{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T12:24:20Z","timestamp":1766579060443},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p>Autoimmune chronic lymphocytic thyroiditis appears in two forms, goitrous and atrophic. The evidence available is not enough to prove that the goitrous precedes the atrophic form, but immunogenetic analysis suggests that they may be distinct entities. The distribution of HLA class II alleles DRB1* and DQB1* was verified in patients from the region of Campinas, S\u00e3o Paulo, Brazil with both forms of thyroiditis. Ninety-one patients with primary hypothyroidism through autoimmune thyroiditis were classified as goitrous - 54 patients, 42.27 \u00b1 11.72 years old, having had hypothyroidism for 8.57 \u00b1 6.63 years - or atrophic - 37 patients, 42.72 \u00b1 12.01 years old, hypothyroidism for 6.73 \u00b1 4.07 years. The distribution of class II alleles was determined, DRB1* and DQB1* were genotyped after purifying DNA blood samples using the DNAzol technique, and the low-resolution PCR-SSP system was utilized for determination of generic alleles. Chi-square and Fisher\u2019s exact test were\n                  utilized to compare the distribution frequency of HLA alleles and the significant p-values were subjected to Bonferroni correction. We have demonstrated that the DRB1*04 allele is associated with autoimmune thyroiditis, and that there are genotypic differences regarding the presentation forms with a strong association between DRB1*04 and DQB1*03 and the atrophic form only.<\/jats:p>","DOI":"10.1055\/s-2004-825732","type":"journal-article","created":{"date-parts":[[2004,8,11]],"date-time":"2004-08-11T08:04:48Z","timestamp":1092211488000},"page":"492-500","source":"Crossref","is-referenced-by-count":14,"title":["HLA-DRB1*04 and HLA-DQB1*03 Association with the Atrophic but not with the Goitrous Form of Chronic Autoimmune Thyroiditis in a Brazilian Population"],"prefix":"10.1055","volume":"36","author":[{"given":"D.","family":"Engelbrecht Zantut-Wittmann","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, State University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Persoli","sequence":"additional","affiliation":[{"name":"Histocompatibility Laboratory-Hemocentro School of Medical Sciences, State University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Tambascia","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, State University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, State University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Franco Maldonado","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, State University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Costa","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, State University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. J.","family":"Pavin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, State University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2004,8,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1210\/jcem-61-6-1172","article-title":"A long-term clinical, immunological, and histological follow-up study of patients with goitrous chronic lymphocytic thyroiditis.","volume":"61","author":"Y Hayashi","year":"1985","journal-title":"J Clin Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM197807202990306","article-title":"Hashimoto\u2019s thyroiditis is associated with HLA-Drw3.","volume":"299","author":"H Moens","year":"1978","journal-title":"N Engl J 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