{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T23:47:31Z","timestamp":1782431251960,"version":"3.54.5"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":85,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ozzy Osbourne, the legendary frontman of Black Sabbath, publicly revealed his diagnosis of Parkinson's disease (PD) in 2020, offering visibility to a complex neurodegenerative condition. His case, later linked to a mutation in the PARK2 (parkin) gene, presented atypically with a later age of onset, contributing to ongoing discussions about the phenotypic variability of genetic forms of PD. Beyond medical narratives, Osbourne's openness and philanthropy\u2014culminating in a benefit concert that raised $190 million for Parkinson's and pediatric charities\u2014played a transformative role in destigmatizing the disease. This article explores the scientific and social impact of Osbourne's disclosure, highlighting the role of PARK2 in mitochondrial homeostasis, synaptic integrity, and tumor suppression. We also examine his pursuit of experimental stem cell therapy, discussing its scientific basis, ethical considerations, and current clinical research landscape.<\/jats:p>","DOI":"10.1055\/s-0046-1823655","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T23:39:04Z","timestamp":1782430744000},"page":"001-004","source":"Crossref","is-referenced-by-count":0,"title":["Ozzy Osbourne and Parkinson's disease: from darkness to awareness"],"prefix":"10.1055","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7522-7801","authenticated-orcid":false,"given":"Luis F. Fabrini","family":"Paleare","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Escola de Medicina, Departamento de Medicina Interna, Curitiba PR, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1672-8894","authenticated-orcid":false,"given":"Jos\u00e9 Luiz","family":"Pedroso","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Departamento de Medicina Interna, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8051-4738","authenticated-orcid":false,"given":"Fl\u00e1via de Paiva Santos","family":"Rolim","sequence":"additional","affiliation":[{"name":"Universidade de Fortaleza, Escola de Medicina, Fortaleza CE, Brazil."},{"name":"Hospital Geral de Fortaleza, Departamento de Neurologia, Fortaleza CE, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8450-8201","authenticated-orcid":false,"given":"Nat\u00e1lia R.","family":"Karpejany","sequence":"additional","affiliation":[{"name":"Universidade Federal do Piau\u00ed, Hospital Universit\u00e1rio, Teresina PI, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3533-0347","authenticated-orcid":false,"given":"Carlos Henrique Ferreira","family":"Camargo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Interna, Disciplina de Doen\u00e7as Neurodegenerativas, Curitiba PR, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2305-1073","authenticated-orcid":false,"given":"H\u00e9lio A. G.","family":"Teive","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Interna, Disciplina de Doen\u00e7as Neurodegenerativas, Curitiba PR, Brazil."},{"name":"Universidade Federal do Paran\u00e1, Departamento de Cl\u00ednica M\u00e9dica, Curitiba PR, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0207-3671","authenticated-orcid":false,"given":"Gustavo L.","family":"Franklin","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Escola de Medicina, Departamento de Medicina Interna, Curitiba PR, Brazil."},{"name":"Universidade Federal do Paran\u00e1, Departamento de Cl\u00ednica M\u00e9dica, Curitiba PR, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S1474-4422(21)00030-2","article-title":"Challenges in the diagnosis of Parkinson's disease","volume":"20","author":"E Tolosa","year":"2021","journal-title":"Lancet Neurol"},{"key":"ref2","first-page":"416","volume-title":"I am Ozzy","author":"O Osbourne","year":"2009"},{"key":"ref3","volume-title":"A-ha Singer Morten Harket Reveals He Has Parkinson's Disease, Says He's Not Sure if He'll Sing Again [Internet]","author":"C Willman"},{"key":"ref4","volume-title":"Ozzy Osbourne Shined a Light on Parkinson's Stigma\u2014By speaking out, 'The Prince of Darkness' lightened the load for others [Internet]","author":"I Subramanian"},{"key":"ref5","volume-title":"Ozzy Osbourne reveals health diagnosis for first time after a year of challenges [Internet]. 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