{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:59:38Z","timestamp":1785452378409,"version":"3.56.0"},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Neurosurg"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cholesterol granuloma (CG) is a benign expansile lesion caused by the breakdown of blood products and subsequent granulomatous reaction, most often found in pneumatized bones. Frontal sinus involvement is exceedingly rare, especially in children, and may mimic mucoceles, abscesses, or fungal disease on imaging. We present a 16-year-old male with a painful, progressively enlarging frontal swelling and headache. MRI revealed a lobulated lesion hyperintense on both T1- and T2-weighted sequences with peripheral enhancement, initially suggesting an abscess-like process. CT showed an expansile lytic lesion with erosion of the frontal sinus tables. Due to significant bony destruction, a bicoronal open approach was performed, achieving complete excision and cranioplasty. Histopathology confirmed CG, demonstrating cholesterol clefts, hemosiderin-laden macrophages, and multinucleated giant cells. The postoperative course was uneventful, and no recurrence was observed. This case highlights the diagnostic challenge of frontal sinus CG, particularly in younger patients, and emphasizes the importance of recognizing its radiologic characteristics to avoid misdiagnosis. Early identification and surgical excision are essential to prevent orbital or intracranial complications and achieve favorable clinical outcomes.<\/jats:p>","DOI":"10.1055\/s-0046-1815954","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T23:54:42Z","timestamp":1770422082000},"page":"602-606","source":"Crossref","is-referenced-by-count":0,"title":["Frontal Cholesterol Granuloma in a Pediatric Patient: A Case Report"],"prefix":"10.1055","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7675-3983","authenticated-orcid":false,"given":"Do\u011fu","family":"\u0130lerler","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Adana City Research and Education Hospital, Adana, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2346-9106","authenticated-orcid":false,"given":"Sayg\u0131","family":"Uygur","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kadirli State Hospital, Osmaniye, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0292-201X","authenticated-orcid":false,"given":"Ali \u0130hsan","family":"\u00d6kten","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Adana City Research and Education Hospital, Adana, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12886-023-02842-3","article-title":"Orbitofrontal cholesterol granuloma masquerading as frontal sinus mucoceles: report of two cases","volume":"23","author":"R Li","year":"2023","journal-title":"BMC Ophthalmol"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/sinusitis9020015","article-title":"Cholesterol granuloma of the frontal sinus complicated by mycetoma: a rare case report","volume":"9","author":"C Rustichelli","year":"2025","journal-title":"Sinusitis"},{"key":"ref3","first-page":"X221116711","article-title":"Bilateral cholesterol granulomas of the maxillary sinus with review of the literature","volume":"10","author":"N Wershoven","year":"2022","journal-title":"SAGE Open Med Case Rep"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.wneu.2015.11.095","article-title":"Orbitofrontal cholesterol granuloma: four case reports and a systematic review of the English literature","volume":"87","author":"J D Hughes","year":"2016","journal-title":"World Neurosurg"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1007\/s12070-024-04712-w","article-title":"A novel case of paediatric petrous apex cholesterol granuloma","volume":"76","author":"R Naga","year":"2024","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4103\/jomr.jomr_19_18","article-title":"An unexpected finding in the frontal sinus: cholesterol granuloma","volume":"6","author":"L L Wuyts","year":"2018","journal-title":"J Oral Maxillofac Radiol"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/0145561318823419","article-title":"Endoscopic view of cholesterol granuloma of the maxillary sinus","volume":"98","author":"J-H Lee","year":"2019","journal-title":"Ear Nose Throat J"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/alr.21093","article-title":"Paranasal sinus cholesterol granuloma: systematic review of diagnostic and management aspects","volume":"3","author":"A Durgam","year":"2013","journal-title":"Int Forum Allergy Rhinol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.25259\/SNI_316_2023","article-title":"Transglabellar resection of frontal sinus cholesterol granuloma extending cranially through cecum foramina: Technical note","volume":"14","author":"A Al-Mousa","year":"2023","journal-title":"Surg Neurol Int"}],"container-title":["Asian Journal of Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0046-1815954.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:39:41Z","timestamp":1785451181000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0046-1815954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,6]]},"references-count":9,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,7,30]]},"published-print":{"date-parts":[[2026,9]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0046-1815954","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1793-5482","2248-9614"],"issn-type":[{"value":"1793-5482","type":"print"},{"value":"2248-9614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,6]]}}}