{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:49:25Z","timestamp":1791589765844,"version":"4.3.4"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Neurosurg"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that primarily affects the colon. Among its extraintestinal complications, cerebral venous sinus thrombosis (CVST) is a rare yet potentially life-threatening emergency that can manifest as headaches, seizures, and\/or neurological deficits. This review aims to characterize the clinical presentation, diagnostic modalities, and management strategies for CVST in UC patients. A comprehensive search of case reports and series yielded 1,156 studies, of which 39 met the inclusion criteria. A total of 47 patients were identified; the majority of whom were adult males (33.3%) and commonly presented with headaches (67.4%). Multi-symptom presentations were more prevalent in adults (66%; p\u2009=\u20090.038) and were often associated with UC flare-ups (56.4%). Patients with multiple symptoms had a higher frequency of straight and sphenoid sinus involvement compared with those with an isolated symptom (p\u2009&lt;\u20090.001). Anemia was correlated with poorer clinical outcomes (p\u2009=\u20090.009). Computed tomography (CT) was the most frequently used initial imaging modality, whereas magnetic resonance imaging (MRI) was more sensitive. Anticoagulation therapy with low-molecular-weight heparin and warfarin, alongside endovascular thrombectomy in select cases, was effective in improving outcomes. This review underscores the importance of early recognition, MRI-based imaging, and timely anticoagulation to improve outcomes in UC-associated CVST.<\/jats:p>","DOI":"10.1055\/s-0046-1820445","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T23:04:06Z","timestamp":1777071846000},"page":"658-665","source":"Crossref","is-referenced-by-count":0,"title":["Unraveling the Clinical Puzzle of Cerebral Venous Sinus Thrombosis in Ulcerative Colitis: Insights from a Systematic Review"],"prefix":"10.1055","volume":"21","author":[{"given":"Sadeen","family":"Eid","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan"},{"name":"Jordan University Hospital, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza K.","family":"Alsalhi","sequence":"additional","affiliation":[{"name":"Jordan University Hospital, Amman, Jordan"},{"name":"Faculty of Medicine, Hashemite University, Zarqa, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeid","family":"Qudeimat","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S.","family":"Alhallaq","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Mansoura University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Idrees","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Lahore General Hospital, Lahore, Punjab, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusra","family":"Arafeh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirajeddin","family":"Belkhair","sequence":"additional","affiliation":[{"name":"Neurosciences Department, Qatar University, Doha, Qatar"},{"name":"Neurosciences Department, DOC Medical Center, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0889-8553(01)00002-4","article-title":"Epidemiology of inflammatory bowel disease","volume":"31","author":"E V Loftus Jr","year":"2002","journal-title":"Gastroenterol Clin North Am"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/j.1572-0241.2006.00381.x","article-title":"A population-based case control study of potential risk factors for IBD","volume":"101","author":"C N Bernstein","year":"2006","journal-title":"Am J 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