{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:47:43Z","timestamp":1790423263387,"version":"4.1.0"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aging is accompanied by an increasing incidence of dementia. Alzheimer's disease (AD) is the leading cause of dementia, and it impairs autonomic function. Heart rate variability (HRV) is a marker of autonomic function, but findings in AD are conflicting, and there is scant information on the association of HRV with falls in dementia patients.<\/jats:p>\n                  <jats:p>To assess autonomic activity in older adults with AD, comparing these patients to older adults without dementia (the control group, CG), and to investigate the relationship between HRV and falls.<\/jats:p>\n                  <jats:p>The HRV was analyzed in older adults without dementia and in those with AD using a heart rate monitor. The measurements were made on a single day in the supine and orthostatic positions for 10\u2009minutes each. The HRV components in the time and frequency domains were assessed, along with the history of falls in the past 3 years.<\/jats:p>\n                  <jats:p>The groups were homogenous, with a predominance of female individuals, and mean ages of 81 (AD) and 79 (CG) years. A reduction in the R-R interval upon changing from the supine to the orthostatic positions was evident in both groups, but the AD group showed reduced parasympathetic components in the orthostatic position. For the frequency domain, a reduction in high frequency (HF) and increases in low frequency (LF) and in the LF\/HF ratio were observed, suggesting increased sympathetic and reduced parasympathetic activities. The AD group presented more falls, whose incidence was associated with HRV components.<\/jats:p>\n                  <jats:p>Alzheimer's disease was associated with worse autonomic dysfunction, increased sympathetic activity and greater parasympathetic impairment, a high incidence of falls and interaction with HRV components.<\/jats:p>","DOI":"10.1055\/s-0045-1814401","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T23:30:22Z","timestamp":1769383822000},"page":"001-008","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of heart rate variability and occurrence of falls in Alzheimer's disease: an exploratory study"],"prefix":"10.1055","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4694-7089","authenticated-orcid":false,"given":"Evelize Antunes","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3302-2954","authenticated-orcid":false,"given":"Aline Roberta","family":"Danaga","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alfenas, Alfenas MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5765-7228","authenticated-orcid":false,"given":"Etiene Farah Teixeira de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade Nove de Julho, S\u00e3o Paulo SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6271-3925","authenticated-orcid":false,"given":"Carlos Alberto","family":"Santos Filho","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio de Adamantina, Adamantina SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8729-669X","authenticated-orcid":false,"given":"Jos\u00e9 Burgos","family":"Ponce","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio de Adamantina, Adamantina SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1977-5880","authenticated-orcid":false,"given":"Alessandro Ferrari","family":"Jacinto","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio de Adamantina, Adamantina SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,1,25]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1590\/S1516-44462005000100017","article-title":"[Decline of cognitive capacity during aging]","volume":"27","author":"H C Fichman","year":"2005","journal-title":"Rev Bras Psiquiatr"},{"key":"ref2","volume-title":"Dem\u00eancia do Idoso: Diagn\u00f3stico na Aten\u00e7\u00e3o Prim\u00e1ria \u00e0 Sa\u00fade","author":"Sociedade Brasileira de Medicina de Fam\u00edlia e Comunidade, Academia Brasileira de Neurologia","year":"2009"},{"issue":"03","key":"ref3","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1590\/S1980-57642011DN05030002","article-title":"Criteria for the diagnosis of Alzheimer's disease: Recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology","volume":"5","author":"N AF Frota","year":"2011","journal-title":"Dement Neuropsychol"},{"issue":"S 01","key":"ref4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1590\/S1516-44462002000500003","article-title":"Como diagnosticar as quatro causas mais frequentes de dem\u00eancia?","volume":"24","author":"P Caramelli","year":"2002","journal-title":"Rev Bras Psiquiatr"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1159\/000082885","article-title":"Autonomic function assessed by heart rate variability is normal in Alzheimer's disease and vascular dementia","volume":"19","author":"L M Allan","year":"2005","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"03","key":"ref6","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.ncl.2007.03.008","article-title":"Alzheimer's disease and mild cognitive impairment","volume":"25","author":"B J Kelley","year":"2007","journal-title":"Neurol Clin"},{"key":"ref7","volume-title":"World Alzheimer Report 2013. 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