{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:50:09Z","timestamp":1791366609173,"version":"4.3.1"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":57,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ortop (Sao Paulo)"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Resumo<\/jats:title>\n                  <jats:p>Verificar a associa\u00e7\u00e3o entre a presen\u00e7a de conflito de interesses e resultados pr\u00f3-financiadores em ensaios cl\u00ednicos randomizados (ECRs) de cirurgia da m\u00e3o. Como objetivo secund\u00e1rio, avaliar a influ\u00eancia do financiamento da ind\u00fastria sobre os dados bibliom\u00e9tricos desses ECRs.<\/jats:p>\n                  <jats:p>Examinamos 178 ECRs publicados entre 2013 e 2023 em 5 peri\u00f3dicos de alto impacto com foco na m\u00e3o, punho, cotovelo ou nervos perif\u00e9ricos, nas bases de dados MEDLINE, Embase e Scopus. Dos estudos inclu\u00eddos, avaliamos a presen\u00e7a de conflito de interesses declarado e analisamos sua associa\u00e7\u00e3o com o desfecho prim\u00e1rio (favor\u00e1vel vs. n\u00e3o favor\u00e1vel). Avaliamos adicionalmente a associa\u00e7\u00e3o com outras vari\u00e1veis, incluindo conformidade com as diretrizes dos Padr\u00f5es Consolidados de Relat\u00f3rios de Ensaios (CONSORT, do ingl\u00eas Consolidated Standards of Reporting Trials), n\u00famero de autores e fator de impacto dos peri\u00f3dicos. O risco de vi\u00e9s dos estudos inclu\u00eddos foi avaliado utilizando a ferramenta Risk of Bias 2 (RoB 2). Todas as avalia\u00e7\u00f5es foram realizadas por dois revisores independentes, seguindo protocolo previamente definido. Esta revis\u00e3o sistem\u00e1tica n\u00e3o foi previamente registrada em plataformas p\u00fablicas, como a International Prospective Register of Systematic Reviews (PROSPERO).<\/jats:p>\n                  <jats:p>N\u00e3o encontramos rela\u00e7\u00e3o entre presen\u00e7a de conflito de interesses e resultados pr\u00f3-financiadores (35,4% vs. 65,6%; p\u2009=\u20090,503). Estudos financiados pela ind\u00fastria foram publicados em peri\u00f3dicos com fatores de impacto significativamente maiores do que estudos n\u00e3o financiados pela ind\u00fastria (3,05 vs. 2,2) (p\u2009&lt;\u20090,001), com diferen\u00e7a significativa no n\u00famero de autores financiados (1,84 vs. 0,07) (p\u2009&lt;\u20090,001).<\/jats:p>\n                  <jats:p>N\u00e3o foi observada associa\u00e7\u00e3o significativa entre o tipo de financiamento e a obten\u00e7\u00e3o de resultados favor\u00e1veis em ensaios cl\u00ednicos randomizados na cirurgia da m\u00e3o. Estudos financiados foram mais frequentemente publicados em peri\u00f3dicos de maior impacto e apresentaram maior ades\u00e3o ao checklist CONSORT, mas essas caracter\u00edsticas n\u00e3o se traduziram em maior risco de vi\u00e9s.<\/jats:p>","DOI":"10.1055\/s-0046-1824733","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:05:48Z","timestamp":1785279948000},"page":"001-009","source":"Crossref","is-referenced-by-count":0,"title":["Conflito de interesses e influ\u00eancia da ind\u00fastria nos ensaios cl\u00ednicos randomizados na cirurgia da m\u00e3o: uma revis\u00e3o sistem\u00e1tica"],"prefix":"10.1055","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2777-3874","authenticated-orcid":false,"given":"Gabriel Henrique dos Santos","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia e Traumatologia, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4677-1874","authenticated-orcid":false,"given":"Ramon Sampaio Souza","family":"Santos","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia e Traumatologia, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1901-9820","authenticated-orcid":false,"given":"Lu\u00eds Renato","family":"Nakachima","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia e Traumatologia, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-0359","authenticated-orcid":false,"given":"Deivid Ramos dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia e Traumatologia, Programa de Resid\u00eancia em Ortopedia e Traumatologia, Universidade do Estado do Par\u00e1, Bel\u00e9m, PA, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1439-6064","authenticated-orcid":false,"given":"Jo\u00e3o Carlos","family":"Belloti","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia e Traumatologia, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4933-4007","authenticated-orcid":false,"given":"Vin\u00edcius Ynoe de","family":"Moraes","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia e Traumatologia, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, 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