{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:54:19Z","timestamp":1791590059254,"version":"4.3.4"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":130,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sleep Sci"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Obstructive sleep apnea (OSA) increases cardiovascular disease risk through systemic inflammation, particularly through elevated C-reactive protein (CRP). This study investigated whether CRP stratification predicts mortality and cardiovascular events in OSA patients.<\/jats:p>\n                  <jats:p>We conducted a retrospective cohort analysis using the TriNetX Research Network, encompassing electronic health records from 130 healthcare institutions. Adults (ages 18\u201390 years) with OSA were stratified by CRP concentration: elevated (\u2265\u20093.0\u2009mg\/L) versus low (\u2264\u20092.9\u2009mg\/L). After propensity score matching for demographics and comorbidities, 240,727 participants per cohort were followed for five years. Primary outcome was all-cause mortality; secondary outcomes included cardiovascular events, arrhythmias, and acute kidney injury.<\/jats:p>\n                  <jats:p>Elevated CRP was associated with significantly higher all-cause mortality (11.3% versus 7.0%; HR 1.695, 95% CI 1.662\u20131.727; p\u2009&lt;\u20090.001). The elevated CRP group demonstrated heightened cardiovascular risk: cardiogenic shock (1.0% versus 0.5%; HR 2.003), heart failure (9.8% versus 6.5%; HR 1.594), pulmonary hypertension (4.9% versus 3.4%; HR 1.508), and acute kidney injury (11.0% versus 6.4%; HR 1.825), all p\u2009&lt;\u20090.001. Arrhythmic complications were also increased: atrial fibrillation\/flutter (6.3% versus 4.8%; HR 1.372) and ventricular tachycardia (2.3% versus 1.8%; HR 1.388), both p\u2009&lt;\u20090.001.<\/jats:p>\n                  <jats:p>Elevated CRP constitutes a robust predictor of mortality and cardiovascular morbidity in OSA populations. Assessment of inflammatory biomarkers may enhance risk stratification, informing intensified monitoring and targeted therapeutic interventions.<\/jats:p>","DOI":"10.1055\/s-0046-1829074","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:47:12Z","timestamp":1791589632000},"page":"001-009","source":"Crossref","is-referenced-by-count":0,"title":["C-Reactive Protein as a Predictor of Cardiovascular Events and Mortality in Obstructive Sleep Apnea: A Propensity-Matched Analysis Using the TriNetX Research Network"],"prefix":"10.1055","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5396-0955","authenticated-orcid":false,"given":"Ekow","family":"Essien","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Advocate Aurora Health Care, Milwaukee, Wisconsin, United 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States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3710-454X","authenticated-orcid":false,"given":"Justice","family":"Owusu-Achiaw","sequence":"additional","affiliation":[{"name":"Department of Polyclinic, 37 Military Hospital, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6412-7279","authenticated-orcid":false,"given":"Samuel B.","family":"Governor","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St. John's Episcopal Hospital, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"issue":"09","key":"ref1","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.3390\/diagnostics15091088","article-title":"The Global Burden of Obstructive Sleep Apnea","volume":"15","author":"G Iannella","year":"2025","journal-title":"Diagnostics 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