{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:18:07Z","timestamp":1783034287352,"version":"3.54.6"},"reference-count":47,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nucl Med"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Congenital anomalies of the kidney and urinary tract (CAKUT) result from embryonic developmental defects and are usually not isolated. We evaluate the functional status of the kidney with Tc-99m renal scintigraphy in CAKUT patients associated with a rare complex systemic syndrome\/sequence.<\/jats:p>\n                  <jats:p>We retrospectively screened 788 Tc-99m EC (ethylenedicysteine) and 187 Tc-99m DMSA (dimercaptosuccinic acid) renal scintigraphies performed between January 2022 and November 2024. Patients were selected based on the presence of congenital systemic syndrome and CAKUT.<\/jats:p>\n                  <jats:p>The Kruskal\u2013Wallis test was used to compare grading of functional impairment of kidneys across different systemic syndromes. The Mann\u2013Whitney U-test was used to compare the functional impairment of the kidney for continuous variables.<\/jats:p>\n                  <jats:p>A total of 38 patients (23 males, 15 females, mean age: 6.7\u2009\u00b1\u20096.7, range 0.03\u201333 years) of congenital systemic syndrome with associated CAKUT were identified. The most common systemic syndrome was anorectal malformation in 15 patients (39.5%). A few patients had features of more than one syndrome. The most common CAKUT was an orthotopic or ectopic nonfunctioning kidney in 15 patients (39.5%). The Tc-99m renal scintigraphies showed abnormal findings in 31 patients and normal findings in 7 patients. The proportion of abnormal findings was 81.6% (95% confidence interval: 65.7\u201392.3%). The difference in proportion of abnormal findings of renal scintigraphy across different syndromes was not statistically significant (Fisher's exact test, p\u2009=\u20090.128). The Kruskal\u2013Wallis H-test revealed significant differences in the grading of functional impairment of kidneys across different systemic syndromes, H(16)\u2009=\u200927.24, p\u2009=\u20090.039. The Mann\u2013Whitney U-test revealed significant difference (p\u2009=\u20090.007) in serum creatinine of normal Tc-99m scintigraphy (mean\u2009=\u20090.49, n\u2009=\u20097) and abnormal Tc-99m scintigraphy (mean =1.25, n\u2009=\u200931), U\u2009=\u200936.5, z\u2009=\u20092.71, r\u2009=\u20091.65. However, there was no significant difference (p\u2009=\u20090.097) in the age of patients who showed normal and abnormal Tc-99m scintigraphies.<\/jats:p>\n                  <jats:p>A complex systemic syndrome may have occult CAKUT that remains silent initially but presents as a complicated case later. Thus, these patients need functional evaluation with Tc-99m EC and Tc-99m DMSA scintigraphies for early diagnosis of renal anomaly and timely management and follow-up, especially after surgical intervention, to avoid future complications.<\/jats:p>","DOI":"10.1055\/s-0046-1820100","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:05:52Z","timestamp":1776380752000},"page":"136-148","source":"Crossref","is-referenced-by-count":0,"title":["Tc-99m Renal Scintigraphy in Complex Congenital Systemic Syndromes Associated with Congenital Anomalies of the Kidney and Urinary Tract: A Retrospective Single-Center Study"],"prefix":"10.1055","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8784-5572","authenticated-orcid":false,"given":"Deepa","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suruchi","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.2215\/CJN.12581019","article-title":"A primer on congenital anomalies of the kidneys and urinary tracts (CAKUT)","volume":"15","author":"V Murugapoopathy","year":"2020","journal-title":"Clin J Am Soc 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