{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:18:31Z","timestamp":1783034311653,"version":"3.54.6"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nucl Med"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>68Ga-DOTATATE positron emission tomography\/computed tomography (PET\/CT) is a more accurate way to distinguish neuroendocrine tumors compared with conventional diagnostic methods and a standard impressive way to evaluate disease entities. This is based on 68Ga-DOTATATE affinity to somatostatin receptors that are overexpressed in the majority of neuroendocrine tumors. In this case presentation, it is aimed to demonstrate the role of 68Ga-DOTATATE PET\/CT scan beyond the detection of neuroendocrine tumors.<\/jats:p>\n                  <jats:p>A 59-year-old Iranian male patient with clear cell renal cell carcinoma who underwent nephrectomy 4 years ago has been referred for evaluation of a diagnosed painful abdominal mass by CT. 68Ga-DOTATATE PET\/CT scan showed a large, lobulated border 68Ga-DOTATATE avid retroperitoneal tumoral mass in the region of pancreatic head and uncinate process, with fat plane obliteration with duodenum and inferior vena cava.<\/jats:p>\n                  <jats:p>Conspicuous physiological uptake has been reported in the pancreatic head in 16 to 70% of 68Ga-DOTATATE. Pathological results and immunohistochemistry evaluations confirmed the renal cell carcinoma based on metastases; so, the suspicious diagnosis of neuroendocrine tumor was ruled out.<\/jats:p>\n                  <jats:p>Malignancies, a part of neuroendocrine tumors, may express somatostatin receptors and 68Ga-DOTATATE or other octreotide derivatives based radiopharmaceuticals uptake appears.<\/jats:p>","DOI":"10.1055\/s-0045-1813681","type":"journal-article","created":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T23:30:17Z","timestamp":1763940617000},"page":"164-167","source":"Crossref","is-referenced-by-count":0,"title":["Incidental 68Ga -DOTATATE Uptake in Metastatic Clear Cell Renal Cell Carcinoma: A Case Report"],"prefix":"10.1055","volume":"25","author":[{"given":"Fatemeh","family":"Saboktakin","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Tehran University of Medical Sciences, Vali-Asr Hospital, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Farzanehfar","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Tehran University of Medical Sciences, Vali-Asr Hospital, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Vahidfar","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Tehran University of Medical Sciences, Vali-Asr Hospital, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloofar","family":"Tabatabaeian","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Tehran University of Medical Sciences, Vali-Asr Hospital, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,11,23]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"e7237","DOI":"10.1002\/cam4.7237","article-title":"Renal cell carcinoma and risk of second primary cancer: a Danish nationwide cohort study","volume":"13","author":"M B Bengtsen","year":"2024","journal-title":"Cancer Med"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"17009","DOI":"10.1038\/nrdp.2017.9","article-title":"Renal cell carcinoma","volume":"3","author":"J J Hsieh","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"25","key":"ref3","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1200\/JCO.22.00868","article-title":"Management of metastatic clear cell renal cell carcinoma: ASCO guideline","volume":"40","author":"W K Rathmell","year":"2022","journal-title":"J Clin Oncol"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"e517","DOI":"10.1016\/j.clgc.2018.03.011","article-title":"Somatostatin receptor expression in renal cell carcinoma\u2014a new front in the diagnostics and treatment of renal cell carcinoma","volume":"16","author":"A H\u00f6\u00f6g","year":"2018","journal-title":"Clin Genitourin Cancer"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1097\/RLU.0000000000003775","article-title":"Solitary contralateral adrenal metastasis of renal cell carcinoma: 68Ga-DOTATATE PET\/CT findings","volume":"47","author":"N Filizoglu","year":"2022","journal-title":"Clin Nucl Med"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1267\/ahc.14024","article-title":"Expressions of somatostatin receptor subtypes (SSTR-1, 2, 3, 4 and 5) in neuroblastic tumors; special reference to clinicopathological correlations with international neuroblastoma pathology classification and outcomes","volume":"47","author":"N Watanabe","year":"2014","journal-title":"Acta Histochem Cytochem"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2967\/jnumed.117.202275","article-title":"Appropriate use criteria for somatostatin receptor PET imaging in neuroendocrine tumors","volume":"59","author":"T A Hope","year":"2018","journal-title":"J Nucl Med"},{"issue":"05","key":"ref8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s13139-022-00761-7","article-title":"68Ga-DOTATATE avid metastatic vertebral renal cell carcinoma in the setting of von Hippel-Lindau syndrome","volume":"56","author":"M Patel","year":"2022","journal-title":"Nucl Med Mol Imaging"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/RLU.0000000000001887","article-title":"68Ga-DOTATATE uptake in a soft tissue metastasis from clear cell renal cell cancer","volume":"43","author":"S Vamadevan","year":"2018","journal-title":"Clin Nucl Med"},{"issue":"01","key":"ref10","first-page":"57","article-title":"False positive 68Ga-DOTA-NOC: role for endoscopic ultrasound assessment. Revista Portuguesa de Endocrinologia","volume":"11","author":"L R Ramos","year":"2016","journal-title":"Diabetes Metab"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1097\/RLU.0b013e31825b2555","article-title":"Semiquantitative analysis and characterization of physiological biodistribution of (68)Ga-DOTA-TATE PET\/CT","volume":"37","author":"J Kunikowska","year":"2012","journal-title":"Clin Nucl Med"},{"issue":"01","key":"ref12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/RLU.0b013e3182393404","article-title":"Ga-68 DOTA-NOC uptake in the pancreas: pathological and physiological patterns","volume":"37","author":"Y Krausz","year":"2012","journal-title":"Clin Nucl Med"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/RLU.0000000000001431","article-title":"Physiological uptake in the pancreatic head on somatostatin receptor scintigraphy using [111In-DTPA] octreotide: incidence and mechanism","volume":"42","author":"T Brabander","year":"2017","journal-title":"Clin Nucl Med"},{"issue":"04","key":"ref14","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s00259-012-2309-3","article-title":"68Ga-DOTA-TOC uptake in neuroendocrine tumour and healthy tissue: differentiation of physiological uptake and pathological processes in PET\/CT","volume":"40","author":"A Kroiss","year":"2013","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"09","key":"ref15","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1097\/MNM.0000000000000710","article-title":"Uptake in the pancreatic uncinate process on the 111In-octreotide scintigraphy: how to distinguish physiological from pathological uptake?","volume":"38","author":"A Ait Boudaoud","year":"2017","journal-title":"Nucl Med Commun"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1097\/RLU.0000000000002718","article-title":"68Ga-DOTATATE uptake in pancreatic metastasis of renal cell carcinoma mimicking pancreatic neuroendocrine tumor","volume":"44","author":"C Soydal","year":"2019","journal-title":"Clin Nucl Med"},{"issue":"22","key":"ref17","doi-asserted-by":"crossref","first-page":"e20197","DOI":"10.1097\/MD.0000000000020197","article-title":"Incidental 68Ga-DOTATATE uptake in the pancreatic head: a case report and a unique opportunity to improve clinical care","volume":"99","author":"R Lakhotia","year":"2020","journal-title":"Medicine (Baltimore)"}],"container-title":["World Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0045-1813681.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:37:56Z","timestamp":1783031876000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0045-1813681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,23]]},"references-count":17,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2026,7,2]]},"published-print":{"date-parts":[[2026,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0045-1813681","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1450-1147","1607-3312"],"issn-type":[{"value":"1450-1147","type":"print"},{"value":"1607-3312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,23]]}}}