{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:44:28Z","timestamp":1792021468023,"version":"4.4.0"},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nerolidol, a natural sesquiterpene alcohol found in essential oils, has demonstrated antioxidant, anti-inflammatory, and neuroprotective properties. However, its effects on pentylenetetrazole (PTZ)-induced seizure and associated oxidative brain damage remain unclear.<\/jats:p>\n                  <jats:p>To evaluate the anticonvulsant effects of nerolidol on PTZ-induced seizures in mice and to investigate its impact on oxidative and nitrosative stress markers in the hippocampus and cortex.<\/jats:p>\n                  <jats:p>Male mice were divided into 5 groups: control, PTZ, and PTZ pretreated with nerolidol (25, 50, or 100\u2009mg\/kg, orally) 30\u2009minutes before PTZ administration. Seizure activity was assessed by measuring latencies to minimal clonic seizures (MCSs) and generalized tonic-clonic seizures (GTCSs). After a behavioral evaluation, hippocampal and cortical tissues were analyzed for malondialdehyde (MDA), nitric oxide (NO) metabolites, superoxide dismutase (SOD), catalase (CT), and total thiol content.<\/jats:p>\n                  <jats:p>Nerolidol significantly increased MCS and GTCS latencies compared with the PTZ group. In the hippocampus, all doses reduced MDA levels, while in the cortex this effect was observed at 50 and 100\u2009mg\/kg. Nitric oxide metabolites were decreased by the two higher doses in both brain regions. The PTZ-induced reductions in SOD and CT activities were reversed by nerolidol at all doses, and total thiol levels were restored at 50 and 100\u2009mg\/kg.<\/jats:p>\n                  <jats:p>Nerolidol exhibits anticonvulsant and neuroprotective effects on PTZ-induced seizures, likely mediated by reduced oxidative and nitrosative stress and enhancement of endogenous antioxidant defenses.<\/jats:p>","DOI":"10.1055\/s-0046-1825524","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:58:40Z","timestamp":1784069920000},"page":"001-009","source":"Crossref","is-referenced-by-count":1,"title":["Effect of nerolidol on seizure and oxidative brain damage induced by pentylenetetrazole in mice"],"prefix":"10.1055","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9186-8274","authenticated-orcid":false,"given":"Seyed Hesam","family":"Hojjat","sequence":"additional","affiliation":[{"name":"School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran."},{"name":"Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1480-9372","authenticated-orcid":false,"given":"Fatemeh","family":"Rasouli","sequence":"additional","affiliation":[{"name":"School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4813-6030","authenticated-orcid":false,"given":"Farzaneh","family":"Shakeri","sequence":"additional","affiliation":[{"name":"Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran."},{"name":"Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1055\/s-0040-1718719","article-title":"Epilepsy-Definition, Classification, Pathophysiology, and Epidemiology","volume":"40","author":"J Falco-Walter","year":"2020","journal-title":"Semin Neurol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1093\/med\/9780198791577.003.0002","volume-title":"2 Antiepileptic Drugs and Behaviour: Mechanisms of Action","author":"A E Cavanna","year":"2018"},{"issue":"03","key":"ref3","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1001\/jamaneurol.2017.3949","article-title":"Treatment outcomes in patients with newly diagnosed epilepsy treated with established and new antiepileptic drugs: a 30-year longitudinal cohort study","volume":"75","author":"Z Chen","year":"2018","journal-title":"JAMA 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