{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:49:38Z","timestamp":1791589778399,"version":"4.3.4"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Neurosurg"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To evaluate the association of the SOX17 gene with intracranial aneurysm (IA) and its expression in a patient with IA.<\/jats:p>\n                  <jats:p>Patients visiting the Department of Neurosurgery from March 2020 to December 2021 were screened for IA on the basis of clinical criteria of sudden-onset headache, loss of consciousness, etc. The diagnosis of subarachnoid hemorrhage was made on plain computed tomography (CT; head), and the presence of IA was confirmed by CT angiography brain and\/or on cerebral digital subtraction angiography. Confirmed patients were enrolled in the study after taking informed written consent. A case\u2013control design was used, with 50 IA patients as cases and 50 age- and sex-matched normal individuals from the community who were healthy subjects with no risk factors for IA formation as controls.<\/jats:p>\n                  <jats:p>The 50 patients with IA included 48% females and 52% males, with age ranging from 26 to 78 years (mean age: 50.84\u2009\u00b1\u200912.33 years). The majority (26 patients) of patients were in the age groups of 40 to 60 years, 16 patients were above 60 years, and only 8 cases were below the age of 40 years. The 50 healthy control subjects included 16 females and 34 males, with age ranging from 30 to 67 years (mean age: 51.12\u2009\u00b1\u200910.29 years). Both cases and controls were found to be similar in terms of age distribution (p-value\u2009=\u20090.752) as well as the mean age (p-value\u2009=\u20090.689). The SOX 17 gene mRNA expression in the blood of IA patients was analyzed and compared with the healthy control group. The SOX17 gene mRNA expression was higher in IA patients (2\u2212\u0394C\n                  \n                  T\u2009=\u20090.69) in comparison with the healthy control (2\u2212\u0394C\n                  \n                  T\u2009=\u20090.11). As compared with the healthy control taken as reference, the decrease in SOX17 gene mRNA expression in the blood of IA patients (2\u2212\u0394\u0394C\n                  \n                  T 5.96-fold) was statistically significant (p-value\u2009&lt;\u20090.01).<\/jats:p>\n                  <jats:p>From our study, we conclude that there is a significant positive association between SOX17 gene with IA, hence this gene has been found to be overexpressed. As a result, this may be used as a simple, minimally invasive blood screening tool to assess the risk of IA formation in high-risk group individuals.<\/jats:p>","DOI":"10.1055\/s-0046-1820450","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T22:56:35Z","timestamp":1779490595000},"page":"796-800","source":"Crossref","is-referenced-by-count":0,"title":["SOX17: Insight into the Genesis of Intracranial Aneurysm"],"prefix":"10.1055","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-7453","authenticated-orcid":false,"given":"Bhanu Pratap Singh","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, All India Institute of Medical Sciences, Bilaspur, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Irungbam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Maulana Azad Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4483-1414","authenticated-orcid":false,"given":"Binita","family":"Dholakia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaam","family":"Bodeliwala","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghanshyam Das","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Jagetia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daljit","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niraj","family":"Ghimire","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Govind Ballabh Pant Institute of Postgarduate medical education and research, New delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Bhandari","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Govind Ballabh Pant Institute of Postgarduate medical education and research, New delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"issue":"18","key":"ref1","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1056\/NEJMoa070972","article-title":"Incidental findings on brain MRI in the general population","volume":"357","author":"M W Vernooij","year":"2007","journal-title":"N Engl J Med"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S1474-4422(11)70109-0","article-title":"Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis","volume":"10","author":"M H Vlak","year":"2011","journal-title":"Lancet Neurol"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1038\/ng.240","article-title":"Susceptibility loci for intracranial aneurysm in European and Japanese populations","volume":"40","author":"K Bilguvar","year":"2008","journal-title":"Nat Genet"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1161\/STROKEAHA.112.656397","article-title":"Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk","volume":"43","author":"T Foroud","year":"2012","journal-title":"Stroke"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1002\/humu.21378","article-title":"Mutations in SOX17 are associated with congenital anomalies of the kidney and the urinary tract","volume":"31","author":"S Gimelli","year":"2010","journal-title":"Hum 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