{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:03:06Z","timestamp":1784160186206,"version":"3.55.0"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To evaluate the effects of Mauli banana stem extract (MBSE), used alone or in combination with calcium hydroxide, on DMP-1 expression and dentin bridge thickness following direct pulp capping in rat molars.<\/jats:p>\n                  <jats:p>This study used a post-test control group experimental design involving mechanically exposed maxillary first molars in Wistar rats. Forty male Wistar rats were randomly allocated into eight groups (n\u2009=\u20095 per group), with one maxillary first molar treated in each animal. MBSE (Musa acuminata) was obtained through 70% ethanol maceration, concentrated by rotary evaporation, and prepared as a 50% extract. The exposed molars were treated with propylene glycol (control), calcium hydroxide [Ca(OH)2], 50% MBSE, or a combination of MBSE and Ca(OH)2. The animals were euthanized at 14 and 28 days posttreatment. Dentin matrix protein-1 (DMP-1) expression was assessed by immunohistochemically, and dentin bridge thickness was quantified from hematoxylin\u2013eosin\u2013stained sections using Image Raster software.<\/jats:p>\n                  <jats:p>Data were analyzed using one-way analysis of variance followed by the least significant difference post-hoc test, with significance set at p &lt;0.05.<\/jats:p>\n                  <jats:p>DMP-1 expression increased significantly across all experimental groups at both 14 and 28 days (p\u2009&lt;\u20090.05), with the highest expression observed in the MBSE group at day 28. A time-dependent increase in dentin bridge thickness was also observed, with the MBSE and MBSE\u2009+\u2009Ca(OH)2 groups showing greater thickness than the Ca(OH)2 group. Nevertheless, dentin bridge thickness did not differ significantly between the MBSE and MBSE\u2009+\u2009Ca(OH)2 groups at day 28 (p\u2009&gt;\u20090.05).<\/jats:p>\n                  <jats:p>MBSE, alone and in combination with calcium hydroxide, promoted reparative responses following direct pulp capping. The combination group showed enhanced mineralization-related activity and dentin bridge formation, whereas MBSE alone also demonstrated promising bioactive potential. Additional studies incorporating early inflammatory time points and complementary outcome measures are warranted.<\/jats:p>","DOI":"10.1055\/s-0046-1823639","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:04:55Z","timestamp":1784156695000},"source":"Crossref","is-referenced-by-count":0,"title":["Effects of Mauli Banana Stem Extract, Alone or Combined with Calcium Hydroxide, on DMP-1 Expression and Dentin Bridge Thickness After Direct Pulp Capping in Rat Molars"],"prefix":"10.1055","author":[{"given":"Dewi","family":"Puspitasari","sequence":"additional","affiliation":[{"name":"Doctoral Program, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia"},{"name":"Department of Dental Material, Faculty of Dentistry, Lambung Mangkurat University, Banjarmasin, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ika Kustiyah","family":"Oktaviyanti","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Faculty of Medicine and Health Sciences, Lambung Mangkurat University, Banjarmasin, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maharani Laillyza","family":"Apriasari","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Faculty of Dentistry, Lambung Mangkurat University, Banjarmasin, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erni","family":"Marlina","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tanumihardja","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"issue":"22","key":"ref1","doi-asserted-by":"crossref","first-page":"6811","DOI":"10.3390\/ma14226811","article-title":"Effectiveness of direct pulp capping bioactive materials in dentin regeneration: a review","volume":"14","author":"E Nie","year":"2021","journal-title":"Materials (Basel)"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.joen.2015.03.017","article-title":"Tomographic evaluation of reparative dentin formation after direct pulp capping with Ca(OH)2, MTA, biodentine, and dentin bonding system in human teeth","volume":"41","author":"A Nowicka","year":"2015","journal-title":"J Endod"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.joen.2018.12.002","article-title":"Characterization of odontoblast-like cell phenotype and reparative dentin 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