","year":"2019","journal-title":"Acta Biomed"},{"issue":"131","key":"ref19","first-page":"56395","article-title":"Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus","author":"R D'Ambrosi","year":"2018","journal-title":"J Vis Exp"},{"issue":"10","key":"ref20","first-page":"A5565","article-title":"Treatment of osteoarthritis with autologous and microfragmented adipose tissue","volume":"66","author":"K W Barfod","year":"2019","journal-title":"Dan Med J"},{"issue":"05","key":"ref21","first-page":"e24823","article-title":"Safety and Efficacy of Injecting Mesenchymal Stem Cells Into a Human Knee Joint To Treat Osteoarthritis: A Systematic Review","volume":"14","author":"S I Shoukrie","year":"2022","journal-title":"Cureus"},{"issue":"11","key":"ref22","doi-asserted-by":"publisher","DOI":"10.12788\/ajo.2018.0098","article-title":"Safety and Efficacy of Percutaneous Injection of Lipogems Micro-Fractured Adipose Tissue for Osteoarthritic Knees","volume":"47","author":"J Panchal","year":"2018","journal-title":"Am J Orthop (Belle Mead NJ)"},{"issue":"01","key":"ref23","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s40634-017-0108-2","article-title":"Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis","volume":"4","author":"A Russo","year":"2017","journal-title":"J Exp Orthop"},{"issue":"01","key":"ref24","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s12891-018-2105-8","article-title":"Micro-fragmented adipose tissue injection associated with arthroscopic procedures in patients with symptomatic knee osteoarthritis","volume":"19","author":"G Cattaneo","year":"2018","journal-title":"BMC Musculoskelet Disord"},{"issue":"01","key":"ref25","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s40634-018-0169-x","article-title":"Autologous micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis: an update at 3\u2009year follow-up","volume":"5","author":"A Russo","year":"2018","journal-title":"J Exp Orthop"},{"issue":"09","key":"ref26","doi-asserted-by":"publisher","first-page":"3925","DOI":"10.1007\/s00402-023-05143-y","article-title":"Autologous microfragmented adipose tissue treatment of knee osteoarthritis demonstrates effectiveness in 68% of patients at 4-year follow-up","volume":"144","author":"F Onorato","year":"2024","journal-title":"Arch Orthop Trauma Surg"}],"container-title":["Revista Brasileira de Ortopedia"],"original-title":[],"language":"pt","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0045-1813003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:01:51Z","timestamp":1765411311000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0045-1813003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":26,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2025,11,4]]},"published-print":{"date-parts":[[2025,10]]}},"alternative-id":["s00451813003"],"URL":"https:\/\/doi.org\/10.1055\/s-0045-1813003","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0102-3616","1982-4378"],"issn-type":[{"value":"0102-3616","type":"print"},{"value":"1982-4378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]}}}