{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:54:03Z","timestamp":1791590043032,"version":"4.3.4"},"reference-count":51,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":130,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sleep Sci"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Periodontal disease (PD) and obstructive sleep apnea (OSA) are prevalent chronic inflammatory conditions affecting over 50% of Colombians and a substantial proportion of the global population. This study investigated genetic associations between interleukin (IL) gene variants (IL-1\u03b2, IL-10, IL-17) and the risk of PD, OSA, or their coexistence in 129 Colombian individuals, including cases (PD, OSA, PD\u2009+\u2009OSA) and healthy controls. Genotyping was performed using PCR amplification and Sanger sequencing. Key findings revealed that IL-1\u03b2 variants (rs1143627, rs16944) significantly increased OSA risk (OR\u2009=\u20093.6 and 3.36; p\u2009=\u20090.004 and 0.008). The IL-10 (rs1800896) also elevated OSA risk (OR\u2009=\u20094.44; p\u2009=\u20090.004), whereas the IL-17 (rs2275913) showed a protective effect (OR\u2009=\u20090.21; p\u2009=\u20090.0003). Among individuals with PD\u2009+\u2009OSA, IL-1\u03b2 variants (rs1143627, rs16944) conferred an even higher risk (OR\u2009=\u20094.8; p\u2009=\u20090.0007\u20130.0008). No significant genetic associations were found for PD alone. In conclusion, these findings highlight the central role of inflammation in PD-OSA comorbidity, driven by dysregulated interleukin signaling pathways. Variants in IL-1\u03b2 and IL-10 may predispose individuals to both conditions, suggesting shared inflammatory mechanisms. These insights could inform the development of targeted therapies addressing inflammatory pathways underlying PD and OSA. The study underscores the importance of genetic and molecular research in advancing personalized treatment strategies for overlapping chronic diseases.<\/jats:p>","DOI":"10.1055\/s-0046-1829075","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:47:12Z","timestamp":1791589632000},"page":"001-009","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Link Between Inflammatory Gene Variants and Phenotypes of Periodontal Disease and Obstructive Sleep Apnea"],"prefix":"10.1055","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3346-530X","authenticated-orcid":false,"given":"Lauren","family":"Sofia Yepes Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Biology, Sciences Faculty, Universidad Nacional de Colombia, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8304-2047","authenticated-orcid":false,"given":"Mariana","family":"Almonacid Garz\u00f3n","sequence":"additional","affiliation":[{"name":"Health Sciences Faculty, Universidad Colegio Mayor de Cundinamarca, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0006-7822","authenticated-orcid":false,"given":"Mayra","family":"Alexandra T\u00e9llez Corral","sequence":"additional","affiliation":[{"name":"Dental Center Research, Dentistry Faculty, Pontificia Universidad Javeriana, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7249-4079","authenticated-orcid":false,"given":"Francisco","family":"Sir-Mendoza","sequence":"additional","affiliation":[{"name":"Instituto de Gen\u00e9tica, Medicine Faculty, Universidad Nacional de Colombia, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1803-9141","authenticated-orcid":false,"given":"Liliana","family":"Otero","sequence":"additional","affiliation":[{"name":"Dental Center Research, Dentistry Faculty, Pontificia Universidad Javeriana, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7820-0799","authenticated-orcid":false,"given":"Mauricio","family":"Rey Buitrago","sequence":"additional","affiliation":[{"name":"Instituto de Gen\u00e9tica, Medicine Faculty, Universidad Nacional de Colombia, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","article-title":"Periodontal diseases","volume":"3","author":"D F Kinane","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1902\/jop.2015.140520","article-title":"Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 to 2012","volume":"86","author":"P I Eke","year":"2015","journal-title":"J Periodontol"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/sj.bdj.2012.1088","article-title":"Adult Dental Health Survey 2009: common oral health conditions and their impact on the population","volume":"213","author":"D A White","year":"2012","journal-title":"Br Dent J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2146160","DOI":"10.1155\/2020\/2146160","article-title":"Global Prevalence of Periodontal Disease and Lack of Its Surveillance","volume":"2020","author":"M Nazir","year":"2020","journal-title":"ScientificWorldJournal"},{"key":"ref5","author":"Rep\u00fablica de Colombia","year":"2013"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.47102\/annals-acadmedsg.V34N1p111","article-title":"Periodontal disease -- the emergence of a risk for systemic conditions: pre-term low birth weight","volume":"34","author":"B K Yeo","year":"2005","journal-title":"Ann Acad Med Singap"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"e359","DOI":"10.4317\/jced.59478","article-title":"Is periodontitis associated with obstructive sleep apnea? 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