{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:00:17Z","timestamp":1790290817314,"version":"4.1.0"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nucl Med"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to assess the diagnostic performance of diuretic-enhanced dual-phase F-18 FDG PET\/CT in detecting muscle invasion in bladder cancer (BC) and to evaluate the predictive role of metabolic and volumetric PET parameters.<\/jats:p>\n                  <jats:p>A total of 105 patients (85 males, 20 females; mean age: 67.8 years) with suspected BC underwent F-18 FDG PET\/CT for initial staging. Routine and delayed pelvic imaging was performed after intravenous furosemide. Metabolic and volumetric parameters, including SUVmax, SUVmean, metabolic tumor volume (MTV), and total lesion glycolysis (TLG), were measured and correlated with histopathological findings. Statistical analyses consisted of Mann\u2013Whitney U, Kruskal\u2013Wallis, and Receiver operating characteristic (ROC) curve analysis.<\/jats:p>\n                  <jats:p>Distant metastases were detected in 30 patients (28.5%), which directly influenced treatment decisions. In the TUR-B cohort (n\u2009=\u200975), F-18 FDG PET\/CT demonstrated a sensitivity of 78.0%, specificity of 62.5%, positive predictive value of 88.5%, negative predictive value of 43.5%, and an overall accuracy of 74.7% in differentiating malignant from benign bladder lesions. Among the 59 patients with confirmed malignancy, volumetric parameters correlated with pathological T-stage. Patients with T2 tumors had significantly higher SUVmax, SUVmean, MTV, and TLG values compared with &lt;T2 tumors (p\u2009&lt;\u20090.001). ROC analysis confirmed the discriminative value of MTV (AUC: 0.814) and TLG (AUC: 0.830), with reliable cutoff values identified.<\/jats:p>\n                  <jats:p>Diuretic-enhanced dual-phase F-18 FDG PET\/CT provides clinically valuable information for the assessment of detrusor muscle invasion and the differentiation of bladder lesions. Quantitative volumetric and metabolic parameters may serve as surrogate biomarkers, supporting preoperative staging and contributing to more precise, personalized treatment strategies for patients with BC.<\/jats:p>","DOI":"10.1055\/s-0046-1824462","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:07:07Z","timestamp":1781737627000},"page":"242-249","source":"Crossref","is-referenced-by-count":0,"title":["Diuretic-Enhanced Dual-Phase F-18 FDG PET\/CT: A New Window Into Muscle-Invasive Bladder Cancer"],"prefix":"10.1055","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5293-6407","authenticated-orcid":false,"given":"Cihan","family":"\u015ein","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Health Sciences, Ba\u011fc\u0131lar Training and Research Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcu","family":"Esen Akka\u015f","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zge","family":"Vural Topuz","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Ac\u0131badem Mehmet Ali Ayd\u0131nlar University, Ac\u0131badem Maslak Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zg\u00fcr","family":"Omak","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hatay Training and Research Hospital, Antakya, Hatay, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enes M.","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harun","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beg\u00fcm","family":"\u00c7al\u0131m G\u00fcrb\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil L.","family":"Canat","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmuttalip","family":"\u015eim\u015fek","sequence":"additional","affiliation":[{"name":"Department of Urology, Memorial Bah\u00e7elievler Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryem","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Health Sciences, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"issue":"03","key":"ref1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"H Sung","year":"2021","journal-title":"CA Cancer J 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