{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T23:15:18Z","timestamp":1788045318910,"version":"build-2784847793"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Odontogenic keratocyst (OKC) is a developmental odontogenic cyst with distinctive histopathological features and a recognized potential for recurrence. However, secondary inflammation may significantly alter or obscure its classical histopathological features, resulting in diagnostic overlap with inflammatory odontogenic cysts. A 40-year-old male patient presented with an incidentally detected, well-defined radiolucent lesion in the left posterior mandible associated with an impacted third molar. The lesion remained asymptomatic for approximately 11 years. Radiographic findings initially suggested a dentigerous cyst. Surgical management consisted of extraction of the impacted tooth followed by complete enucleation of the lesion. Histopathological examination revealed a non-keratinized stratified squamous epithelial lining with prominent inflammatory infiltrate and numerous cholesterol clefts. The cystic contents lacked typical keratinaceous material and appeared as a creamy cystic fluid. Despite the absence of classical keratinization, the diagnosis of inflammation-modified OKC was supported by preserved architectural features, including epithelial fragility and detachment, daughter (satellite) cysts or focal microcystic formations, odontogenic epithelial islands, and focal dystrophic calcification. Inflammatory modification may obscure the classical histopathological features of OKC and create significant diagnostic overlap with inflammatory odontogenic cysts. The absence or attenuation of keratinization does not exclude the diagnosis of OKC when preserved architectural clues remain identifiable within the cyst wall. Careful evaluation of preserved architectural features, combined with clinicopathologic correlation, is essential for accurate diagnosis, appropriate management, and structured long-term follow-up.<\/jats:p>","DOI":"10.1055\/s-0046-1827188","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T22:32:41Z","timestamp":1788042761000},"source":"Crossref","is-referenced-by-count":0,"title":["Inflammation-Modified Odontogenic Keratocyst Mimicking an Inflammatory Cyst: A Clinically Silent Case"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6888-0639","authenticated-orcid":false,"given":"Faisal Mehsen","family":"Alali","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Al-jokhadar","sequence":"additional","affiliation":[{"name":"Department of Oral Histology and Pathology, College of Dentistry, Arab International University, Damascus, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0927-895X","authenticated-orcid":false,"given":"Mohammad Zakaria","family":"Nassani","sequence":"additional","affiliation":[{"name":"Department of Restorative and Prosthetic Dental Sciences, College of Dentistry, Dar Al Uloom University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Al-Qudsi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Ibn Al-Nafees Hospital, Ministry of Health, Damascus, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawda Omar","family":"Alghabban","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3872-0834","authenticated-orcid":false,"given":"Rafif","family":"Alshenaiber","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahad","family":"Albader","sequence":"additional","affiliation":[{"name":"Department of Conservative Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashayer Ahmed","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Department of Conservative Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassel","family":"Tarakji","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s12105-017-0794-1","article-title":"Update from the 4th edition of the World Health Organization classification of head and neck tumours: odontogenic and maxillofacial bone tumors","volume":"11","author":"J M Wright","year":"2017","journal-title":"Head Neck Pathol"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1368-8375(01)00066-5","article-title":"The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? 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