{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T23:47:39Z","timestamp":1782431259368,"version":"3.54.5"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Myasthenia gravis is an antibody-mediated disorder of the neuromuscular junction. Fatigability and fluctuations are hallmarks of the disease, posing a challenge: evaluation through a single physical examination may not reflect disease control. A shift towards patient-reported Outcomes is a new paradigm in the current practice, and these outcomes are usually assessed through validated scales. In the present paper, we discuss some of the most used scales in the clinical practice, such as the Myasthenia Gravis Foundation of America (MGFA) scale, the Myasthenia Gravis Activities of Daily Living (MG-ADL) scale, and the 15-Item Myasthenia Gravis Quality of Life (MG-QOL15) scale. Definitions of remission, minimal manifestation, high-burden disease, highly-active disease, and others are reviewed, and correlations involving these definitions and the scales are presented. Guidance on how to assess disease severity, therapeutic response, and a rationale for treatment escalation are explored.<\/jats:p>","DOI":"10.1055\/s-0046-1817031","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T23:41:58Z","timestamp":1782430918000},"page":"001-005","source":"Crossref","is-referenced-by-count":0,"title":["Optimizing myasthenia gravis management in practice: integrating clinical scales and classification systems"],"prefix":"10.1055","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2708-1181","authenticated-orcid":false,"given":"Jos\u00e9 Pedro Soares","family":"Baima","sequence":"additional","affiliation":[{"name":"Hospital Geral de Fortaleza, Servi\u00e7o de Neurologia, Fortaleza CE, Brazil."},{"name":"Universidade Federal do Cear\u00e1, Hospital Universit\u00e1rio Walter Cant\u00eddio, Fortaleza CE, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7568-0897","authenticated-orcid":false,"given":"Caio C\u00e9sar Diniz","family":"Disserol","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Hospital de Cl\u00ednicas, Curitiba PR, Brazil."},{"name":"Instituto de Neurologia de Curitiba, Curitiba PR, Brazil."},{"name":"Hospital Israelita Albert Einstein, Instituto do C\u00e9rebro, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5459-9253","authenticated-orcid":false,"given":"Eduardo Braga de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Hospital Geral de Fortaleza, Servi\u00e7o de Neurologia, Fortaleza CE, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7454-1526","authenticated-orcid":false,"given":"Nat\u00e1lia Merten","family":"Athayde","sequence":"additional","affiliation":[{"name":"Hospital Geral de Fortaleza, Servi\u00e7o de Neurologia, Fortaleza CE, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6070-1808","authenticated-orcid":false,"given":"Lara Albuquerque de","family":"Brito","sequence":"additional","affiliation":[{"name":"Hospital Geral de Fortaleza, Servi\u00e7o de Neurologia, Fortaleza CE, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5408-4399","authenticated-orcid":false,"given":"Hermany Capistrano","family":"Freitas","sequence":"additional","affiliation":[{"name":"Hospital Geral de Fortaleza, Servi\u00e7o de Neurologia, Fortaleza CE, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0063-8971","authenticated-orcid":false,"given":"Cleonisio Leite","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Hospital Geral de Fortaleza, Servi\u00e7o de Neurologia, Fortaleza CE, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1590\/0004-282X-ANP-2022-S105","article-title":"Myasthenia gravis in clinical practice","volume":"80","author":"E P Estephan","year":"2022","journal-title":"Arq Neuro-Psiquiatr"},{"issue":"07","key":"ref2","doi-asserted-by":"publisher","first-page":"e16280","DOI":"10.1111\/ene.16280","article-title":"Expert consensus recommendations for improving and standardising the assessment of patients with generalised myasthenia gravis","volume":"31","author":"A Meisel","year":"2024","journal-title":"Eur J 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