{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:17:17Z","timestamp":1783127837124,"version":"3.54.6"},"reference-count":45,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":63,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Medication overuse headache (MOH) is a chronic headache (CH) that develops or worsens due to medication overuse. Somatization and hypochondriasis, as well as beliefs about the experienced pain, may accompany many chronic pain situations from a holistic perspective.<\/jats:p>\n                  <jats:p>This study aimed to compare MOH patients with CH and episodic headache (EH) in terms of somatization, hypochondriasis, and beliefs and attitudes on pain.<\/jats:p>\n                  <jats:p>The Hospital Depression and Anxiety Scale (HADS), the Somatosensory Amplification Scale (SSAS), the Pain Beliefs Questionnaire (PBQ), the Pain Catastrophizing Scale (PCS), Eysenck Personality Questionnaire Revised\u2013Short Form (EPQR-S), and Whiteley index-7 (WI-7) were administered to the participants with MOH (n\u2009=\u200980), CH (n\u2009=\u200981), and EH (n\u2009=\u200979).<\/jats:p>\n                  <jats:p>There were no group differences in terms of somatic amplification between MOH and CH group. A high WI_Total score (lower hypochondriacal tendency) was predictive in separating the MOH group from the CH one. The score obtained from the PBQ_Organic subscale in the MOH group was significantly lower than the EH group, while the PCS_Total, PCS_Helplessness, PCS_Rumination, and HADS scores were significantly higher (p\u2009&lt;\u20090.05).<\/jats:p>\n                  <jats:p>Our results indicate that the patients in the MOH group had more organic pain beliefs, felt more helpless in case of pain, and experienced exaggeration and rumination more than the EH group, while hypochondriasis was lower than in the CH group. This could indicate that patients with MOH do not seek further treatment that can lead to more headache medication use without medical examination.<\/jats:p>","DOI":"10.1055\/s-0046-1824430","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:24:30Z","timestamp":1783124670000},"page":"001-011","source":"Crossref","is-referenced-by-count":0,"title":["Hypochondriasis, somatic amplification, and pain beliefs in patients with medication overuse headache"],"prefix":"10.1055","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2859-5072","authenticated-orcid":false,"given":"Zeynep","family":"Ziroglu","sequence":"additional","affiliation":[{"name":"Health Sciences University, Ankara Training and Research Hospital, Department of Neurology, Ankara, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1691-2886","authenticated-orcid":false,"given":"Bur\u00e7in","family":"\u00c7olak","sequence":"additional","affiliation":[{"name":"Ankara University, Faculty of Medicine, Department of Psychiatry, Ankara, Turkey."},{"name":"Ankara University, Brain Research Center, Ankara, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9719-2330","authenticated-orcid":false,"given":"Hafize Nalan","family":"G\u00fcne\u015f","sequence":"additional","affiliation":[{"name":"Health Sciences University, Ankara Training and Research Hospital, Department of Neurology, Ankara, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5662-8266","authenticated-orcid":false,"given":"\u015eeval","family":"Ozayd\u0131nl\u0131","sequence":"additional","affiliation":[{"name":"Health Sciences University, Ankara Training and Research Hospital, Department of Neurology, Ankara, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2441-0624","authenticated-orcid":false,"given":"Levent Ertu\u011frul","family":"\u0130nan","sequence":"additional","affiliation":[{"name":"Health Sciences University, Ankara Training and Research Hospital, Department of Neurology, Ankara, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1055\/s-0030-1249220","article-title":"The epidemiology of primary headache disorders","volume":"30","author":"M S Robbins","year":"2010","journal-title":"Semin Neurol"},{"issue":"02","key":"ref2","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/j.1468-2982.2009.01906.x","article-title":"Prevalence of chronic migraine and medication overuse headache in Germany\u2014the German DMKG headache study","volume":"30","author":"A Straube","year":"2010","journal-title":"Cephalalgia"},{"issue":"07","key":"ref3","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1111\/j.1468-2982.2008.01577.x","article-title":"Prevalence of secondary chronic headaches in a population-based sample of 30\u201344-year-old persons. 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Silva","year":"2014","journal-title":"Headache"},{"issue":"03","key":"ref17","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.ejpain.2004.07.006","article-title":"Psychiatric comorbidity in medication overuse headache patients with pre-existing headache type of episodic tension-type headache","volume":"9","author":"H T Atasoy","year":"2005","journal-title":"Eur J Pain"},{"issue":"07","key":"ref18","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1111\/j.1526-4610.2007.00999.x","article-title":"Behavioral dependence in patients with medication overuse headache: a cross-sectional study in consulting patients using the DSM-IV criteria","volume":"48","author":"F Radat","year":"2008","journal-title":"Headache"},{"issue":"07","key":"ref19","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1136\/jnnp.2008.168864","article-title":"The Severity of Dependence Scale detects people with medication overuse: the Akershus study of chronic headache","volume":"80","author":"R B Grande","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"03","key":"ref20","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/0304-3959(92)90209-T","article-title":"The Pain Beliefs Questionnaire: an investigation of beliefs in the causes and consequences of pain","volume":"51","author":"L C Edwards","year":"1992","journal-title":"Pain"},{"issue":"04","key":"ref21","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1037\/1040-3590.7.4.524","article-title":"The Pain Catastrophizing Scale: Development and validation","volume":"7","author":"M JL Sullivan","year":"1995","journal-title":"Psychol Assess"},{"issue":"01","key":"ref22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/0333102417738202","article-title":"Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition","volume":"38","year":"2018","journal-title":"Cephalalgia"},{"issue":"06","key":"ref23","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"A S Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"issue":"04","key":"ref24","first-page":"280","article-title":"Hastane Anksiyete ve Depresyon \u00d6l\u00e7e\u011fi T\u00fcrk\u00e7e formunun ge\u00e7erlilik ve g\u00fcvenilirli\u011fi","volume":"8","author":"\u00d6 Aydemir","year":"1997","journal-title":"Turk Psikiyatri Derg"},{"issue":"04","key":"ref25","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/0022-3956(90)90004-a","article-title":"The somatosensory amplification scale and its relationship to hypochondriasis","volume":"24","author":"A J Barsky","year":"1990","journal-title":"J Psychiatr 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