{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:50:11Z","timestamp":1791366611137,"version":"4.3.1"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"07","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":61,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder characterized by spasticity, lower limb weakness, impaired balance, and increased risk of falls.<\/jats:p>\n                  <jats:p>To evaluate the effect of vestibular rehabilitation associated with virtual reality (VRi) on functional balance in patients with HSP.<\/jats:p>\n                  <jats:p>A randomized pilot clinical trial was conducted with 16 patients who were diagnosed with HSP and divided into two groups: GI (balance games) and GII (balance\u2009+\u2009strength games). Interventions were performed via the Wii console and the Wii Balance Board platform (Nintendo Co, Ltd.). The Berg balance scale (BBS) and physiological profile assessment (PPA) were administered at T0 (prerehabilitation), T1 (after 10 sessions), and T2 (after 20 sessions). The Friedman test and Wilcoxon test were used to analyze temporal changes, the Mann\u2013Whitney test was used to compare the groups.<\/jats:p>\n                  <jats:p>All patients reported imbalance and muscle fatigue, whereas heaviness in the lower limbs and weakness were more common in GII. The visual contrast domain showed a significant change from T0 to T2, with scores increasing by a median of 2.0 (18.5\u201320.5) units.<\/jats:p>\n                  <jats:p>The use of VRi showed potential as a therapeutic adjunct in HSP rehabilitation, with improvements in balance and fall risk. However, larger studies are needed to corroborate these results.<\/jats:p>\n                  <jats:p>ReBEC (RBR-3JMX67, 01\/29\/2020). https:\/\/ensaiosclinicos.gov.br\/rg\/RBR-3jmx67.<\/jats:p>","DOI":"10.1055\/s-0046-1827050","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:10:18Z","timestamp":1788217818000},"page":"001-010","source":"Crossref","is-referenced-by-count":0,"title":["Vestibular rehabilitation in hereditary spastic paraplegia: a randomized pilot study"],"prefix":"10.1055","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7374-3647","authenticated-orcid":false,"given":"Geslaine Janaina Bueno dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Interna e Ci\u00eancias da Sa\u00fade, Curitiba PR, Brazil."},{"name":"Instituto Federal do Paran\u00e1, Departamento de Reabilita\u00e7\u00e3o, Curitiba PR, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7230-7744","authenticated-orcid":false,"given":"Maria Izabel Rodrigues","family":"Severiano","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Interna e Ci\u00eancias da Sa\u00fade, Curitiba PR, Brazil."},{"name":"Instituto Federal do Paran\u00e1, Departamento de Reabilita\u00e7\u00e3o, Curitiba PR, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7972-2844","authenticated-orcid":false,"given":"Fl\u00e1vio Magno","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Universidade Tuiuti do Paran\u00e1, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade da Comunica\u00e7\u00e3o Humana, Departamento de Otoneurologia, Curitiba PR, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1325-4248","authenticated-orcid":false,"given":"Cristiano Miranda de","family":"Araujo","sequence":"additional","affiliation":[{"name":"Universidade Tuiuti do Paran\u00e1, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade da Comunica\u00e7\u00e3o Humana, Departamento de Otoneurologia, Curitiba PR, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4871-2683","authenticated-orcid":false,"given":"Bianca Simone","family":"Zeigelboim","sequence":"additional","affiliation":[{"name":"Universidade Tuiuti do Paran\u00e1, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade da Comunica\u00e7\u00e3o Humana, Departamento de Otoneurologia, Curitiba PR, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2305-1073","authenticated-orcid":false,"given":"H\u00e9lio Afonso Ghizoni","family":"Teive","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Interna e Ci\u00eancias da Sa\u00fade, Curitiba PR, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1136\/jmg.2006.046425","article-title":"Exon deletions of SPG4 are a frequent cause of hereditary spastic paraplegia","volume":"44","author":"C Depienne","year":"2007","journal-title":"J Med Genet"},{"issue":"01","key":"ref2","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13024-018-0269-1","article-title":"Clinical spectrum and genetic landscape for hereditary spastic paraplegias in China","volume":"13","author":"E L Dong","year":"2018","journal-title":"Mol 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