{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:45:27Z","timestamp":1792021527033,"version":"4.4.0"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":105,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dipyrone is one of the most commonly used postoperative analgesics. However, there are only two randomized, placebo-controlled clinical trials evaluating its effect in pediatric tonsillectomies.<\/jats:p>\n                  <jats:p>To compare postoperative pain outcomes following the use of pre-incisional dipyrone or placebo in pediatric adenotonsillectomy.<\/jats:p>\n                  <jats:p>This was a randomized, double-blind, parallel, placebo-controlled clinical trial in children aged 4 to 14 years who underwent adenotonsillectomy. A total of 76 participants were randomized into the intervention\/dipyrone group (n\u2009=\u200939) and the placebo group (n\u2009=\u200937). All received either dipyrone or saline solution (placebo) at one of two time points: before the surgical incision or at the end of surgery.<\/jats:p>\n                  <jats:p>The mean age was 6.8 years and weight was 32.1\u2009kg. In the intervention group, vital signs were normal and only 7.7% experienced emesis, compared with 8.1% in the placebo group. Food intake was anticipated by 1,1\u2009hours in the dipyrone group. Pain was controlled in at least 77.6% of participants at all evaluated time points (H0, H1, H3, and H6) in both groups. At H3, pain was controlled in 54.2% of the intervention group compared with 45.8% in the placebo group. In addition, the dipyrone group demonstrated a tendency toward a lower need for opioids in H1 and H3, reducing opioid administration by 50% and 52.63%, respectively, compared with placebo.<\/jats:p>\n                  <jats:p>A trend toward pain relief, earlier diet acceptance, and a lower need for opioids was observed in the group that received preemptive dipyrone. The results did not reach statistical significance, likely due to a type II error.<\/jats:p>","DOI":"10.1055\/s-0046-1827208","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:49:22Z","timestamp":1792018162000},"page":"001-008","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Analgesic Efficacy of Preemptive Dipyrone in the Postoperative Period of Adenotonsillectomy in Children: A Randomized Clinical Trial"],"prefix":"10.1055","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9940-2215","authenticated-orcid":false,"given":"Maira I. S.","family":"Stangler","sequence":"additional","affiliation":[{"name":"Graduate Program of Pediatrics at UFCSPA, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2250-9193","authenticated-orcid":false,"given":"Jos\u00e9 F.","family":"Lubianca Neto","sequence":"additional","affiliation":[{"name":"Medical School of Federal University of Health Sciences of Porto Alegre (UFCSPA), Graduate Program of Pediatrics at UFCSPA, Pediatric Otorhinolaryngology Service at Santo Ant\u00f4nio Children's Hospital, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9083-5572","authenticated-orcid":false,"given":"Marcelo N.","family":"Lubianca","sequence":"additional","affiliation":[{"name":"Medical School of Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S1808-8694(15)31210-6","article-title":"Pre and postoperative psychological profile of children submitted to adenoidectomy and\/or tonsillectomy","volume":"71","author":"I Fukuchi","year":"2005","journal-title":"Braz J Otorhinolaryngol"},{"issue":"03","key":"ref2","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/s1808-8694(15)30565-6","article-title":"Antibiotic use in post-adenotonsillectomy morbidity: a randomized prospective study","volume":"74","author":"M M Guerra","year":"2008","journal-title":"Braz J Otorhinolaryngol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1590\/S0034-72992004000400005","article-title":"Complica\u00e7\u00f5es p\u00f3s-operat\u00f3rias em tonsilectomias. [In Portuguese]","volume":"70","author":"V Wiikmann","year":"2004","journal-title":"Braz J Otorhinolaryngol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1590\/S1806-37132010001400015","article-title":"[Obstructive sleep apnea in children]","volume":"36","author":"S C Fagondes","year":"2010","journal-title":"J Bras Pneumol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1590\/S0034-72992004000300006","article-title":"Estudo comparativo entre duas t\u00e9cnicas de tonsilectomia: bisturi harm\u00f4nico (Ultracision) e dissec\u00e7\u00e3o tradicional com bisturi de l\u00e2mina fria","volume":"70","author":"F A Ramos","year":"2004","journal-title":"Braz J Otorhinolaryngol"},{"issue":"01","key":"ref6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.bjane.2020.12.003","article-title":"Intraoperative clonidine to prevent postoperative emergence delirium following sevoflurane anesthesia in pediatric patients: a randomized clinical trial","volume":"71","author":"F A Sousa-J\u00fanior","year":"2021","journal-title":"Braz J Anesthesiol"},{"key":"ref7","volume-title":"Mastering in pain","author":"M Feurestein","year":"1979"},{"issue":"05","key":"ref8","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1097\/00000539-199905000-00013","article-title":"Distress during the induction of anesthesia and postoperative behavioral outcomes","volume":"88","author":"Z N Kain","year":"1999","journal-title":"Anesth Analg"},{"issue":"03","key":"ref9","first-page":"430","article-title":"A rela\u00e7\u00e3o intersubjetiva entre o enfermeiro e a crian\u00e7a com dor na fase p\u00f3s-operat\u00f3ria no ato de cuidar. Esc Anna Nery Rev Enferm","volume":"12","author":"K R Persegona","year":"2008"},{"issue":"01","key":"ref10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.5935\/1808-8694.20130015","article-title":"Intravenous paracetamol and dipyrone for postoperative analgesia after day-case tonsillectomy in children: a prospective, randomized, double blind, placebo controlled study","volume":"79","author":"A I Kocum","year":"2013","journal-title":"Braz J Otorhinolaryngol"},{"issue":"06","key":"ref11","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.bjane.2013.09.010","article-title":"[Administration of paracetamol versus dipyrone by intravenous patient-controlled analgesia for postoperative pain relief in children after tonsillectomy]","volume":"65","author":"M Sener","year":"2015","journal-title":"Rev Bras Anestesiol"},{"issue":"03","key":"ref12","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1590\/S1676-26492006000500006","article-title":"Language validation of two scales to evaluate sleep quality in children","volume":"12","author":"B HB Batista","year":"2006","journal-title":"J Epilepsy Clin Neurophysiol"},{"key":"ref13","volume-title":"Validation of a scale for assessing pain in Brazilian children under five years of age","author":"M MO Alves","year":"2007"},{"issue":"03","key":"ref14","doi-asserted-by":"publisher","first-page":"323","DOI":"10.4045\/tidsskr.13.1145","article-title":"[VAS\u2013visual analog scale]","volume":"134","author":"K W Faiz","year":"2014","journal-title":"Tidsskr Nor Laegeforen"},{"key":"ref15","volume-title":"Department of Health Care. 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