{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T23:52:28Z","timestamp":1767052348607,"version":"3.48.0"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":89,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Avicenna J Med"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cancer is a global health challenge, with millions of new cases annually. While improving survival rates, the disease and its treatment, particularly chemotherapy, significantly impact patients' quality of life (QoL) and cause side effects that severely affect patients' physical, emotional, and social well-being. As the number of cancer patients is rising in Pakistan, the health care system still faces multiple issues that may have an impact on patient outcomes and QoL. So, this study aims to assess the QoL of cancer patients before and after chemotherapy at a tertiary care hospital in Islamabad.<\/jats:p>\n                  <jats:p>A prospective cohort study at PIMS, Islamabad, enrolled 184 chemotherapy patients using consecutive sampling techniques. Ethical approvals and informed consent were obtained. Clinical as well as demographic data, together with well-being (Functional Assessment of Cancer Therapy\u2013General [FACT-G]), were analyzed using SPSS version 21.<\/jats:p>\n                  <jats:p>Of 184 patients, 71.9% had hematological malignancies and 28.1% solid tumors. FACT-G scores demonstrated significant domain-specific improvements following chemotherapy, in which physical and functional well-being improved significantly (p\u2009=\u20090.008 and 0.01, respectively), while emotional and social well-being showed modest but nonsignificant changes. Additionally, marked improvements were noted in hematological, renal, and hepatic parameters that directly influence the health-related QoL.<\/jats:p>\n                  <jats:p>Chemotherapy significantly improved QoL in specific domains, particularly physical and functional well-being, though emotional and social challenges persisted. These findings highlight the need for early detection, comprehensive supportive care, and survivorship programs tailored to the Pakistani context in mitigating these impacts and enhancing patient well-being.<\/jats:p>","DOI":"10.1055\/s-0045-1814102","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T23:48:08Z","timestamp":1767052088000},"page":"157-164","source":"Crossref","is-referenced-by-count":0,"title":["Chemotherapy and Quality of Life: An Observational Study of Cancer Patients at the Oncology Unit of Tertiary Care Hospital in Islamabad"],"prefix":"10.1055","volume":"15","author":[{"given":"Sameen","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanza","family":"Zahid","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilal","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Asim","family":"Ali","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8158-5908","authenticated-orcid":false,"given":"Muhammad Nouman","family":"Asghar","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amna","family":"Shahid","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kainat","family":"Hameed","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"e2339116","DOI":"10.1001\/jamanetworkopen.2023.39116","article-title":"Chemotherapy-related toxic effects and quality of life and physical functioning in older patients","volume":"6","author":"J C Baltussen","year":"2023","journal-title":"JAMA Netw Open"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.3390\/ijerph18042023","article-title":"Key factors associated with adherence to physical exercise in patients with chronic diseases and older adults: an umbrella review","volume":"18","author":"D 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The Determinants of Health of Populations","author":"R G Evans","year":"2021"},{"issue":"06","key":"ref13","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.eururo.2017.06.035","article-title":"Quality of life outcomes after primary treatment for clinically localised prostate cancer: a systematic review","volume":"72","author":"M Lardas","year":"2017","journal-title":"Eur Urol"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"E54","DOI":"10.1097\/NCC.0000000000000689","article-title":"Changes in fatigue, psychological distress, and quality of life after chemotherapy in women with breast cancer: a prospective study","volume":"43","author":"P J Oh","year":"2020","journal-title":"Cancer Nurs"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1001\/jamasurg.2020.3325","article-title":"Association of breast cancer surgery with quality of life and psychosocial well-being in young breast cancer survivors","volume":"155","author":"S M Rosenberg","year":"2020","journal-title":"JAMA Surg"},{"issue":"23","key":"ref16","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1002\/cncr.30912","article-title":"The relationship between physical and psychological symptoms and health care utilization in hospitalized patients with advanced cancer","volume":"123","author":"R D Nipp","year":"2017","journal-title":"Cancer"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1201\/9781003068648-3","volume-title":"Measuring the effect of cancer on quality of life","author":"D Osoba","year":"2021"},{"issue":"04","key":"ref18","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s12276-022-00752-w","article-title":"Understanding the molecular basis of anorexia and tissue wasting in cancer cachexia","volume":"54","author":"E Yeom","year":"2022","journal-title":"Exp Mol Med"},{"issue":"03","key":"ref19","doi-asserted-by":"crossref","first-page":"e200363","DOI":"10.1001\/jamanetworkopen.2020.0363","article-title":"Patient experience captured by quality-of-life measurement in oncology clinical trials","volume":"3","author":"A Haslam","year":"2020","journal-title":"JAMA Netw Open"}],"container-title":["Avicenna Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0045-1814102.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T23:48:15Z","timestamp":1767052095000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0045-1814102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":19,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2025,12,29]]},"published-print":{"date-parts":[[2025,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0045-1814102","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2231-0770","2249-4464"],"issn-type":[{"value":"2231-0770","type":"print"},{"value":"2249-4464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]}}}